ChemicalBook > CAS DataBase List > HS-10296

HS-10296

Product Name: HS-10296
CAS No.: 1899921-05-1
Chemical Name: HS-10296
Synonyms: HS-10296;Almonertinib;D6-Almonertinib;HS 10296;HS10296;2H6]-Almonertinib;Almonertinib (HS-10296);Almonertinib, 10 mM in DMSO;HS-10296;HS 10296;HS10296;1899921-05-1;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide
CBNumber: CB14808621
Molecular Formula: C30H35N7O2
Formula Weight: 525.66
MOL File: 1899921-05-1.mol

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HS-10296 Property

Density: 1.24±0.1 g/cm3(Predicted)
solubility: DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM)
pka: 12.68±0.70(Predicted)
form: Solid
color: Off-white to light yellow
InChIKey: DOEOECWDNSEFDN-UHFFFAOYSA-N
SMILES: N(C1C=C(NC(=O)C=C)C(N(C)CCN(C)C)=CC=1OC)C1=NC=CC(C2C3=CC=CC=C3N(C3CC3)C=2)=N1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 10mg
Price: $400
Updated: 2021/12/16

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 25mg
Price: $750
Updated: 2021/12/16

ChemScene

Product number: CS-0066162
Product name: Almonertinib
Purity: 99.84%
Packaging: 50mg
Price: $1050
Updated: 2021/12/16

Biorbyt Ltd

Product number: orb573138
Product name: HS-10296
Purity: >98%
Packaging: 100mg
Price: $1283.5
Updated: 2021/12/16

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HS-10296 Chemical Properties,Usage,Production

Uses

Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.

Mechanism of action

Almonertinib inhibits EGFR tyrosine kinase targeting EGFR-sensitizing and T790M resistance mutations.

IC 50

EGFR^T790M: 0.37 nM (IC₅₀); EGFR^L858R/T790M: 0.29 nM (IC₅₀); EGFR^{del19 T790M}: 0.21 nM (IC₅₀)

HS-10296 Preparation Products And Raw materials

Raw materials

Preparation Products

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HS-10296 Suppliers

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1899921-05-1, HS-10296Related Search:

HS-10296

N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide

HS-10296;HS 10296;HS10296;1899921-05-1

HS 10296;HS10296

Almonertinib (HS-10296)

Almonertinib

2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-

N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide

2H6]-Almonertinib

inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC

Almonertinib, 10 mM in DMSO

D6-Almonertinib

1899921-05-1

C30H35N7O2