4-Chloro-3-fluorophenol
- Product Name
- 4-Chloro-3-fluorophenol
- CAS No.
- 348-60-7
- Chemical Name
- 4-Chloro-3-fluorophenol
- Synonyms
- 4-CHLORO-3-FLUOROPHENOL;3-fluoro-4-chlorophenol;Phenol, 4-chloro-3-fluoro-;4-Chloro-3-fluorophenol 98%;4-Chloro-3-fluorophenol,98%;4-Chloro-3-fluorophenol >4-Chloro-3-fluorophenol ISO 9001：2015 REACH
- CBNumber
- CB1491234
- Molecular Formula
- C6H4ClFO
- Formula Weight
- 146.55
- MOL File
- 348-60-7.mol
4-Chloro-3-fluorophenol Property
- Melting point:
- 54-56 °C (lit.)
- Boiling point:
- 84 °C/44 mmHg (lit.)
- Density
- 1.3675 (estimate)
- Flash point:
- >230 °F
- storage temp.
- Inert atmosphere,Room Temperature
- solubility
- chloroform: soluble50mg/mL, clear, colorless
- pka
- 8.52±0.18(Predicted)
- form
- Liquid
- color
- Colorless to pale yellow, may discolor to orange during storage
- BRN
- 3236440
- InChI
- InChI=1S/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H
- InChIKey
- XLHYAEBESNFTCA-UHFFFAOYSA-N
- SMILES
- C1(O)=CC=C(Cl)C(F)=C1
- CAS DataBase Reference
- 348-60-7(CAS DataBase Reference)
Safety
- Hazard Codes
- Xi,Xn
- Risk Statements
- 36/37/38-20/21/22
- Safety Statements
- 26-37/39-36/37/39-24/25
- RIDADR
- 2811
- WGK Germany
- 3
- Hazard Note
- Irritant
- HazardClass
- IRRITANT, IRRITANT-HARMFUL
- HazardClass
- 8
- HS Code
- 29081990
- Storage Class
- 11 - Combustible Solids
- Hazard Classifications
- Eye Irrit. 2
Skin Irrit. 2
STOT SE 3
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 306622
- Product name
- 4-Chloro-3-fluorophenol
- Purity
- 98%
- Packaging
- 5g
- Price
- $49.4
- Updated
- 2025/07/31
- Product number
- C2476
- Product name
- 4-Chloro-3-fluorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 5g
- Price
- $83
- Updated
- 2025/07/31
- Product number
- C2476
- Product name
- 4-Chloro-3-fluorophenol
- Purity
- >98.0%(GC)(T)
- Packaging
- 25g
- Price
- $342
- Updated
- 2025/07/31
- Product number
- C585125
- Product name
- 4-Chloro-3-fluorophenol
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- 004459
- Product name
- 4-Chloro-3-fluorophenol
- Purity
- 98%
- Packaging
- 25g
- Price
- $70
- Updated
- 2021/12/16
4-Chloro-3-fluorophenol Chemical Properties,Usage,Production
Chemical Properties
White to salmon crystalline solid
Uses
4-Chloro-3-fluorophenol was used in the synthesis of 4-chloro-3-fluoro catechol and 5-Chloro-4-fluoro-2-hydroxyacetophenone.
General Description
4-Chloro-3-fluorophenol is hydroxylated at both ortho positions to yield different products.
Synthesis
1338215-43-2
348-60-7
GENERAL METHOD: [2-(Phenoxy)-ethyl]-trimethyl-silane (195 mg, 1.0 mmol) was dissolved in anhydrous DMF (2 mL), cesium fluoride (576 mg, 3.0 mmol) was added, and the reaction was stirred for 1 hr at 60 °C. After the reaction was completed, the reaction mixture was diluted with water and extracted with ethyl acetate (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 92 mg of 4-chloro-3-fluorophenol in 93% yield. The 1H NMR data of the compound was consistent with the standard, confirming its structure.
References
[1] ISHIKAWA Y. 6-Chloro-7-fluoro-4-oxo-4H-chromene-3-carbaldehyde.[J]. Acta crystallographica. Section E, Structure reports online, 2014, 70 Pt 7: o825. DOI:10.1107/S1600536814014706.
[2] VIDYA S. SHIVATARE W. T. Vibronic and cation spectroscopy of selected rotamers of 4-chloro-3-fluorophenol[J]. Molecular Physics, 2014, 112 1: 2397-2406. DOI:10.1080/00268976.2014.904050.
4-Chloro-3-fluorophenol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 4-Chloro-3-fluorophenol manufacturers
- Product
- 4-Chloro-3-fluorophenol 348-60-7
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20 mt
- Release date
- 2024-12-03
- Product
- 4-Chloro-3-fluorophenol 348-60-7
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- Customized
- Release date
- 2019-06-27