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RG7834 (Synonyms: RO 7020322)

Product Name
RG7834 (Synonyms: RO 7020322)
CAS No.
2072057-17-9
Chemical Name
RG7834 (Synonyms: RO 7020322)
Synonyms
RG7834 S-isomer;RG7834 (RO 7020322);RG78349（RO 7020322）;RG7834, 10 mM in DMSO;RG7834 (Synonyms: RO 7020322);Hepatitis B virus,RG 7834,RG-7834,RO-7020322,RG7834,inhibit,Inhibitor,RO7020322,HBV;(6S)-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6-(propan-2-yl)-2H,6H,7H-pyrido[2,1-a]isoquinoline-3-carboxylic acid;2H-Benzo[a]quinolizine-3-carboxylic acid, 6,7-dihydro-10-methoxy-9-(3-methoxypropoxy)-6-(1-methylethyl)-2-oxo-, (6S)-
CBNumber
CB14845051
Molecular Formula
C22H27NO6
Formula Weight
401.45
MOL File
2072057-17-9.mol
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RG7834 (Synonyms: RO 7020322) Property

Boiling point:
578.6±50.0 °C(Predicted)
Density 
1.27±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO:100.0(Max Conc. mg/mL);249.1(Max Conc. mM)
form 
Solid
pka
5.91±0.40(Predicted)
color 
Light yellow to yellow
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0084529
Product name
RG7834
Purity
99.29%
Packaging
5mg
Price
$90
Updated
2021/12/16
ChemScene
Product number
CS-0084529
Product name
RG7834
Purity
99.29%
Packaging
10mg
Price
$160
Updated
2021/12/16
ChemScene
Product number
CS-0084529
Product name
RG7834
Purity
99.29%
Packaging
50mg
Price
$630
Updated
2021/12/16
ChemScene
Product number
CS-0084529
Product name
RG7834
Purity
99.29%
Packaging
100mg
Price
$1050
Updated
2021/12/16
DC Chemicals
Product number
DC20005
Product name
RG7834(RO7020322)
Purity
>98%
Packaging
250mg
Price
$1200
Updated
2021/12/16
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RG7834 (Synonyms: RO 7020322) Chemical Properties,Usage,Production

Uses

RG7834 (RO 7020322) is a highly selective and orally bioavailable HBV inhibitor, potently inhibits HBV antigens (both HBsAg and HBeAg) and HBV DNA, with IC50s of 2.8, 2.6, and 3.2 nM, respectively, in dHepaRG Cells[1].

in vivo

RG7834 (4 mg/kg, twice daily for 21 days) shows anti-HBV efficacy in HBV-infected human liver chimeric uPA-SCID mice[1].
RG7834 (2, 14.5 mg/kg, p.o.) exhibits good oral bioavail ability, with a half-life of 4.9 h in mice[1].

Animal Model:HBV-infected human liver chimeric uPA-SCID mice[1]
Dosage:4 mg/kg
Administration:Twice daily for 21 days
Result:Reduced both HBsAg and HBeAg, also decreased serum HBV DNA by 0.6 log10 in mice.

References

[1] Han X, et al. Discovery of RG7834: The First-in-Class Selective and Orally Available Small Molecule Hepatitis B Virus Expression Inhibitor with Novel Mechanism of Action. J Med Chem. 2018 Oct 4. DOI:10.1021/acs.jmedchem.8b01245

RG7834 (Synonyms: RO 7020322) Preparation Products And Raw materials

Raw materials

Preparation Products

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RG7834 (Synonyms: RO 7020322) Suppliers

China 45 United States 4 Global 49
TargetMol Chemicals Inc.
Tel
+1-781-999-5354; +17819995354
Email
marketing@targetmol.com
Country
United States
ProdList
32435
Advantage
58
InvivoChem
Tel
+1-708-310-1919 +1-13798911105
Fax
708-557-7486
Email
sales@invivochem.cn
Country
United States
ProdList
6391
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354;
Email
support@targetmol.com
Country
United States
ProdList
39035
Advantage
58
Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52923
Advantage
58

2072057-17-9, RG7834 (Synonyms: RO 7020322)Related Search:


  • RG7834 (Synonyms: RO 7020322)
  • RG7834 (RO 7020322)
  • 2H-Benzo[a]quinolizine-3-carboxylic acid, 6,7-dihydro-10-methoxy-9-(3-methoxypropoxy)-6-(1-methylethyl)-2-oxo-, (6S)-
  • RG7834 S-isomer
  • RG78349（RO 7020322）
  • Hepatitis B virus,RG 7834,RG-7834,RO-7020322,RG7834,inhibit,Inhibitor,RO7020322,HBV
  • (6S)-10-methoxy-9-(3-methoxypropoxy)-2-oxo-6-(propan-2-yl)-2H,6H,7H-pyrido[2,1-a]isoquinoline-3-carboxylic acid
  • RG7834, 10 mM in DMSO
  • 2072057-17-9