5-Nitrothiophene-2-carboxylic acid
- Product Name
- 5-Nitrothiophene-2-carboxylic acid
- CAS No.
- 6317-37-9
- Chemical Name
- 5-Nitrothiophene-2-carboxylic acid
- Synonyms
- BUTTPARK 121\04-13;5 - nitro-thiophene;RARECHEM AL BO 0544;5-Nitro-2-thenoic acid;2-Carboxy-5-nitrothiophe;2-Carboxy-5-nitrothiophene;5-nitro-2-thiophenecarboxylic;5-Nitro-2-ThiphenecarboxylicAcid;5-Nitrothiophene-2-carboxylicaci;5-Nitro-2thiaphene-carboxylic acid
- CBNumber
- CB2197443
- Molecular Formula
- C5H3NO4S
- Formula Weight
- 173.15
- MOL File
- 6317-37-9.mol
5-Nitrothiophene-2-carboxylic acid Property
- Melting point:
- 154-159℃
- Boiling point:
- 367.2±27.0 °C(Predicted)
- Density
- 1.676±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Sealed in dry,Room Temperature
- pka
- 2.69±0.10(Predicted)
- form
- Solid
- color
- Pale yellow
- InChIKey
- UNEPVPOHGXLUIR-UHFFFAOYSA-N
- CAS DataBase Reference
- 6317-37-9(CAS DataBase Reference)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405Store locked up.
N-Bromosuccinimide Price
- Product number
- N0940
- Product name
- 5-Nitro-2-thiophenecarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 5g
- Price
- $64
- Updated
- 2025/07/31
- Product number
- N0940
- Product name
- 5-Nitro-2-thiophenecarboxylic Acid
- Purity
- >97.0%(GC)(T)
- Packaging
- 25g
- Price
- $255
- Updated
- 2025/07/31
- Product number
- N506010
- Product name
- 5-Nitrothiophene-2-carboxylic acid
- Packaging
- 5g
- Price
- $165
- Updated
- 2021/12/16
- Product number
- 8H54-1-X1
- Product name
- 5-Nitrothiophene-2-carboxylic acid
- Packaging
- 1g
- Price
- $16
- Updated
- 2021/12/16
- Product number
- 073115
- Product name
- 5-Nitrothiophene-2-carboxylic acid
- Purity
- 95+%
- Packaging
- 1g
- Price
- $20
- Updated
- 2021/12/16
5-Nitrothiophene-2-carboxylic acid Chemical Properties,Usage,Production
Chemical Properties
Solid
Uses
5-Nitrothiophene-2-carboxylic Acid is a reagent used in the preparation of benzothiophene amides which fuctions as nicotinamide ribosyltransferase inhibitors with potential antitumor and anticancer activities. It also functions as an intermediate in varying organic transformations.
Synthesis Reference(s)
Canadian Journal of Chemistry, 44, p. 2881, 1966 DOI: 10.1139/v66-428
Journal of Medicinal Chemistry, 34, p. 2112, 1991
Synthesis
4521-33-9
6317-37-9
General procedure for the synthesis of 5-nitrothiophene-2-carboxylic acid from 5-nitrothiophene-2-carboxaldehyde: 5-nitrothiophene-2-carboxaldehyde (1.685 g, 10.72 mmol) was dissolved in dioxane (30 mL) with sulfamic acid (1.249 g, 12.87 mmol) and cooled down to 0 °C. Subsequently, an aqueous solution of sodium chlorite (1.940 g, 21.44 mmol) was added slowly and dropwise (14 mL). The reaction mixture was gradually warmed to room temperature and stirred continuously for 2 hours. A second batch of 5-nitrothiophene-2-carbaldehyde (1.966 g, 12.51 mmol) was treated at the same molar ratio under the same conditions. The two reaction mixtures were combined and extracted by partitioning with ethyl acetate and water. The organic phase was extracted twice with 5% NaHCO3 solution and discarded. The basic aqueous phase was adjusted to pH=2 with 2N HCl and extracted twice with ethyl acetate. The organic layers were combined, washed with brine and dried over anhydrous sodium sulfate. The solvent was removed by concentration under reduced pressure to give 5-nitrothiophene-2-carboxylic acid (Int.53) (3.6 g, 20.79 mmol, MS/ESI+ 173.9 [MH]+).
References
[1] Patent: US4220793, 1980, A
[2] Patent: US4220793, 1980, A
[3] Patent: US4220793, 1980, A
[4] Patent: WO2004/18480, 2004, A1. Location in patent: Page 155
[5] Helvetica Chimica Acta, 2002, vol. 85, # 12, p. 4485 - 4517
5-Nitrothiophene-2-carboxylic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 5-Nitrothiophene-2-carboxylic acid manufacturers
- Product
- 5-Nitrothiophene-2-carboxylic acid 6317-37-9
- Price
- US $0.00-0.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 1 ton
- Release date
- 2023-12-26
- Product
- 5-nitrothiophene-2-carboxylic acid 6317-37-9
- Price
- US $750.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 200kg
- Release date
- 2022-10-13
- Product
- 5-Nitro-2-Thiophenecarboxylic Acid 6317-37-9
- Price
- US $55.00-800.00/g
- Min. Order
- 100g
- Purity
- 99%
- Supply Ability
- 500KG/Month
- Release date
- 2021-08-09