Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Product Name: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
CAS No.: 141942-85-0
Chemical Name: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms: ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric
CBNumber: CB5188978
Molecular Formula: C7H11NO3
Formula Weight: 157.17
MOL File: 141942-85-0.mol

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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Property

alpha: -5 º (neat)
Boiling point:: 270 °C(lit.)
Density: 1.114 g/mL at 25 °C(lit.)
refractive index: n20/D 1.448(lit.)
Flash point:: >230 °F
storage temp.: 2-8°C
solubility: Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka: 13.03±0.20(Predicted)
form: Liquid
Specific Gravity: 1.114
color: Colorless to yellow
optical activity: [α]25/D 5°, neat
BRN: 5328715
InChIKey: LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference: 141942-85-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 1
HS Code: 29269090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 479772
Product name: Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate
Purity: 95%
Packaging: 5g
Price: $87.2
Updated: 2023/06/20

TCI Chemical

Product number: C1474
Product name: Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity: >97.0%(GC)
Packaging: 1g
Price: $16
Updated: 2024/03/01

TCI Chemical

Product number: C1474
Product name: Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity: >97.0%(GC)
Packaging: 5g
Price: $35
Updated: 2024/03/01

Alfa Aesar

Product number: L19771
Product name: Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging: 5g
Price: $43.65
Updated: 2024/03/01

Alfa Aesar

Product number: L19771
Product name: Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging: 25g
Price: $137.65
Updated: 2024/03/01

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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Usage,Production

Chemical Properties

yellow liquid

Uses

analgesic, antipyretic, and anti-inflammatory

Uses

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Suppliers

Americas 1 Belgium 1 Canada 1 China 305 Europe 3 France 2 Germany 7 India 34 Japan 4 Slovakia 1 South Korea 4 Switzerland 2 United Kingdom 14 United States 45 Global 424

Shanghai YuLue Chemical Co., Ltd.

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J & K SCIENTIFIC LTD.

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Alfa Aesar

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TAIYUAN RHF CO.,LTD.

Tel: +86 351 7031519
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TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
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View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers

hebei hongtan Biotechnology Co., Ltd

Product: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price: US $10.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 1000
Release date: 2024-03-22

Hebei Dangtong Import and export Co LTD

Product: Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price: US $50.00-30.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 20Tons
Release date: 2023-10-08

Hebei Chuanghai Biotechnology Co,.LTD

Product: (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER 141942-85-0
Price: US $10.50/KG
Min. Order: 1KG
Purity: 98%
Supply Ability: 10 ton
Release date: 2024-08-21

141942-85-0, Ethyl (R)-(-)-4-cyano-3-hydroxybutyateRelated Search:

4-Ethyl-5-fluoro-6-hydroxypyrimidine Ethyl acetate Methylene dithiocyanate ETHYL 2-CYANOACRYLATE Ethyl formate Ethyl butyrate Ethyl cyanoformate Ethanol Ethyl 3-hydroxybutyrate Ethyl isobutyrate 2,3,4-Trihydroxybenzoic acid Sodium cyanoborohydride Ethylparaben 2-Ethoxyethanol ISOXADIFEN-ETHYL Trinexapac-ethyl HATU (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate

(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER

(R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER

(R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE

(R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE

(S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL

ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE

ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE

ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE

ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE

ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE

BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)

BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)

thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate

(3R)-4-cyano-3-hydroxybutyric acid ethyl ester

FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate

Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester

Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]

ethyle(R)-4-cyano-3-hydroxybutanoate

ATS-5

(R)-4-Cyano-3-hydroxy butanoate

(R)-4-cyano-3-hydroxybutyric

R(-)-4-cyano-3-hydroxybutyrtc ethyl ester

ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE

R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER

R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5

R(-)-4-Cyano-3-hydroxubutyricethylester

(R)-4-Cyano-3-hydroxybuttersureethylester

(R)-4-cyano-3-hydrobutyric acid ethyl ester

(R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL

RETINCIC ACID

[R]-[-]-Ethyl-cyano-3-hydroxybutyrate

(R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester

Ethyl (R)-4-cyano-3-hydroxybutanoate,99%

Ethyl (R)-4-cyano-3-hydroxybutanoate,95%

Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester

Ethyl (R)-(-)-4-cyan

4-Cyano-3-hydroxy-butyric acid ethyl ester

)-4-cyano-3-hydroxybutyrate

Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1)

(R)-Ethyl 4-cyano-3-

Ats-5(For Atorvastatin)

Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate &gt

(R)-(-)-4-Cyano-3-hydroxybutyrate

Atorvastatin Impurity 127

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl

(R)-(-)-4-CYANO-3-HYDROXYBUTYATE

(3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester

Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5)

Atorvastatin calcium impurity 63

ethyl (R)-3-hydroxy-4-cyano-butyrate

Atorvastatin Impurity 166

141942-85-0

41942-85-0

NCCH2CHOHCH2CO2C2H5