1-(CYCLOPROPYLMETHYL)PIPERAZINE
- Product Name
- 1-(CYCLOPROPYLMETHYL)PIPERAZINE
- CAS No.
- 57184-25-5
- Chemical Name
- 1-(CYCLOPROPYLMETHYL)PIPERAZINE
- Synonyms
- Cyclopropylmethyl-piperazin-1-;N-(Cyclopropylmethyl)piperazine;1-(CYCLOPROPYLMETHYL)PIPERAZINE;Piperazine, 1-(cyclopropylmethyl)-;1-(CYCLOPROPYLMETHYL)PIPERAZINE 97;[(Piperazin-1-yl)methyl]cyclopropane;1-(Cyclopropylmethyl)piperazine - [C13216];1-(cyclopropylmethyl)piperazine(SALTDATA: FREE);1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 ISO 9001：2015 REACH;1-(Cyclopropylmethyl)piperazine, 97% colorless to yellow liquid
- CBNumber
- CB1500178
- Molecular Formula
- C8H16N2
- Formula Weight
- 140.23
- MOL File
- 57184-25-5.mol
1-(CYCLOPROPYLMETHYL)PIPERAZINE Property
- Boiling point:
- 68 °C/3.5 mmHg
- Density
- 0.943 g/mL at 25 °C
- refractive index
- n20/D 1.489
- Flash point:
- 171 °F
- storage temp.
- 2-8°C
- pka
- 9.25±0.10(Predicted)
- form
- liquid
- color
- Light brown
- InChI
- InChI=1S/C8H16N2/c1-2-8(1)7-10-5-3-9-4-6-10/h8-9H,1-7H2
- InChIKey
- IVLIBVDZIYFXBZ-UHFFFAOYSA-N
- SMILES
- N1(CC2CC2)CCNCC1
- CAS DataBase Reference
- 57184-25-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H227Combustible liquid
H315Causes skin irritation
H318Causes serious eye damage
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- 658839
- Product name
- 1-(Cyclopropylmethyl)piperazine
- Purity
- 97%
- Packaging
- 1g
- Price
- $67.4
- Updated
- 2023/06/20
- Product number
- C3858
- Product name
- 1-(Cyclopropylmethyl)piperazine
- Purity
- min. 95.0 %
- Packaging
- 1G
- Price
- $42
- Updated
- 2025/07/31
- Product number
- C3858
- Product name
- 1-(Cyclopropylmethyl)piperazine
- Purity
- min. 95.0 %
- Packaging
- 5G
- Price
- $126
- Updated
- 2025/07/31
- Product number
- C986805
- Product name
- 1-(Cyclopropylmethyl)piperazine
- Packaging
- 5g
- Price
- $140
- Updated
- 2021/12/16
- Product number
- 024199
- Product name
- 1-(Cyclopropylmethyl)piperazine
- Packaging
- 500mg
- Price
- $29
- Updated
- 2021/12/16
1-(CYCLOPROPYLMETHYL)PIPERAZINE Chemical Properties,Usage,Production
Uses
1-(Cyclopropylmethyl)piperazine is a compound involved in the preparation of N-substituted piperazinopyridylsteroid derivatives as abiraterone analogs that inhibit growth and induce pro-apoptosis in human hormone-independent prostate cancer cell lines.
Synthesis
373608-50-5
57184-25-5
S3: In a 10L four-necked flask equipped with a mechanical stirrer and a thermometer, N-Boc-4-(cyclopropylmethyl)piperazine (2.00 kg, 8.32 mol) and 5 kg of isopropanol were added and heated up to 40 °C. Concentrated hydrochloric acid (2.04 kg, 20.80 mol) was slowly added dropwise, and the reaction temperature was controlled between 40°C and 50°C. After the dropwise addition, the reaction was maintained at 40°C to 50°C with stirring for 4 hours. Upon completion of the reaction, the reaction solution was concentrated to remove most of the isopropanol and cooled to 0 °C. The pH of the residue was adjusted to 10-11 with 5 mol/L aqueous sodium hydroxide. extraction was carried out with dichloromethane (5L x 3), the organic phases were combined and washed once with 5 kg of saturated aqueous sodium chloride. The organic phase was diluted with dichloromethane to give 1.11 kg of a light yellow liquid 1-cyclopropylmethylpiperazine in 94% yield. The NMR spectrum of the product was consistent with the standard spectrum.
References
[1] Patent: CN108341792, 2018, A. Location in patent: Paragraph 0030; 0035
[2] Journal of Medicinal Chemistry, 2004, vol. 47, # 11, p. 2833 - 2838
[3] Patent: EP2481739, 2012, A1. Location in patent: Page/Page column 68
[4] Patent: WO2018/5860, 2018, A1. Location in patent: Page/Page column 172; 201; 203
1-(CYCLOPROPYLMETHYL)PIPERAZINE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(CYCLOPROPYLMETHYL)PIPERAZINE manufacturers
- Product
- 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 57184-25-5
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.00%
- Supply Ability
- 100 Tons
- Release date
- 2022-02-24
- Product
- 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 57184-25-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 20kg
- Release date
- 2018-08-13
- Product
- 1-(CYCLOPROPYLMETHYL)PIPERAZINE 97 57184-25-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 100t
- Release date
- 2018-03-06