Borussertib

Product Name: Borussertib
CAS No.: 1800070-77-2
Chemical Name: Borussertib
Synonyms: Borussertib;Borussertib, 10 mM in DMSO;Borussertib,Inhibitor,PKB,Akt,Protein kinase B,inhibit;N-[2-oxo-3-(1-{[4-(5-oxo-3-phenyl-6H-1,6-naphthyridin-2-yl)phenyl]methyl}piperidin-4-yl)-1H-1,3-benzodiazol-5-yl]prop-2-enamide - [AC80954];2-Propenamide, N-[3-[1-[[4-(5,6-dihydro-5-oxo-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl]-
CBNumber: CB14844579
Molecular Formula: C36H32N6O3
Formula Weight: 596.68
MOL File: 1800070-77-2.mol

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Borussertib Property

Density: 1.318±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: DMSO : 25 mg/mL (41.90 mM; Need ultrasonic)
pka: 10.74±0.20(Predicted)
form: Solid
color: White to off-white

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene

Product number: CS-0090402
Product name: Borussertib
Purity: 98.59%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0090402
Product name: Borussertib
Purity: 98.59%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0090402
Product name: Borussertib
Purity: 98.59%
Packaging: 25mg
Price: $990
Updated: 2021/12/16

DC Chemicals

Product number: DC21869
Product name: Borussertib
Purity: >98%
Packaging: 250mg
Price: $1500
Updated: 2021/12/16

DC Chemicals

Product number: DC21869
Product name: Borussertib
Purity: >98%
Packaging: 1g
Price: $3000
Updated: 2021/12/16

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Borussertib Chemical Properties,Usage,Production

Uses

Borussertib is a covalent-allosteric and first-in-class inhibitor of protein kinase Akt, with an IC50 of 0.8 nM and a Ki of 2.2 nM for Aktwt[1].

References

[1] Niklas Uhlenbrock, et al. Structural and chemical insights into the covalentallosteric inhibition of the protein kinase Akt. Chem Sci., 2019, 10, 3573.

Borussertib Preparation Products And Raw materials

Raw materials

Preparation Products

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Borussertib Suppliers

China 35 United States 4 Global 39

BOC Sciences

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1800070-77-2, BorussertibRelated Search:

Borussertib

2-Propenamide, N-[3-[1-[[4-(5,6-dihydro-5-oxo-3-phenyl-1,6-naphthyridin-2-yl)phenyl]methyl]-4-piperidinyl]-2,3-dihydro-2-oxo-1H-benzimidazol-5-yl]-

Borussertib,Inhibitor,PKB,Akt,Protein kinase B,inhibit

Borussertib, 10 mM in DMSO

N-[2-oxo-3-(1-{[4-(5-oxo-3-phenyl-6H-1,6-naphthyridin-2-yl)phenyl]methyl}piperidin-4-yl)-1H-1,3-benzodiazol-5-yl]prop-2-enamide - [AC80954]

1800070-77-2