2-Thiophenecarboxylic acid

Product Name: 2-Thiophenecarboxylic acid
CAS No.: 527-72-0
Chemical Name: 2-Thiophenecarboxylic acid
Synonyms: THIOPHENE-2-CARBOXYLIC ACID;thiophene-2-carboxylate;2-THENOIC ACID;2-TCA;THENOIC ACID;AKOS B022791;2-Thenoesure;2-THIOPHENIC ACID;AKOS BBS-00003739;ALPHA-THENOIC ACID
CBNumber: CB1778926
Molecular Formula: C5H4O2S
Formula Weight: 128.15
MOL File: 527-72-0.mol

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2-Thiophenecarboxylic acid Property

Melting point:: 125-127 °C(lit.)
Boiling point:: 260 °C(lit.)
Density: 1.42
refractive index: 1.5160 (estimate)
Flash point:: 259-261°C
storage temp.: Keep in dark place,Sealed in dry,Room Temperature
solubility: Acetone (Slightly), Chloroform (Slightly)
form: solid
pka: 3.49(at 25℃)
color: White to Off-White
Water Solubility: 80 g/L (20 ºC)
Merck: 14,9354
BRN: 110150
InChIKey: QERYCTSHXKAMIS-UHFFFAOYSA-N
LogP: 1.570
CAS DataBase Reference: 527-72-0(CAS DataBase Reference)
NIST Chemistry Reference: 2-Thiophenecarboxylic acid(527-72-0)
EPA Substance Registry System: 2-Thiophenecarboxylic acid (527-72-0)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
RTECS: XM8330200
Hazard Note: Irritant
TSCA: Yes
HS Code: 29349990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T32603
Product name: 2-Thiophenecarboxylic acid
Purity: ReagentPlus , 99%
Packaging: 25g
Price: $38.5
Updated: 2024/03/01

Sigma-Aldrich

Product number: T32603
Product name: 2-Thiophenecarboxylic acid
Purity: ReagentPlus , 99%
Packaging: 100g
Price: $81.6
Updated: 2024/03/01

TCI Chemical

Product number: T0218
Product name: 2-Thiophenecarboxylic Acid
Purity: >98.0%(T)
Packaging: 25g
Price: $53
Updated: 2024/03/01

TCI Chemical

Product number: T0218
Product name: 2-Thiophenecarboxylic Acid
Purity: >98.0%(T)
Packaging: 100g
Price: $159
Updated: 2024/03/01

Alfa Aesar

Product number: A12514
Product name: Thiophene-2-carboxylic acid, 99%
Packaging: 25g
Price: $21.65
Updated: 2024/03/01

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2-Thiophenecarboxylic acid Chemical Properties,Usage,Production

Chemical Properties

The substance is a light yellow crystal powder. It dissolves in hot water, ethanol, and ether, and is only slightly soluble in chloroform.

Uses

2-Thenoic Acid, is a sulfur-containing heterocyclic compound, used in the synthesis of pharmaceutical and biologically active compounds. It is also shown to be utilized by presumptive Rhodococcus bacterium in soil, as a sole source of carbon.

Production Methods

Thiophene 2-Carboxylic Acid, T2CA, is prepared via oxidation of 2-acetylthiophene using hypochlorite, because oxidation of alkylthiophenes leads to general breakdown of the thiophene ring.

Definition

ChEBI: Thiophene-2-carboxylic acid is a thiophenecarboxylic acid in which the carboxy group is located at position 2. It is a conjugate acid of a thiophene-2-carboxylate.

Application

The sodium salt of 2-Thiophenecarboxylic acid(T2CA) is used to treat influenza (trophires). Other salts, e.g., the Li salt, have minor medicinal uses and the free acid is a mucolytic. A US Patent describes the use of the Na salt as a lubricating oil thickener. ?Suprofen, a nonsteroidal anti-inflammatory (NSAI), and tienilic acid (ticrynafen), a potent diuretic, were both very large prospective markets for T2CA or its acid chloride, but were almost completely withdrawn in the 1980s. Sanofi Aventis'NSAI tiaprofenic acid was comparatively successful in this market, but although it is still marketed it has subsequently been superceded by alternative products. The 5-nitro derivative of T2CA is used to produce nifurzide, an intestinal antibacterial. Pfizer's anti-inflammatory tenidap is a developing drug which uses the acid chloride of T2CA as the starting intermediate.

Synthesis Reference(s)

The Journal of Organic Chemistry, 30, p. 3520, 1965 DOI: 10.1021/jo01021a055

Purification Methods

Crystallise the acid from water and dry it in a vacuum. The amide has m 181o(from H2O) and pK2 5 10.54(50% aqueous dioxane). [Beilstein 18 H 289, 18 I 438, 18 II 269, 18 III/IV 4011, 18/6 V 158.]

2-Thiophenecarboxylic acid Preparation Products And Raw materials

Raw materials

Preparation Products

BIS(2-THIENYL) KETONE 5-Nitrothiophene-2-carboxylic acid 2-THIOPHENECARBOXYLIC ACID SODIUM SALT 7-DIETHYLAMINO-3-THENOYLCOUMARIN 5-BROMOTHIOPHENE-2-CARBONITRILE 5-TERT-BUTYL-THIOPHENE-2-CARBOXYLIC ACID 5-Bromo-2-thiophenecarboxylic acid 2-THIOPHENAMINE 3-BROMOTHIOPHENE-2-CARBOXAMIDE 3-(THIOPHEN-2-YL)ISOXAZOL-5-AMINE

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2-Thiophenecarboxylic acid Suppliers

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View Lastest Price from 2-Thiophenecarboxylic acid manufacturers

Hebei Zhuanglai Chemical Trading Co Ltd

Product: 2-Thiophenecarboxylic acid 527-72-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20 ton
Release date: 2024-12-03

Shanghai UCHEM Inc.

Product: 2-Thiophenic acid 527-72-0
Price: US $6.00-49.00/g
Min. Order: 1000g
Purity: 0.98
Supply Ability: 1000kg
Release date: 2024-08-23

Hebei Weibang Biotechnology Co., Ltd

Product: 2-Thiophenecarboxylic acid 527-72-0
Price: US $0.00-0.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 500000kg
Release date: 2024-10-30

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