Nrf2 Transcription Factor Assay Kit
- Product Name
- Nrf2 Transcription Factor Assay Kit
- Chemical Name
- Nrf2 Transcription Factor Assay Kit
- Synonyms
- Nrf2 Transcription Factor Assay Kit
- CBNumber
- CB14814974
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- 600590
- Product name
- Nrf2 Transcription Factor Assay Kit
- Packaging
- 96Well
- Price
- $493
- Updated
- 2024/03/01
Nrf2 Transcription Factor Assay Kit Chemical Properties,Usage,Production
Description
Nuclear factor E2-related factor 2 (Nrf2) is a transcription factor that plays a key role in maintaining redox homeostasis via its interaction with a cysteine-rich protein Kelch-like ECH-associated protein 1 (Keap1). In resting cells, Nrf2 and Keap1 form a tight complex, which is targeted for degradation by proteasomes. Under oxidative stress, Nrf2 is released from the Nrf2/Keap1 complex and translocates to the nucleus where it is able to induce the expression of a battery of genes encoding diverse cytoprotective proteins, including antioxidative enzymes, anti-inflammatory mediators, and proteasomes. Cayman’s Nrf2 Transcription Factor Assay is a non-radioactive, colorimetric method for detecting specific transcription factor DNA binding activity in nuclear extracts. A specific double stranded DNA (dsDNA) sequence containing the Nrf2 response element is immobilized onto the wells of a 96-well plate. Nrf2 contained in nuclear extract samples will bind specifically to the Nrf2 response element and can be detected by addition of a specific Nrf2 antibody and a secondary antibody conjugated to HRP.Needed but not supplied: Please download the kit booklet to verify if UltraPure Water (Milli-Q or equivalent) or any other components are needed for this assay.WARNING This product is not for human or veterinary use.
Nrf2 Transcription Factor Assay Kit Preparation Products And Raw materials
Raw materials
Preparation Products
Nrf2 Transcription Factor Assay Kit Suppliers
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