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N-BOC-M-PHENYLENEDIAMINE

Product Name
N-BOC-M-PHENYLENEDIAMINE
CAS No.
68621-88-5
Chemical Name
N-BOC-M-PHENYLENEDIAMINE
Synonyms
3-(Boc-amino)aniline;Boc-m-phenylenediamine;N-BOC-m-Phenylenediaimne;N-Boc-1,3-phenylenediaMine;tert-butyl (3-aminophenyl)carbam;N-BOC-M-PHENYLENEDIAMINE，98% min;tert-butyl N-(3-aMinophenyl)carbaMate;N-Boc-m-phenylenediamine;N-Boc-m-phenylenediamine >=98.0% (HPLC);1,1-Dimethylethyl (3-aminophenyl)carbamate
CBNumber
CB1502697
Molecular Formula
C11H16N2O2
Formula Weight
208.26
MOL File
68621-88-5.mol
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N-BOC-M-PHENYLENEDIAMINE Property

Melting point:
109-110℃ (dichloromethane )
Boiling point:
295.1±23.0 °C(Predicted)
Density 
1.152±0.06 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2–8 °C
solubility 
slightly sol. in Methanol
form 
powder to crystal
pka
13.57±0.70(Predicted)
color 
White to Gray to Brown
InChI
InChI=1S/C11H16N2O2/c1-11(2,3)15-10(14)13-9-6-4-5-8(12)7-9/h4-7H,12H2,1-3H3,(H,13,14)
InChIKey
IEUIEMIRUXSXCL-UHFFFAOYSA-N
SMILES
C(OC(C)(C)C)(=O)NC1=CC=CC(N)=C1
CAS DataBase Reference
68621-88-5
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Safety

Hazard Codes 
Xn
Risk Statements 
22
WGK Germany 
3
F 
10-23
HS Code 
2924297099
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
53175
Product name
N-Boc-m-phenylenediamine
Purity
≥98.0% (HPLC)
Packaging
5g
Price
$179
Updated
2025/07/31
TCI Chemical
Product number
B4222
Product name
N-(tert-Butoxycarbonyl)-1,3-phenylenediamine
Purity
>98.0%(GC)(T)
Packaging
1g
Price
$59
Updated
2025/07/31
TCI Chemical
Product number
B4222
Product name
N-(tert-Butoxycarbonyl)-1,3-phenylenediamine
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$203
Updated
2025/07/31
TRC
Product number
B663295
Product name
N-Boc-m-Phenylenediamine
Packaging
100mg
Price
$60
Updated
2021/12/16
TRC
Product number
B663295
Product name
N-Boc-m-Phenylenediamine
Packaging
500mg
Price
$75
Updated
2021/12/16
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N-BOC-M-PHENYLENEDIAMINE Chemical Properties,Usage,Production

Uses

N-Boc-m-phenylenediamine (tert-Butyl-3-aminophenylcarbamate) may be used in the preparation of:

  • 5,5′-(propane-2,2-diyl)bis(N-(3-aminophenyl)-4-methyl-3-phenyl-1H-pyrrole-2-carboxamide)
  • ethyl 4-[{3-[(tert-butoxycarbonyl)amino]phenyl}amino]-2-chloropyrimidine-5-carboxylate
  • ethyl 4-(3-(tert-butoxycarbonyl)phenylamino)-2-(methylthio)pyrimidine-5-carboxylate

reaction suitability

reagent type: cross-linking reagent

Synthesis

18437-64-4

68621-88-5

General procedure: tert-butyl (3-nitrophenyl)carbamate (10.75 g, 45.12 mmol) was used as raw material and dissolved in methanol (150 mL). To this solution, 10% Pd/C catalyst (0.48 g) was added. The reaction mixture was stirred overnight at room temperature in a hydrogen atmosphere. Upon completion of the reaction, the catalyst was removed by filtration. The filtrate was concentrated under reduced pressure to give the crude product. The crude product was purified by silica gel column chromatography with the eluent of petroleum ether/ethyl acetate (4:1, v/v) to give N-BOC-mesophenylenediamine as a light yellow solid (7.59 g, 8% yield).

