METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

Product Name: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE
CAS No.: 154825-97-5
Chemical Name: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE
Synonyms: methyl 2-(4-bromophenyl)-2-methylpropanoate;2-DIMETHYLACETATE;METHYL 2-(4-BROMOPHENYL)-2;P-Bromo-a,a-DimethylPhenylacetic;2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE;P-BROMO-ALPHA,ALPHA-DIMETHYL PHENYLACETIC;P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster;2-(4-bromophenyl)-2-methyl-propionicacidmethyle;Methyl-4-bromo alpha-alpha-dimethylbenzeneacetate;α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester
CBNumber: CB1500840
Molecular Formula: C11H13BrO2
Formula Weight: 257.12
MOL File: 154825-97-5.mol

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METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Property

Boiling point:: 290℃
Density: 1.337
vapor pressure: 0.001Pa at 40℃
Flash point:: 129℃
storage temp.: Sealed in dry,Room Temperature
solubility: Acetonitrile (Slightly), Chloroform (Slightly)
form: Oil
color: Clear Colorless to Pale Yellow
Water Solubility: 43mg/L at 20℃
InChI: InChI=1S/C11H13BrO2/c1-11(2,10(13)14-3)8-4-6-9(12)7-5-8/h4-7H,1-3H3
InChIKey: JTYDXPPFLQSEAQ-UHFFFAOYSA-N
SMILES: C1(C=CC(Br)=CC=1)C(C)(C)C(=O)OC
LogP: 3.73 at 22℃
CAS DataBase Reference: 154825-97-5

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H412Harmful to aquatic life with long lasting effects

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P273Avoid release to the environment.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

TRC

Product number: M294390
Product name: Methyl2-(4-Bromophenyl)-2,2-dimethylacetate
Packaging: 1g
Price: $95
Updated: 2021/12/16

Matrix Scientific

Product number: 074052
Product name: Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
Purity: 95+%
Packaging: 10g
Price: $165
Updated: 2021/12/16

AK Scientific

Product number: W3377
Product name: Methyl2-(4-bromophenyl)-2,2-dimethylacetate
Packaging: 1g
Price: $14
Updated: 2021/12/16

AK Scientific

Product number: J98988
Product name: Methyl2-(4-bromophenyl)-2,2-dimethylacetate
Packaging: 100g
Price: $230
Updated: 2021/12/16

Matrix Scientific

Product number: 074052
Product name: Methyl 2-(4-bromophenyl)-2,2-dimethylacetate
Purity: 95+%
Packaging: 1g
Price: $43
Updated: 2021/12/16

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METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Chemical Properties,Usage,Production

Chemical Properties

Colourless Oil

Uses

Methyl 2-(4-Bromophenyl)-2,2-dimethylacetate (cas# 154825-97-5) is a compound useful in organic synthesis.

Synthesis

41841-16-1

74-88-4

154825-97-5

Sodium hydride (60% oil dispersion, 192 mg, 4.80 mmol) was added to dry DMF (11 mL) at 0 °C to form a suspension. Subsequently, methyl 2-(4-bromophenyl)acetate (0.35 mL, 2.2 mmol) was slowly added to this suspension. After the reaction mixture was stirred continuously for 15 min at 0 °C, iodomethane (6.5 μL, 0.10 mmol) was added dropwise. After addition, stirring was continued at 0 °C for 5 min, and then raised to room temperature and stirred for 12 hours. After completion of the reaction, the reaction was quenched with 1N HCl aqueous solution (1 mL) and extracted with ethyl acetate (3 × 2 mL). The organic layers were combined, washed sequentially with water (3 × 2 mL) and saturated saline (2 mL), dried over anhydrous sodium sulfate, filtered and concentrated under reduced pressure. Finally, the residue was purified by silica gel column chromatography (eluent: 0% to 5% ethyl acetate/hexane gradient elution) to afford the target product methyl 2-(4-bromophenyl)-2-methylpropionate (550 mg, 98% yield); mass spectrometry (electrospray positive ionization mode) C10H11BrO2 Calculated value: 242/244, measured value: 243/245 [M+H]+.

References

[1] Patent: WO2014/31928, 2014, A2. Location in patent: Paragraph 0398
[2] Patent: WO2010/86820, 2010, A1. Location in patent: Page/Page column 41-42
[3] Patent: US2010/197591, 2010, A1. Location in patent: Page/Page column 24
[4] Patent: US2008/21024, 2008, A1. Location in patent: Page/Page column 80
[5] Journal of Heterocyclic Chemistry, 2011, vol. 48, # 5, p. 998 - 1005

METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Preparation Products And Raw materials

Raw materials

Preparation Products

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METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE Suppliers

Canada 1 China 136 Europe 1 Germany 3 India 6 United Kingdom 1 United States 12 Global 160

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View Lastest Price from METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE manufacturers

Anhui Dexinjia Biopharm Co., Ltd

Product: Methyl 2-(4-Bromophenyl)-2,2-Dimethylacetate 154825-97-5
Price: US $10.00-150.00/kg
Min. Order: 1kg
Purity: NLT98%
Supply Ability: 2 ton per month
Release date: 2023-08-30

Honest Joy Holdings Limited

Product: Methyl 2-(4-bromophenyl)-2,2-dimethylacetate 154825-97-5
Price: US $0.00/KG
Min. Order: 1KG
Purity: 98.2%
Supply Ability: 100 tons
Release date: 2022-02-08

Zhuozhou Wenxi import and Export Co., Ltd

Product: METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE 154825-97-5
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-06-27

154825-97-5, METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATERelated Search:

N/A DIMETHYL PHENYLPHOSPHONITE Dimethylphenylsilane 4-Bromophenylacetic acid METHYL 2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE METHYL 2-(4-BROMOPHENYL)-2,2-DI-(METHYL-D3)ACETATE 2-(4-Bromophenyl)-2-methylpropionic acid TERT-BUTYL 2-(4-BROMOPHENYL)-2-METHYLPROPIONATE

methyl 2-(4-bromophenyl)-2-methylpropanoate

Benzeneacetic acid,4-broMo-a,a-diMethyl-, Methyl ester

Benzeneacetic acid, 4-bromo-α,α-dimethyl-, methyl ester

2-(4-BROMOPHENYL)-2,2-DIMETHYLACETATE

Alf Alda di methyl Para Bromo phenyl acetic acid methyl ester

p-Bromo-alpha,alpha-Dimethylphenylacetic acid methyl ester

2-methyl-2-(p-bromophenyl)propionic acid methyl ester

P-Bromo-a,a-DimethylPhenylaceticAcidMethylEster

P-Bromo-a,a-DimethylPhenylacetic

P-BROMO-ALPHA,ALPHA-DIMETHYL PHENYLACETIC

α,α-diMethyl-(4-broMophenyl)acetic acid Methyl ester

2-(4-bromophenyl)-2-methyl-propionicacidmethyle

2-DIMETHYLACETATE

METHYL 2-(4-BROMOPHENYL)-2

Alfa, Alfa Di Methyl Para Bromo Phenyl Acetic Acid Methyl Ester

Methyl-4-bromo alpha-alpha-dimethylbenzeneacetate

154825-97-5

Intermediates

Miscellaneous Reagents

Aromatics Compounds

Aromatics