2-BROMO-3-THIOPHENECARBOXYLIC ACID
Application- Product Name
- 2-BROMO-3-THIOPHENECARBOXYLIC ACID
- CAS No.
- 24287-95-4
- Chemical Name
- 2-BROMO-3-THIOPHENECARBOXYLIC ACID
- Synonyms
- EA295;2-Bromo-3-thio;2-Bromo-3-carboxythiophene;2-Bromothiophen-3-carboxylic acid;2-BROMO-3-THIOPHENECARBOXYLIC ACID;3-Thiophenecarboxylicacid, 2-broMo-;2-BROMO-3-THIOPHENECARBOXYLIC ACID 97;2-Bromothiophene-3-carboxylic acid 97%;2-Bromo-3-thiophenecarboxylic acid 97%;2-Bromo-3-thiophenecarboxylic acid≥ 98% (HPLC)
- CBNumber
- CB1505320
- Molecular Formula
- C5H3BrO2S
- Formula Weight
- 207.05
- MOL File
- 24287-95-4.mol
2-BROMO-3-THIOPHENECARBOXYLIC ACID Property
- Melting point:
- 178-182 °C(lit.)
- Boiling point:
- 313.2±27.0 °C(Predicted)
- Density
- 1.923±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 3?+-.0.20(Predicted)
- form
- Crystalline Powder
- color
- White to tan
- InChIKey
- RVSXMPCELBYUSF-UHFFFAOYSA-N
- CAS DataBase Reference
- 24287-95-4
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 638129
- Product name
- 2-Bromo-3-thiophenecarboxylic acid
- Purity
- 97%
- Packaging
- 1g
- Price
- $48.2
- Updated
- 2025/07/31
- Product number
- 638129
- Product name
- 2-Bromo-3-thiophenecarboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $178
- Updated
- 2025/07/31
- Product number
- B688553
- Product name
- 2-Bromo-3-thiophenecarboxylic acid
- Packaging
- 100mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- B688553
- Product name
- 2-Bromo-3-thiophenecarboxylic acid
- Packaging
- 500mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- OR40613
- Product name
- 2-Bromothiophene-3-carboxylicacid
- Purity
- 95%
- Packaging
- 1g
- Price
- $25
- Updated
- 2021/12/16
2-BROMO-3-THIOPHENECARBOXYLIC ACID Chemical Properties,Usage,Production
Application
2-Bromo-3-thiophenecarboxylic acid is an organic synthesis intermediate and a pharmaceutical intermediate that can be used in laboratory research and development processes as well as in chemical and pharmaceutical synthesis.
Chemical Properties
Light yellow crystalline powder
Synthesis
88-13-1
24287-95-4
General procedure for the synthesis of 2-bromo-3-thiophenecarboxylic acid from 3-thiophenecarboxylic acid: 3-thiophenecarboxylic acid (2.00 g, 15.6 mmol) and anhydrous tetrahydrofuran (THF; 30 mL) were added to a pre oven-dried 100 mL round bottom flask. The reaction system was cooled to -78.0 °C and a 2.50 M hexane solution of n-butyllithium (12.6 mL, 31.5 mmol) was added slowly and dropwise under nitrogen protection. The reaction mixture was stirred at -78.0 °C for 30 min before adding bromine (0.86 mL, 16.4 mmol) dropwise. Stirring was continued at -78.0 °C for 1 h. The reaction system was then slowly warmed to room temperature. After stirring overnight, dilute 1M HCl solution (50.0 mL) was added to quench the reaction, followed by concentration of the reaction solution. The resulting mixture was extracted with ether and water and the organic layer was dried with anhydrous Na2SO4. The product was recrystallized twice by H2O/ether mixed solvent to give pale yellow needle-like crystals of 2-bromo-3-thiophenecarboxylic acid (2.13 g, 66.0% yield). The structure of the product was confirmed by 1H NMR (500 MHz, DMSO-d6): δ 7.63-7.62 (d, J=5.8 Hz, 1H), 7.32-7.31 (d, J=5.8 Hz, 1H).
References
[1] Journal of Organic Chemistry, 2002, vol. 67, # 20, p. 6931 - 6937
[2] Polymer, 2018, vol. 146, p. 142 - 150
[3] Patent: CN106588868, 2017, A. Location in patent: Paragraph 0025-0029; 0043; 0053-0055
2-BROMO-3-THIOPHENECARBOXYLIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
2-BROMO-3-THIOPHENECARBOXYLIC ACID Suppliers
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- fo@acros.com
- Country
- Belgium
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- Advantage
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View Lastest Price from 2-BROMO-3-THIOPHENECARBOXYLIC ACID manufacturers
- Product
- 2-BROMO-3-THIOPHENECARBOXYLIC ACID 97 24287-95-4
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10 mt
- Release date
- 2024-12-05
- Product
- 2-BROMO-3-THIOPHENECARBOXYLIC ACID 97 24287-95-4
- Price
- US $1.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2018-12-18