References

[1] Tetrahedron Letters, 1993, vol. 34, # 49, p. 7823 - 7826
[2] Journal of Medicinal Chemistry, 1998, vol. 41, # 4, p. 623 - 639
[3] Journal of Medicinal Chemistry, 2006, vol. 49, # 7, p. 2253 - 2261
[4] Journal of the American Chemical Society, 2008, vol. 130, # 45, p. 15193 - 15202
[5] Journal of Medicinal Chemistry, 2015, vol. 58, # 1, p. 212 - 221

N-BOC-M-PHENYLENEDIAMINE Preparation Products And Raw materials

Raw materials

Preparation Products

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N-BOC-M-PHENYLENEDIAMINE Suppliers

Americas 1 China 177 Europe 2 Germany 3 India 7 Japan 1 Switzerland 2 United Kingdom 7 United States 29 Global 229
Shanghai Dano Pharmaceutical Co., LTD(China)
Tel
0592-6266840 15750707980
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sales@chemsdano.com
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China
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Mashilabs (Shanghai) Co.,Ltd.
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19916721580
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QQ：3154870176
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mafarm@126.com
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China
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J & K SCIENTIFIC LTD.
Tel
18210857532; 18210857532
Fax
86-10-82849933
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jkinfo@jkchemical.com
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China
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96815
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PharmaBlock Sciences (Nanjing),Inc.
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025-86918202 4000255188
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86-025-86918232
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sales@pharmablock.com
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China
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ZHIWE CHEMTECH CO LTD
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021-20221225 13917446399
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QQ:115820162
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zwchem@163.com
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China
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TCI (Shanghai) Development Co., Ltd.
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021-67121386
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021-67121385
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Sales-CN@TCIchemicals.com
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China
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Ark Pharm, Inc.
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847-367-3680
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sales@arkpharminc.com
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United States
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Energy Chemical
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021-021-58432009 400-005-6266
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021-58436166
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sales8178@energy-chemical.com
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China
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Beijing Ouhe Technology Co., Ltd
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010-010-82967028 13522913783
Fax
+86-10-82967029
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2355560935@qq.com
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China
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Jia Xing Isenchem Co.,Ltd
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0573-85285100 18627885956
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0573-85285100
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isenchem@163.com
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China
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View Lastest Price from N-BOC-M-PHENYLENEDIAMINE manufacturers

Shanghai Yingrui Biopharma Co.,Ltd
Product
N-BOC-M-PHENYLENEDIAMINE 68621-88-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
10Tons
Release date
2019-11-07
Shanghai Yingrui Biopharma Co.,Ltd
Product
N-BOC-M-PHENYLENEDIAMINE 68621-88-5
Price
US $0.00/Kg/Drum
Min. Order
1KG
Purity
99%
Supply Ability
10Tons
Release date
2019-11-07
Career Henan Chemical Co
Product
N-BOC-M-PHENYLENEDIAMINE 68621-88-5
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
1000KG
Release date
2018-08-15

68621-88-5, N-BOC-M-PHENYLENEDIAMINERelated Search:

(5-AMINO-2-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (3-AMINO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (5-AMINO-2-FLUORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (5-AMINO-2-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (3-BOC-AMINO-5-NITROPHENYL)BORONIC ACID (3-AMINO-4-METHYL-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (5-AMINO-2-BROMO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER BOC-3-AMINO-5-(FMOC-AMINO)-BENZOIC ACID (3-AMINO-4-FLUORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER (3-AMINO-4-CHLORO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 3,5-BIS-BOC-AMINOBENZOIC ACID (3-AMINO-4-BROMO-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER N,N-DI-TERT-BUTOXYCARBONYL-BENZENE-1,3-DIAMINE N-BOC-M-PHENYLENEDIAMINE (5-AMINO-2-METHOXY-PHENYL)-CARBAMIC ACID TERT-BUTYL ESTER 3-T-BUT-(OXYCARBOXYLAMINO-5-NITROPHENYL) CARBAMIC ACID T-BUTYL ESTER 2-TERT-BUTOXYCARBONYLAMINO-4-NITROBENZOIC ACID AURORA KA-8078

  • Carbamic acid, (3-aminophenyl)-, 1,1-dimethylethyl ester (9CI)
  • CarbaMic acid, N-(3-aMinophenyl)-, 1,1-diMethylethyl ester
  • CarbaMic acid, (3-aMinophenyl)-, 1,1-diMethylethyl ester
  • tert-butyl N-(3-aMinophenyl)carbaMate
  • 3-(tert-Butoxycarbonylamino)aniline, tert-Butyl-3-aminophenylcarbamate
  • N-Boc-1,3-phenylenediaMine
  • 1,1-Dimethylethyl (3-aminophenyl)carbamate
  • Boc-m-phenylenediamine
  • N-(tert-Butoxycarbonyl)-benzene-1,3-diamine
  • (3-aMinophenyl)carbaMic acid, 1,1-diMethylethyl ester
  • N-(tert-Butoxycarbonyl)-1,3-phenylenediaMine
  • N-BOC-m-Phenylenediaimne
  • tert-butyl (3-aminophenyl)carbam
  • N-Boc-m-phenylenediamine >=98.0% (HPLC)
  • N-(tert-Butoxycarbonyl)-1,3-phenylenediamine &gt
  • 3-(Boc-amino)aniline
  • <i>N</i>-Boc-<i>m</i>-phenylenediamine
  • N-BOC-M-PHENYLENEDIAMINE，98% min
  • 68621-88-5
  • N-BOC