CEVIMELINE, HYDROCHLORIDE SALT

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CEVIMELINE, HYDROCHLORIDE SALT

Product Name: CEVIMELINE, HYDROCHLORIDE SALT
CAS No.: 107233-08-9
Chemical Name: CEVIMELINE, HYDROCHLORIDE SALT
Synonyms: Evoxac;AF-102B;SNI-2011;3R)-rel-;Hsdb 7286;Cevimeline;3]oxathiolane];AF-102B;FKS-508;CevimelineHClSalt;CeviMeline(Evoxac)
CBNumber: CB1490161
Molecular Formula: C10H17NOS
Formula Weight: 199.31
MOL File: 107233-08-9.mol

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CEVIMELINE, HYDROCHLORIDE SALT Property

Melting point:: 195-197°C
Boiling point:: 308.5±42.0 °C(Predicted)
Density: 1.19
storage temp.: Sealed in dry,Store in freezer, under -20°C
solubility: Soluble in DMSO
form: Powder
pka: 9.51±0.40(Predicted)
CAS DataBase Reference: 107233-08-9

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Safety

Hazardous Substances Data: 107233-08-9(Hazardous Substances Data)

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biosynth Carbosynth

Product number: FC146883
Product name: Cevimeline, hydrochloridesalt
Packaging: 1mg
Price: $60
Updated: 2021/12/16

ApexBio Technology

Product number: A3299
Product name: Cevimeline
Packaging: 5mg
Price: $156
Updated: 2021/12/16

AK Scientific

Product number: X7254
Product name: Cevimeline
Packaging: 2mg
Price: $190
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FC146883
Product name: Cevimeline, hydrochloridesalt
Packaging: 5mg
Price: $207
Updated: 2021/12/16

ApexBio Technology

Product number: A3299
Product name: Cevimeline
Packaging: 10mg
Price: $229
Updated: 2021/12/16

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CEVIMELINE, HYDROCHLORIDE SALT Chemical Properties,Usage,Production

Chemical Properties

Off-White Solid

Uses

A muscarinic M1 and M3 receptor agonist. Sialagogue

Biological Activity

cevimeline is a muscarinic receptor agonist especially on the m1 and m3 receptors. [1]cevimeline has been approved for use against symptoms of dry mouth by activating the m3 receptors of the parasympathetic nervous system. cevimeline is effective and safe in improving symptoms of dry eye with 20 mg three times per day [2]. cevimeline increased the intracellular ca+ level in parotid gland acinar cells over 1 μm and rat, enhanced the excitability via muscarinic receptors, thereby, cevimeline alleviates dry mouth symptoms by stimulating secretion by the salivary glands. cevimeline has a longer duration of salivation[3]. cevimeline plays a part in alzheimer’s disease. cevimeline decreased aβ (1–40) level in the cerebrospinal fluid (csf) at 1 mg/kg without changing α-apps in rabbit and significantly decreased csf aβ in ad patients.[4]

References

1. f. b. vivino, i. al-hashimi, z. khan, f. g. leveque, p. l. salisbury, 3rd, t. k. tran-johnson, c. c. muscoplat, m. trivedi, b. goldlust and s. c. gallagher, arch intern med 1999, 159, 174-181. 2. m. ono, e. takamura, k. shinozaki, t. tsumura, t. hamano, y. yagi and k. tsubota, am j ophthalmol 2004, 138, 6-17. 3. k. ono, t. inagaki, t. iida, r. hosokawa and k. inenaga, j med invest 2009, 56 suppl, 375. 4. a. fisher, z. pittel, r. haring, n. bar-ner, m. kliger-spatz, n. natan, i. egozi, h. sonego, i. marcovitch and r. brandeis, j mol neurosci 2003, 20, 349-356.

CEVIMELINE, HYDROCHLORIDE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from CEVIMELINE, HYDROCHLORIDE SALT manufacturers

Hebei Mojin Biotechnology Co., Ltd

Product: CEVIMELINE, HYDROCHLORIDE SALT 107233-08-9
Price: US $0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 50000KG/month
Release date: 2023-08-28

Hebei Guanlang Biotechnology Co., Ltd.

Product: CEVIMELINE, HYDROCHLORIDE SALT 107233-08-9
Price: US $9.90/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2021-09-28

Career Henan Chemical Co

Product: CEVIMELINE, HYDROCHLORIDE SALT 107233-08-9
Price: US $15.00/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 1000kg
Release date: 2018-07-26

107233-08-9, CEVIMELINE, HYDROCHLORIDE SALTRelated Search:

Donepezil Gefarnate Succimer Tetrabenazine Formoterol PILOCARPINE Emtricitabine Entacapone Tacrolimus Memantine Citalopram CEVIMELINE, HYDROCHLORIDE SALT 3-Quinuclidinol hydrochloride (R)-(-)-3-Quinuclidinol 2-(4-PIPERIDYL)-2-PROPANOL 1-Azabicyclo[2.2.2]octan-3-ol,3-(mercaptomethyl)- cevimeline

CevimelineHClSalt

(+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3quinuclidine

Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, (2'R,3R)-rel-

Spiro[1-azabicyclo[2.2.2]octane-3,5'-[1,3]oxathiolane], 2'-methyl-, cis-

2-methyspiro(1,3-oxathiolane-5,3)quinuclidine

AF-102B

Evoxac

SNI-2011

Cevimeline

(+/-)-cis-2-Methylspiro[1,3-oxathiolane-5,3'-quinuclidine]

Hsdb 7286

3]oxathiolane]

3R)-rel-

2-Methyspiro(1,3-oxathiol

CeviMeline(Evoxac)

AF-102B;FKS-508

rac,cis-Cevimeline

cis-2-Methyl-1'-azaspiro[[1,3]oxathiolane-5,3'-bicyclo[2.2.2]octane

107233-08-9

C10H18ClNOS

C10H17NOSHCl

Heterocycles

Intermediates & Fine Chemicals

Neurochemicals

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