ChemicalBook > CAS DataBase List > 5-Chloro-2-thiophenecarboxylic Acid
5-Chloro-2-thiophenecarboxylic Acid
- Product Name
- 5-Chloro-2-thiophenecarboxylic Acid
- CAS No.
- 24065-33-6
- Chemical Name
- 5-Chloro-2-thiophenecarboxylic Acid
- Synonyms
- 5-Chlorothiophene-2-carboxylic;5-chloro-2-thiophenecarboxylicaci;5-Chlorothiophen-2-carboxylic acid;5-CHLORO-2-THIOPHENECARBOXYLIC ACID;NSC 14776;AKOS B000092;Rivaroxaban F;2-Amino-9-picoline;RARECHEM AL BE 0303;TIMTEC-BB SBB003937
- CBNumber
- CB3189269
- Molecular Formula
- C5H3ClO2S
- Formula Weight
- 162.59
- MOL File
- 24065-33-6.mol
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5-Chloro-2-thiophenecarboxylic Acid Property
- Melting point:
- 154-158 °C(lit.)
- Boiling point:
- 287.0±20.0 °C(Predicted)
- Density
- 1.466 (estimate)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- DMSO (Slightly), Methanol (Slightly)
- pka
- 3.32±0.10(Predicted)
- form
- Powder
- color
- Cream-yellow
- BRN
- 118361
- InChI
- InChI=1S/C5H3ClO2S/c6-4-2-1-3(9-4)5(7)8/h1-2H,(H,7,8)
- InChIKey
- QZLSBOVWPHXCLT-UHFFFAOYSA-N
- SMILES
- C1(C(O)=O)SC(Cl)=CC=1
- CAS DataBase Reference
- 24065-33-6(CAS DataBase Reference)
- NIST Chemistry Reference
- 5-Chloro-2-thiophenecarboxylic acid(24065-33-6)
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Safety
- Hazard Codes
- Xi
- Risk Statements
- 36-43-36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- XM8400000
- HazardClass
- IRRITANT
- HS Code
- 29349990
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Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H317May cause an allergic skin reaction
H319Causes serious eye irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 633003
- Product name
- 5-Chlorothiophene-2-carboxylic acid
- Purity
- 97%
- Packaging
- 5g
- Price
- $31.2
- Updated
- 2024/03/01
Sigma-Aldrich
- Product number
- 633003
- Product name
- 5-Chlorothiophene-2-carboxylic acid
- Purity
- 97%
- Packaging
- 25g
- Price
- $36.48
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C1230
- Product name
- 5-Chlorothiophene-2-carboxylic Acid
- Purity
- >95.0%(GC)(T)
- Packaging
- 5g
- Price
- $17
- Updated
- 2024/03/01
TCI Chemical
- Product number
- C1230
- Product name
- 5-Chlorothiophene-2-carboxylic Acid
- Purity
- >95.0%(GC)(T)
- Packaging
- 25g
- Price
- $49
- Updated
- 2024/03/01
Alfa Aesar
- Product number
- A15209
- Product name
- 5-Chlorothiophene-2-carboxylic acid, 98%
- Packaging
- 5g
- Price
- $29.65
- Updated
- 2024/03/01
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5-Chloro-2-thiophenecarboxylic Acid Chemical Properties,Usage,Production
Chemical Properties
White to light yellow crystal powder
Uses
A metabolite of Rivaroxaban (R538000).
Uses
5-Chlorothiophene-2-carboxylic acid can be used in the synthesis of the following:
- rivaroxaban, an oxazolidinone derivative used in the treatment of thromboembolic disorders
- 5-chloro-4-nitrothiophene-2-carboxylic acid, which can be used in the synthesis of thieno[2,3-b][1,4]thiapezine-5-ones
Synthesis
The compound 5-chlorothiophene-2-carboxylic acid is a crucial intermediate in the synthesis of rivaroxaban. Due to its significance, numerous researchers have investigated various methods of synthesizing it. The synthesis of this compound involves the utilization of different starting materials, namely, 2-chlorothiophene, 2-chloro-5-bromothiophene, and 5-chloro-2-acetylthiophene, depending on the specific approach employed.
1. This method takes 2-chlorothiophene as an initial raw material, carrying out Friedel-crafts acylation with trichloroacetyl chloride under the action of aluminum trichloride to generate 2-trichloroacetyl-5-chlorothiophene, and then carrying out liquid alkali hydrolysis to obtain a target product.
2. This method reacts 5-chloro-2-bromothiophene with magnesium to generate a Grignard reagent, introducing carbon dioxide for inserting carbonyl and performing acid-base treatment to obtain a product.
3. 5-chloro-2-acetylthiophene is used as a raw material and is oxidized by sodium chlorite and potassium dihydrogen phosphate system to obtain a target compound.
5-Chloro-2-thiophenecarboxylic Acid Preparation Products And Raw materials
Raw materials
2-Chlorothiophene
Nitrogen
2,5-Dichlorothiophene
Diethyl ether
Sulfuric acid
n-Butyllithium
Sodium carbonate
Preparation Products
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5-Chloro-2-thiophenecarboxylic Acid Suppliers
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- 18519331287
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View Lastest Price from 5-Chloro-2-thiophenecarboxylic Acid manufacturers
Hebei Dangtong Import and export Co LTD
- Product
- 5-CHLOROTHIOPHENE-2-CARBOXYLIC ACID 24065-33-6
- Price
- US $300.00-260.00/kg
- Min. Order
- 100kg
- Purity
- 99.99%
- Supply Ability
- 100Tons
- Release date
- 2023-03-06
airuikechemical co., ltd.
- Product
- 5-Chloro-2-thiophenecarboxylic acid 24065-33-6
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 20 tons
- Release date
- 2024-04-07
PNP Biotech Co. Ltd
- Product
- 5-Chloro-2-thiophenecarboxylic acid 24065-33-6
- Price
- US $0.00/KG
- Min. Order
- 25KG
- Purity
- 98%-99%
- Supply Ability
- Inquiry
- Release date
- 2022-10-21
24065-33-6, 5-Chloro-2-thiophenecarboxylic AcidRelated Search:
Rivaroxaban Impurity 43
2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione
AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
2-Thiophenecarboxylic acid
(S)-2-(3-chloro-2-hydroxypropyl)isoindoline-1,3-dione
4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]-
Rivaroxaban Impurity 41
(S)-2-(2-(5-chloro-N-(4-(5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)thiophene-2-carboxamido)ethoxy)acetic acid
(S)-(+)-Glycidyl Phthalimide
4-(4-NITROPHENYL)MORPHOLIN-3-ONE
Rivaroxaban Impurity 36
2-Chloro-5-thiophenecarboxaldehyde
Rivaroxaban Impurity 34
Rivaroxaban iMpurity 5
Rivaroxaban Impurity 38
Rivaroxaban Impurity 44
Rivaroxaban Impurity 48