4-Chloro-3-fluorophenol

Product Name: 4-Chloro-3-fluorophenol
CAS No.: 348-60-7
Chemical Name: 4-Chloro-3-fluorophenol
Synonyms: 4-CHLORO-3-FLUOROPHENOL;3-fluoro-4-chlorophenol;Phenol, 4-chloro-3-fluoro-;4-Chloro-3-fluorophenol 98%;4-Chloro-3-fluorophenol,98%;4-Chloro-3-fluorophenol >4-Chloro-3-fluorophenol ISO 9001：2015 REACH
CBNumber: CB1491234
Molecular Formula: C6H4ClFO
Formula Weight: 146.55
MOL File: 348-60-7.mol

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4-Chloro-3-fluorophenol Property

Melting point:: 54-56 °C (lit.)
Boiling point:: 84 °C/44 mmHg (lit.)
Density: 1.3675 (estimate)
Flash point:: >230 °F
storage temp.: Inert atmosphere,Room Temperature
solubility: chloroform: soluble50mg/mL, clear, colorless
pka: 8.52±0.18(Predicted)
form: Liquid
color: Colorless to pale yellow, may discolor to orange during storage
BRN: 3236440
InChI: InChI=1S/C6H4ClFO/c7-5-2-1-4(9)3-6(5)8/h1-3,9H
InChIKey: XLHYAEBESNFTCA-UHFFFAOYSA-N
SMILES: C1(O)=CC=C(Cl)C(F)=C1
CAS DataBase Reference: 348-60-7(CAS DataBase Reference)

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Safety

Hazard Codes: Xi,Xn
Risk Statements: 36/37/38-20/21/22
Safety Statements: 26-37/39-36/37/39-24/25
RIDADR: 2811
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, IRRITANT-HARMFUL
HazardClass: 8
HS Code: 29081990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 306622
Product name: 4-Chloro-3-fluorophenol
Purity: 98%
Packaging: 5g
Price: $49.4
Updated: 2025/07/31

TCI Chemical

Product number: C2476
Product name: 4-Chloro-3-fluorophenol
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $83
Updated: 2025/07/31

TCI Chemical

Product number: C2476
Product name: 4-Chloro-3-fluorophenol
Purity: >98.0%(GC)(T)
Packaging: 25g
Price: $342
Updated: 2025/07/31

TRC

Product number: C585125
Product name: 4-Chloro-3-fluorophenol
Packaging: 500mg
Price: $65
Updated: 2021/12/16

Oakwood

Product number: 004459
Product name: 4-Chloro-3-fluorophenol
Purity: 98%
Packaging: 25g
Price: $70
Updated: 2021/12/16

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4-Chloro-3-fluorophenol Chemical Properties,Usage,Production

Chemical Properties

White to salmon crystalline solid

Uses

4-Chloro-3-fluorophenol was used in the synthesis of 4-chloro-3-fluoro catechol and 5-Chloro-4-fluoro-2-hydroxyacetophenone.

General Description

4-Chloro-3-fluorophenol is hydroxylated at both ortho positions to yield different products.

Synthesis

1338215-43-2

348-60-7

GENERAL METHOD: [2-(Phenoxy)-ethyl]-trimethyl-silane (195 mg, 1.0 mmol) was dissolved in anhydrous DMF (2 mL), cesium fluoride (576 mg, 3.0 mmol) was added, and the reaction was stirred for 1 hr at 60 °C. After the reaction was completed, the reaction mixture was diluted with water and extracted with ethyl acetate (3 × 20 mL). The organic layers were combined, washed sequentially with water and saturated saline, dried over anhydrous sodium sulfate, and concentrated under reduced pressure to afford 92 mg of 4-chloro-3-fluorophenol in 93% yield. The 1H NMR data of the compound was consistent with the standard, confirming its structure.

References

[1] ISHIKAWA Y. 6-Chloro-7-fluoro-4-oxo-4H-chromene-3-carbaldehyde.[J]. Acta crystallographica. Section E, Structure reports online, 2014, 70 Pt 7: o825. DOI:10.1107/S1600536814014706.
[2] VIDYA S. SHIVATARE W. T. Vibronic and cation spectroscopy of selected rotamers of 4-chloro-3-fluorophenol[J]. Molecular Physics, 2014, 112 1: 2397-2406. DOI:10.1080/00268976.2014.904050.

4-Chloro-3-fluorophenol Preparation Products And Raw materials

Raw materials

Preparation Products

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4-Chloro-3-fluorophenol Suppliers

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View Lastest Price from 4-Chloro-3-fluorophenol manufacturers

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-Chloro-3-fluorophenol 348-60-7
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 20 mt
Release date: 2024-12-03

Career Henan Chemical Co

Product: 4-Chloro-3-fluorophenol 348-60-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-06-27

348-60-7, 4-Chloro-3-fluorophenolRelated Search:

3-Chlorophenol 4-Chlorophenol Cyhalothrin 4-Fluorophenol λ-Cyhalothrin Difluorochloromethane 4-CHLORO-3-FLUOROANISOLE 2-CHLORO-6-FLUOROPHENOL,2-Chloro-6-fluorophenol, 97+% 2-BROMO-4-CHLORO-6-FLUOROPHENOL 2-CHLORO-3-FLUOROPHENOL 2-BROMO-6-CHLORO-4-FLUOROPHENOL 3-CHLORO-5-FLUOROPHENOL,3-Chloro-5-fluorophenol 98%,3-Chloro-5-fluorophenol98% Phenol, 4-amino-2-chloro-3-fluoro- 2-CHLORO-4-FLUOROPHENOL,2-Chloro-4-fluorophenol, 98+%,2-Chloro-4-fluorophenol99%,2-Chloro-4-fluorophenol 99% 2,3-DICHLORO-6-FLUOROPHENOL 2,6-DICHLORO-4-FLUOROPHENOL 3-Chloro-4-fluorophenol98%,3-Chloro-4-fluorophenol 98%,3-CHLORO-4-FLUOROPHENOL 3-CHLORO-2-FLUOROPHENOL

4-Chloro-3-fluorophenol,98%

4-Chloro-3-fluorophenol 98%

3-fluoro-4-chlorophenol

4-CHLORO-3-FLUOROPHENOL

4-Chloro-3-fluorophenol &gt

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4-Chloro-3-fluorophenol ISO 9001：2015 REACH

348-60-7

384-60-7

Building Blocks

Oxygen Compounds

Phenols

Organic Building Blocks

Fluorine series

Phenol&Thiophenol&Mercaptan

Chlorine Compounds

Fluorine Compounds

Phenols

Organic Building Blocks

Oxygen Compounds

Aromatic Phenols