WITHANOLIDE B(P)(NEW)
- Product Name
- WITHANOLIDE B(P)(NEW)
- CAS No.
- 56973-41-2
- Chemical Name
- WITHANOLIDE B(P)(NEW)
- Synonyms
- Withanolide B;Withanolide B-RM;WITHANOLIDE B(SH);Withanolide B(AS);Lycium substance B;WITHANOLIDE B(P)(NEW);WITHANOLIDE B(SH)(NEW);Withanolide B 56973-41-2;(5a,6a,7a,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxoergosta-2,24-dien-26-oic acid d-lactone;(5α,6α,7α,22R)-6,7-Epoxy-5,22-dihydroxy-1-oxo-ergosta-2,24-dien-26-oic acid δ-lactone
- CBNumber
- CB1500956
- Molecular Formula
- C28H38O5
- Formula Weight
- 454.6
- MOL File
- 56973-41-2.mol
WITHANOLIDE B(P)(NEW) Property
- Density
- 1.206
- storage temp.
- Store at -20°C
- solubility
- Acetonitrile: 0.1 mg/ml; Methanol: 0.5 mg/ml
- form
- Solid
- color
- White to off-white
- InChIKey
- ZTEVDTFJUUJBLP-MBMSZCMESA-N
Safety
- WGK Germany
- 3
N-Bromosuccinimide Price
- Product number
- 11798
- Product name
- Withanolide B
- Packaging
- 1mg
- Price
- $81
- Updated
- 2024/03/01
- Product number
- 11798
- Product name
- Withanolide B
- Packaging
- 10mg
- Price
- $435
- Updated
- 2024/03/01
- Product number
- 11798
- Product name
- Withanolide B
- Packaging
- 5mg
- Price
- $298
- Updated
- 2024/03/01
- Product number
- SHG0005937
- Product name
- Withanolide B
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $498.01
- Updated
- 2021/12/16
- Product number
- 4492
- Product name
- Withanolide B
- Packaging
- 1mg
- Price
- $59
- Updated
- 2021/12/16
WITHANOLIDE B(P)(NEW) Chemical Properties,Usage,Production
Uses
Withanolide B is an active component of W. somnifera Dunal. Withanolide B promotes osteogenic differentiation of hBMSCs via ERK1/2 and Wnt/β-catenin signaling pathways. Withanolide B exhibits neuroprotective, anti-arthritic, anti-aging and anti-cancer effects[1][2][3].
Definition
ChEBI: Withanolide B is a withanolide.
in vivo
Withanolide B (10 mg/kg; topical administration) promotes bone healing in a rat tibial defect model[1].
| Animal Model: | Male Sprague-Dawley rats (8 weeks, 200 g) with tibial defect[1] |
| Dosage: | 10 mg/kg |
| Administration: | Injected in situ at the bone defect site at different time points (0, 3, 5, 7, and 9 days) |
| Result: | Increased the trabecular number, trabecular thickness and the thickness of the cortical bone. |
References
[1] Kuang Z, et, al. Withanolide B promotes osteogenic differentiation of human bone marrow mesenchymal stem cells via ERK1/2 and Wnt/β-catenin signaling pathways. Int Immunopharmacol. 2020 Nov;88:106960. DOI:10.1016/j.intimp.2020.106960
[2] Dubey S, et, al. Improving the inhibition of β-amyloid aggregation by withanolide and withanoside derivatives. Int J Biol Macromol. 2021 Mar 15;173:56-65. DOI:10.1016/j.ijbiomac.2021.01.094
[3] Sivanandha G, et, al. Enhanced biosynthesis of withanolides by elicitation and precursor feeding in cell suspension culture of Withania somnifera (L.) Dunal in shake-flask culture and bioreactor. PLoS One. 2014 Aug 4;9(8):e104005. DOI:10.1371/journal.pone.0104005
WITHANOLIDE B(P)(NEW) Preparation Products And Raw materials
Raw materials
Preparation Products
WITHANOLIDE B(P)(NEW) Suppliers
View Lastest Price from WITHANOLIDE B(P)(NEW) manufacturers
- Product
- Withanolide B 56973-41-2 56973-41-2
- Price
- US $18.00/g
- Min. Order
- 1g
- Purity
- ≥98%
- Supply Ability
- 1000.00 kgs
- Release date
- 2019-07-17