ChemicalBook > CAS DataBase List > 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one

Product Name
3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
CAS No.
7416-34-4
Chemical Name
3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
Synonyms
C07230;EN-1733A;MOLINDONE;EOS-60951;Molintone;Molindonum;indol-4(5h)-one;MOLINDONE USP/EP/BP;3-Ethyl-2-Methyl-5-(Morpholin-4-ylMethyl)-1,5,6,7-;3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
CBNumber
CB1497074
Molecular Formula
C16H24N2O2
Formula Weight
276.37
MOL File
7416-34-4.mol
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3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Property

Melting point:
180-181°
Boiling point:
462.9±45.0 °C(Predicted)
Density 
1.140±0.06 g/cm3(Predicted)
solubility 
H2O: 19 mg/mL
form 
solid
pka
pKa 6.9(H2O,t =25,I=0.2) (Uncertain)
color 
off-white
CAS DataBase Reference
7416-34-4(CAS DataBase Reference)
NIST Chemistry Reference
Indol-4(5h)-one, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-(7416-34-4)
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Safety

Hazard Codes 
Xn
Risk Statements 
22
RIDADR 
UN 2811 6.1/PG 3
WGK Germany 
3
RTECS 
NM3325000
Hazardous Substances Data
7416-34-4(Hazardous Substances Data)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

American Custom Chemicals Corporation
Product number
API0004720
Product name
MOLINDONE
Purity
95.00%
Packaging
1G
Price
$353.85
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
API0004720
Product name
MOLINDONE
Purity
95.00%
Packaging
2.5G
Price
$1227.82
Updated
2021/12/16
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3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Chemical Properties,Usage,Production

Originator

Moban,Endo,US,1974

Uses

Molindone is a more active antipsychotic than chloropromzine. Its sedative effect is less expressed. Side effects are also expressed less than with powerful neuroleptics. It facilitates the reduction of spontaneous movements and aggressiveness, and is used for treatment of psychotic disturbances, particularly in cases of chronic and severe schizophrenia.

Uses

Antipsychotic.

Definition

ChEBI: Molindone is a member of indoles.

Manufacturing Process

Diethyl ketone may be reacted with methyl nitrite and that product in turn reacted with cyclohexan-1,3-dione to give 3-ethyl-4,5,6,7-tetrahydro-2- methyl-4-oxoindole.
3-ethyl-4,5,6,7-tetrahydro-2-methyl-4-oxoindole 14.1 g (0.08 mol), 14.8 g morpholine hydrochloride (0.12 mol), and 3.6 g paraformaldehyde (0.12 mol) were refluxed in 200 ml ethanol for 40 hours. The solution was evaporated to dryness in vacuo on a steam bath and the residue digested with a mixture of 150 ml water and 10 ml 2N HCl. An insoluble residue of unreacted starting material was filtered off. To the acid solution, ammonia water was added dropwise with stirring and the amine crystallized out. It was purified by dissolving in 1N HCl and addition of ammonia, then by 2 crystallizations from benzene followed by 2 crystallizations from isopropanol, to yield 3-ethyl- 4,5,6,7-tetrahydro-2-methyl-4-oxoindole, melting point 180°C to 181°C.

brand name

Moban (Endo).

Therapeutic Function

Antipsychotic

Side effects

Molindone hydrochloride, a tetrahydro-indolone derivative, is a neuroleptic agent that is structurally unrelated to any of the other marketed neuroleptics. Molindone is less potent than haloperidol at blocking D2 receptors; however, it nonetheless can produce extrapyramidal side effects.

Synthesis

Molindone, 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)- one (6.4.3), is synthesized by the nitrozation of diethylketone using nitric acid or methylnitrite into nitrozodiethylketone (6.4.1). Reduction of this product with zinc in acetic acid into 2-aminodiethylketone in the presence of cyclohexandion-1,3 gives 3-ethyl-2-methyl- 4,5,6,7-tetrahydroindol-4-one (6.4.2). Aminomethylation of this product using morpholine and formaldehyde gives molindone (6.4.3) [51¨C52].

Metabolism

Metabolism studies in humans show molindone to be rapidly absorbed and metabolized when given orally. There are 36 recognized metabolites, with less than 2 to 3% unmetabolized molindone being excreted in urine and feces. Clinical studies show that the antipsychotic effects of molindone last more than 24 hours, suggesting that one or more metabolites may contribute to its activity in vivo (62).

3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Preparation Products And Raw materials

Raw materials

Preparation Products

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3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one Suppliers

XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8836
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52
HBCChem, Inc.
Tel
+1-510-219-6317
Fax
+1-650-486-1361
Email
sales@hbcchem.com
Country
United States
ProdList
10648
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60
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10274
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Jinan elephant international trading co., LTD
Tel
Fax
-
Email
13006575422@163.com
Country
China
ProdList
6355
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58
Capot Chemical Co.,Ltd.
Tel
+86-(0)57185586718 +86-13336195806
Fax
+86-571-85864795
Email
sales@capot.com
Country
China
ProdList
29791
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60
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32161
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58
CONIER CHEM AND PHARMA LIMITED
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+8618523575427
Email
sales@conier.com
Country
China
ProdList
49374
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58
career henan chemical co
Tel
+86-0371-86658258 +8613203830695
Fax
0086-371-86658258
Email
factory@coreychem.com
Country
China
ProdList
29811
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Shangqiu Ladybug Network Technology Co., LTD
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17550092151
Fax
03702782809
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3628320093@qq.com
Country
China
ProdList
4206
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58
TargetMol Chemicals Inc.
Tel
4008200310
Email
marketing@tsbiochem.com
Country
China
ProdList
24644
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58
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View Lastest Price from 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one manufacturers

Career Henan Chemical Co
Product
3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one 7416-34-4
Price
US $1.00/KG
Min. Order
1KG
Purity
85.0-99.8%
Supply Ability
20 tons
Release date
2019-12-24

7416-34-4, 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-oneRelated Search:


  • MOLINDONE
  • 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4h-indol-4-on
  • 3-ethyl-1,5,6,7-tetrahydro-2-methyl-5-(4-morpholinylmethyl)-4h-indol-4-one
  • 3-Ethyl-2-methyl-6-(4-morpholinylmethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
  • 3-ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)-indol-4(5h)-on
  • 3-Ethyl-6,7-dihydro-2-methyl-5-(morpholinomethyl)indol-4(5H)-one
  • EN-1733A
  • indol-4(5h)-one
  • C07230
  • 3-Ethyl-2-Methyl-5-(Morpholin-4-ylMethyl)-1,5,6,7-
  • 4H-Indol-4-one, 3-ethyl-1,5,6,7-tetrahydro-2-Methyl-5-(4-MorpholinylMethyl)-
  • 3-ethyl-2-methyl-5-(morpholinomethyl)-1,5,6,7-tetrahydro-4H-indol-4-one
  • EOS-60951
  • 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one
  • MOLINDONE USP/EP/BP
  • 3-Ethyl-2-methyl-5-(morpholin-4-ylmethyl)-1,5,6,7-tetrahydroindol-4-one USP/EP/BP
  • Molindonum
  • Molintone
  • 7416-34-4