2-Thiophenecarboxylic acid
- Product Name
- 2-Thiophenecarboxylic acid
- CAS No.
- 527-72-0
- Chemical Name
- 2-Thiophenecarboxylic acid
- Synonyms
- THIOPHENE-2-CARBOXYLIC ACID;thiophene-2-carboxylate;2-THENOIC ACID;2-TCA;THENOIC ACID;AKOS B022791;2-Thenoesure;2-THIOPHENIC ACID;AKOS BBS-00003739;ALPHA-THENOIC ACID
- CBNumber
- CB1778926
- Molecular Formula
- C5H4O2S
- Formula Weight
- 128.15
- MOL File
- 527-72-0.mol
2-Thiophenecarboxylic acid Property
- Melting point:
- 125-127 °C(lit.)
- Boiling point:
- 260 °C(lit.)
- Density
- 1.42
- refractive index
- 1.5160 (estimate)
- Flash point:
- 259-261°C
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- solubility
- Acetone (Slightly), Chloroform (Slightly)
- form
- solid
- pka
- 3.49(at 25℃)
- color
- White to Off-White
- Water Solubility
- 80 g/L (20 ºC)
- Merck
- 14,9354
- BRN
- 110150
- InChIKey
- QERYCTSHXKAMIS-UHFFFAOYSA-N
- LogP
- 1.570
- CAS DataBase Reference
- 527-72-0(CAS DataBase Reference)
- NIST Chemistry Reference
- 2-Thiophenecarboxylic acid(527-72-0)
- EPA Substance Registry System
- 2-Thiophenecarboxylic acid (527-72-0)
Safety
- Hazard Codes
- Xi
- Risk Statements
- 36/37/38
- Safety Statements
- 26-36-37/39
- WGK Germany
- 3
- RTECS
- XM8330200
- Hazard Note
- Irritant
- TSCA
- Yes
- HS Code
- 29349990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- T32603
- Product name
- 2-Thiophenecarboxylic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 25g
- Price
- $38.5
- Updated
- 2024/03/01
- Product number
- T32603
- Product name
- 2-Thiophenecarboxylic acid
- Purity
- ReagentPlus , 99%
- Packaging
- 100g
- Price
- $81.6
- Updated
- 2024/03/01
- Product number
- T0218
- Product name
- 2-Thiophenecarboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 25g
- Price
- $53
- Updated
- 2024/03/01
- Product number
- T0218
- Product name
- 2-Thiophenecarboxylic Acid
- Purity
- >98.0%(T)
- Packaging
- 100g
- Price
- $159
- Updated
- 2024/03/01
- Product number
- A12514
- Product name
- Thiophene-2-carboxylic acid, 99%
- Packaging
- 25g
- Price
- $21.65
- Updated
- 2024/03/01
2-Thiophenecarboxylic acid Chemical Properties,Usage,Production
Chemical Properties
The substance is a light yellow crystal powder. It dissolves in hot water, ethanol, and ether, and is only slightly soluble in chloroform.
Uses
2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.
Production Methods
Thiophene 2-Carboxylic Acid, T2CA, is prepared via oxidation of 2-acetylthiophene using hypochlorite, because oxidation of alkylthiophenes leads to general breakdown of the thiophene ring.
Definition
ChEBI: Thiophene-2-carboxylic acid is a thiophenecarboxylic acid in which the carboxy group is located at position 2. It is a conjugate acid of a thiophene-2-carboxylate.
Application
The sodium salt of 2-Thiophenecarboxylic acid(T2CA) is used to treat influenza (trophires). Other salts, e.g., the Li salt, have minor medicinal uses and the free acid is a mucolytic. A US Patent describes the use of the Na salt as a lubricating oil thickener. ?Suprofen, a nonsteroidal anti-inflammatory (NSAI), and tienilic acid (ticrynafen), a potent diuretic, were both very large prospective markets for T2CA or its acid chloride, but were almost completely withdrawn in the 1980s. Sanofi Aventis'NSAI tiaprofenic acid was comparatively successful in this market, but although it is still marketed it has subsequently been superceded by alternative products. The 5-nitro derivative of T2CA is used to produce nifurzide, an intestinal antibacterial. Pfizer's anti-inflammatory tenidap is a developing drug which uses the acid chloride of T2CA as the starting intermediate.
Synthesis Reference(s)
The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055
Purification Methods
Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]
2-Thiophenecarboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 2-Thiophenecarboxylic acid manufacturers
- Product
- 2-Thiophenecarboxylic acid 527-72-0
- Price
- US $10.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 20 ton
- Release date
- 2024-12-03
- Product
- 2-Thiophenic acid 527-72-0
- Price
- US $6.00-49.00/g
- Min. Order
- 1000g
- Purity
- 0.98
- Supply Ability
- 1000kg
- Release date
- 2024-08-23
- Product
- 2-Thiophenecarboxylic acid 527-72-0
- Price
- US $0.00-0.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 500000kg
- Release date
- 2024-10-30