4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
- Product Name
- 4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
- CAS No.
- 5122-36-1
- Chemical Name
- 4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
- Synonyms
- FAPy-adenine;DIAMINO-15N2);DIAMINO-15N2, 98%);Adenosine Impurity 33;FAPYADENINE(FORMYL-13C;4,6-diamino-5-n-formamidopyrimidine;4,6-DIAMONO-5-(FORMYLAMINO)PYRIMIDNE;4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE;N-(4,6-Diaminopyrimidin-5-yl)formamide;4,6 diamino-5-formamide pyrimidine HCl
- CBNumber
- CB1484939
- Molecular Formula
- C5H7N5O
- Formula Weight
- 153.14
- MOL File
- 5122-36-1.mol
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE Property
- Melting point:
- 224-226 °C
- Boiling point:
- 536.1±50.0 °C(Predicted)
- Density
- 1.575±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- pka
- 12.35±0.70(Predicted)
- form
- Solid
- color
- Off-white to light yellow
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- CS-0059551
- Product name
- FAPy-adenine
- Purity
- 99.93%
- Packaging
- 10mg
- Price
- $100
- Updated
- 2021/12/16
- Product number
- CS-0059551
- Product name
- FAPy-adenine
- Purity
- 99.93%
- Packaging
- 25mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- CS-0059551
- Product name
- FAPy-adenine
- Purity
- 99.93%
- Packaging
- 50mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- CS-0059551
- Product name
- FAPy-adenine
- Purity
- 99.93%
- Packaging
- 100mg
- Price
- $420
- Updated
- 2021/12/16
- Product number
- CHM0310353
- Product name
- 4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $501.22
- Updated
- 2021/12/16
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE Chemical Properties,Usage,Production
Uses
FAPy-adenine is an oxidized DNA base. Fapy-adenine shows an increased trend levels in the Alzheimer's disease brain. Oxidized nucleosides are biochemical markers for tumors, aging, and neurodegenerative diseases[1][2][3].
Definition
ChEBI: A member of the class of aminopyrimidines that is 4,6-diaminopyrimidine bearing an additional formamido substituent at position 5. A DNA lesion formed when DNA exposed to ionising radiation.
in vivo
The nuclear DNA damage by oxygen-derived radicals is increased in Alzheimer's disease and support the concept that the brain is under increased oxidative stress in Alzheimer's disease[1].
IC 50
Human Endogenous Metabolite
References
[1] Gabbita SP, et al. Increased nuclear DNA oxidation in the brain in Alzheimer's disease. DOI:10.1046/j.1471-4159.1998.71052034.x
[2] Cysewski P, et al. Theoretical description of the coding potential of diamino-5-formamidopyrimidines. Z Naturforsch C J Biosci. 1999 Mar-Apr;54(3-4):239-45. DOI:10.1515/znc-1999-3-414
[3] Lee SH, et al. A rapid and sensitive method for quantitation of nucleosides in human urine using liquid chromatography/mass spectrometry with direct urine injection. Rapid Commun Mass Spectrom. 2004;18(9):973-7. DOI:10.1046/j.1471-4159.1998.71052034.x
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE Preparation Products And Raw materials
Raw materials
Preparation Products
4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE Suppliers
- Tel
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- sales@carbosynth.com
- Country
- United Kingdom
- ProdList
- 6005
- Advantage
- 58
- Tel
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- sales@carbonesci.com
- Country
- United Kingdom
- ProdList
- 6666
- Advantage
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View Lastest Price from 4,6-DIAMINO-5-(FORMYLAMINO)-PYRIMIDINE manufacturers
- Product
- FAPy-adenine 5122-36-1
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- 1ton
- Release date
- 2020-01-10