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(S)-(+)-Glycidyl Phthalimide

Product Name
(S)-(+)-Glycidyl Phthalimide
CAS No.
161596-47-0
Chemical Name
(S)-(+)-Glycidyl Phthalimide
Synonyms
PHTHAL;(S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE;S-Glycidyl Phthalamide;(S)-N-Glycidylphthalimide;2-[[(2S)-oxiran-2-yl]methyl]isoindoline-1,3-dione;2-[(2S)-ox;(S)-(+)-GL;2-Amino-8-picoline;Rivaroxaban Impurity R;Linezolid EPP Impurity
CBNumber
CB7273483
Molecular Formula
C11H9NO3
Formula Weight
203.19
MOL File
161596-47-0.mol
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(S)-(+)-Glycidyl Phthalimide Property

Melting point:
102 °C
Boiling point:
347.4±15.0 °C(Predicted)
Density 
1.446±0.06 g/cm3(Predicted)
vapor pressure 
0.001-2.17Pa at 25-90.25℃
refractive index 
10 ° (C=2.2, CHCl3)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
solubility 
Chloroform (Slightly), Ethyl Acetate (Slightly)
pka
-2.24±0.20(Predicted)
form 
Solid
color 
White
optical activity
Consistent with structure
InChI
InChI=1S/C11H9NO3/c13-10-8-3-1-2-4-9(8)11(14)12(10)5-7-6-15-7/h1-4,7H,5-6H2/t7-/m0/s1
InChIKey
DUILGEYLVHGSEE-ZETCQYMHSA-N
SMILES
C1(=O)C2=C(C=CC=C2)C(=O)N1C[C@H]1CO1
LogP
1.2 at 40℃
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Safety

Hazard Codes 
Xi
Risk Statements 
41
Safety Statements 
26-39
WGK Germany 
2
HS Code 
29252900
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Danger
Hazard statements

H318Causes serious eye damage

H341Suspected of causing genetic defects

Precautionary statements

P201Obtain special instructions before use.

P202Do not handle until all safety precautions have been read and understood.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P308+P313IF exposed or concerned: Get medical advice/attention.

P405Store locked up.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
671606
Product name
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide
Purity
≥99.0% (GC)
Packaging
1g
Price
$31.4
Updated
2023/06/20
TCI Chemical
Product number
G0328
Product name
(S)-N-Glycidylphthalimide
Purity
>98.0%(GC)
Packaging
5g
Price
$44
Updated
2025/07/31
TCI Chemical
Product number
G0328
Product name
(S)-N-Glycidylphthalimide
Purity
>98.0%(GC)
Packaging
25g
Price
$126
Updated
2025/07/31
TRC
Product number
G615960
Product name
N-(S)-Glycidylphthalimide
Packaging
25g
Price
$215
Updated
2021/12/16
Matrix Scientific
Product number
121174
Product name
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide
Purity
97%
Packaging
25g
Price
$480
Updated
2021/12/16
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(S)-(+)-Glycidyl Phthalimide Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

(S)-(+)-Glycidyl Phthalimide is a phthalimide derivative used as an intermediate in the preparation of the antibiotic Linezolid (L466500). It is also a key intermediate of rivaroxaban.

Synthesis

Phthalimide and (S)-1-substituent propylene oxide are used as raw materials, a reaction occurs under the action of a catalyst to generate 2-((S)-3-substituent-2-hydroxypropyl isodihydroindole-1,3-dione, and finally (S)-glycidyl phthalimide is generated by means of a ring-closure reaction.

References

[1] Patent: WO2004/112787, 2004, A1. Location in patent: Page 17-18
[2] Patent: WO2004/113301, 2004, A1. Location in patent: Page 18
[3] Tetrahedron Asymmetry, 1996, vol. 7, # 6, p. 1641 - 1648
[4] Heterocycles, 2006, vol. 67, # 2, p. 561 - 566
[5] Chemical communications (Cambridge, England), 2003, # 4, p. 468 - 469

(S)-(+)-Glycidyl Phthalimide Preparation Products And Raw materials

Raw materials

Preparation Products

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(S)-(+)-Glycidyl Phthalimide Suppliers

Americas 1 Canada 1 China 543 Europe 1 Germany 3 India 88 Japan 5 Switzerland 2 United Kingdom 2 United States 30 Global 676
Bayee Biotech (Anqing) Co., Ltd.
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0556-5032306 18917961636
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Jilin Lianben Technology Development Co., Ltd
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Chembest Research Laboratories Limited
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+86-21-20908456
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TCI (Shanghai) Development Co., Ltd.
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021-67121385
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Sales-CN@TCIchemicals.com
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View Lastest Price from (S)-(+)-Glycidyl Phthalimide manufacturers

Handan City Zechi trading Co., LTD
Product
(S)-(+)-Glycidyl Phthalimide 161596-47-0
Price
US $1.00/g
Min. Order
100g
Purity
99
Supply Ability
1000
Release date
2025-08-11
WUHAN FORTUNA CHEMICAL CO., LTD
Product
(S)-(+)-N-(2,3-Epoxypropyl)phthalimide 161596-47-0
Price
US $0.00/g
Min. Order
1g
Purity
98.0%
Supply Ability
10kg/month
Release date
2021-12-17
HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD
Product
(S)-(+)-Glycidyl Phthalimide 161596-47-0
Price
US $100.00-75.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
5000Ton
Release date
2024-08-13

