ChemicalBook > CAS DataBase List > HS-10296
HS-10296
- Product Name
- HS-10296
- CAS No.
- 1899921-05-1
- Chemical Name
- HS-10296
- Synonyms
- HS-10296;Almonertinib;HS 10296;HS10296;2H6]-Almonertinib;Almonertinib (HS-10296);HS-10296;HS 10296;HS10296;1899921-05-1;N-(5-((4-(1-cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(meth)amino)-4-methoxyphenyl)acrylamide;N-(5-((4-(1-Cyclopropyl-1H-indol-3-yl)pyrimidin-2-yl)amino)-2-((2-(dimethylamino)ethyl)(methyl)amino)-4-methoxyphenyl)acrylamide;2-Propenamide, N-[5-[[4-(1-cyclopropyl-1H-indol-3-yl)-2-pyrimidinyl]amino]-2-[[2-(dimethylamino)ethyl]methylamino]-4-methoxyphenyl]-;inhibit,non-small,L861Q,del19,HER1,HS 10296,EGFR,mutations,L858R,lung,Inhibitor,HS10296,Almonertinib,cancer,Epidermal growth factor receptor,cell,ErbB-1,G719X,antineoplastic,oral,NSCLC
- CBNumber
- CB14808621
- Molecular Formula
- C30H35N7O2
- Formula Weight
- 525.66
- MOL File
- 1899921-05-1.mol
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HS-10296 Property
- Density
- 1.24±0.1 g/cm3(Predicted)
- solubility
- DMSO:91.67(Max Conc. mg/mL);174.38(Max Conc. mM)
Ethanol:6.0(Max Conc. mg/mL);11.41(Max Conc. mM) - pka
- 12.68±0.70(Predicted)
- form
- Solid
- color
- Off-white to light yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0066162
- Product name
- Almonertinib
- Purity
- 99.84%
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0066162
- Product name
- Almonertinib
- Purity
- 99.84%
- Packaging
- 10mg
- Price
- $400
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0066162
- Product name
- Almonertinib
- Purity
- 99.84%
- Packaging
- 25mg
- Price
- $750
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0066162
- Product name
- Almonertinib
- Purity
- 99.84%
- Packaging
- 50mg
- Price
- $1050
- Updated
- 2021/12/16
Biorbyt Ltd
- Product number
- orb573138
- Product name
- HS-10296
- Purity
- >98%
- Packaging
- 100mg
- Price
- $1283.5
- Updated
- 2021/12/16
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HS-10296 Chemical Properties,Usage,Production
Uses
Almonertinib (HS-10296) is an orally available, irreversible, third-generation EGFR tyrosine kinase inhibitor with high selectivity for EGFR-sensitizing and T790M resistance mutations. Almonertinib shows great inhibitory activity against T790M, T790M/L858R and T790M/Del19 (IC50: 0.37, 0.29 and 0.21 nM, respectively), and is less effective against wild type (3.39 nM). Almonertinib is used for the research of the non-small cell lung cancer.
Mechanism of action
Almonertinib inhibits EGFR tyrosine kinase targeting EGFR-sensitizing and T790M resistance mutations.
HS-10296 Preparation Products And Raw materials
Raw materials
Preparation Products
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