161596-47-0, (S)-(+)-Glycidyl PhthalimideRelated Search:

N-(Chloromethyl)phthalimide 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Rivaroxaban Impurity 43 Rivaroxaban Impurity 34 1,2-Cyclohexanedione 4-(4-NITROPHENYL)MORPHOLIN-3-ONE 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Rivaroxaban iMpurity 5 AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- Rivaroxaban Impurity 38 (S)-(+)-Epichlorohydrin

  • (S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE
  • (S)-(+)-GLYCIDYL PHTHALIMIDE
  • (S)-GLYCIDYL PHTHALIMIDE
  • 2-[[(2S)-oxiran-2-yl]methyl]isoindole-1,3-dione
  • Rivaroxaban Impurity 39
  • 2-((2S)-OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE
  • (S)-(+)-N-(2,3-Epoxypropyl)phthalimide
  • (S)-N-Glycidylphthalimide
  • 2-[(2S)-oxiran-2-ylmethyl]-1H-isoindole-1,3(2H)-dione
  • Rivaroxaban Intermediate 2
  • 2-[(2S)-ox
  • 2-[(2S)-2-oxiranyl Methyl]-1H-isoindole-1,3(2H)-dione
  • (2S)-2-(OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE
  • (S)-2-OXIRANYLMETHYL-ISOINDOLE-1,3-DIONE (S)-(+)-GLYCIDYL PHTHALIMIDE (S)-GLYCIDYL PHTHALIMIDE 2-((2S)-OXIRANYLMETHYL)-1H-ISOINDOLE-1,3(2H)-DIONE
  • 2-[(2S)-ox 2-[(2S)-2-oxiranyl Methyl]-1H-isoindole-1,3(2H)-dione
  • (S)-4-(oxiran-2-ylMethyl)isoindoline-1,3-dione
  • 1H-Isoindole-1,3(2H)-dione, 2-[(2S)-2-oxiranylMethyl]-
  • N-(S)-Glycidylphthalimide
  • (S)-(+)-N-(2,3-Epoxypropyl)pthalaMide
  • (S)-N-GlycidylphthaliMide, ee: 97.5%
  • (S)-(+)-N-(2,3-Epoxypropyl)phthaliMide >=99.0% (GC)
  • (S)-N-GlycidylphthaliMide, ee: 98%
  • (S)-(+)-GLYCIDYL PHTHALIdime
  • (S)-N-Glycidylphthalimide, 98.5%, ee: 97.5%
  • (S)-N-Glycidylphthalimide, 98.5%, ee: 98%
  • PHTHAL
  • Rivaroxaban Impurity R
  • Linezolid EPP Impurity
  • 2-{[(2S)-oxiran-2-yl]methyl}-2,3-dihydro-1H-isoindole-1,3-dione
  • (S)-(+)-GLYCIDYL PHTHALIMIDEONE
  • (S)-N-Glycidylphthalimide&gt
  • (S)-(+)-GL
  • S-Glycidyl Phthalamide
  • (S)-(+)-GLYCIDYL PHTHALIMIDE ISO 9001：2015 REACH
  • Rivaroxaban intermediates，(S)-(+)-Glycidyl Phthalimide
  • (S)- (+) - (2,3-Epoxypropyl) phthalimide
  • 2-Amino-8-picoline
  • 2-[[(2S)-oxiran-2-yl]methyl]isoindoline-1,3-dione
  • (S)-N-Glycidylphthalimide, ≥99%
  • (s)-2-oxiranylmethyl-isoindole-1,3-dione/(S)-(+)-Glycidyl Phthalimide
  • (2S)-2-Oxiranylmethyl-isoindole-1,3-dione
  • (S)-2-Oxiranylmethyl-isoindole-1,3-dione (or) (S) (+)- Glycidyl Phthalimide
  • S)-2-(Oxiran-2-ylmethyl)isoindoline-1,3-ion
  • 2-[(2s)-oxirane-2yl methyl]-1H-isoindole-1,3(2H)-dione
  • ( S ) -2- ( Oxiran - 2 - ylmethyl ) -1H - isoindole - 1,3 ( 2H ) dione
  • (S)-Glycidyl Phthalimide or (S)-2-(oxiran-2-ylmethyl)isoindoline-1,3-dione
  • 2-(((S)-Oxiran-2yl)Methyl)Isoindoline-1,3-Dione
  • (S)-2-(oxiran-2-ylmethyl isoindoline-1,3-dione (or) (S)-N-Glycidylphthalimide
  • (S)-N-Glycidylphthalimide, ≥ 98.0%
  • (S)-(+)-N-(2,3-Epoxypropyl)phthalimide or (S)-N-Glycidylphthalimide
  • (S)-N-Glycidylphthalimide, 10 mM in DMSO
  • (<i>S</i>)-(+)-<i>N</i>-(2,3-Epoxypropyl)phthalimide
  • (S)-(+)-N-(2,3-Epooypropyl)pththalimide
  • S(+) -Glycidyl phthamide
  • 161596-47-0
  • 161592-47-0
  • 61596-47-0
  • Intermediate of Rivaroxaban