ChemicalBook > CAS DataBase List > Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Product Name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
CAS No.
141942-85-0
Chemical Name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms
ATS-5;RETINCIC ACID;Ethyl (R)-(−Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric;(R)-4-Cyano-3-hydroxy butanoate
CBNumber
CB5188978
Molecular Formula
C7H11NO3
Formula Weight
157.17
MOL File
141942-85-0.mol
More
Less

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Property

alpha 
-5 º (neat)
Boiling point:
270 °C(lit.)
Density 
1.114 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.448(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
pka
13.03±0.20(Predicted)
form 
Liquid
Specific Gravity
1.114
color 
Colorless to yellow
optical activity
[α]25/D 5°, neat
BRN 
5328715
InChIKey
LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference
141942-85-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
HS Code 
29269090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P501Dispose of contents/container to..…

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
479772
Product name
Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate
Purity
95%
Packaging
5g
Price
$54.9
Updated
2021/12/16
TCI Chemical
Product number
C1474
Product name
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity
>97.0%(GC)
Packaging
1g
Price
$17
Updated
2021/12/16
TCI Chemical
Product number
C1474
Product name
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity
>97.0%(GC)
Packaging
5g
Price
$47
Updated
2021/12/16
Alfa Aesar
Product number
L19771
Product name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging
5g
Price
$42.6
Updated
2021/12/16
Alfa Aesar
Product number
L19771
Product name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging
25g
Price
$136
Updated
2021/12/16
More
Less

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Usage,Production

Chemical Properties

yellow liquid

Uses

Atorvastatin Intermediate

Uses

analgesic, antipyretic, and anti-inflammatory

Uses

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Suppliers

Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187-
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10081
Advantage
55
Xinxiang City Oran Biotechnology Co. Ltd.
Tel
0373-6766851-
Fax
0373-6766851
Email
alchemic516@163.com
Country
China
ProdList
52
Advantage
58
Shanghai Tuolei Chemical Reagents Co., Ltd.
Tel
86-021-50318510; 13817154396;QQ:93992035
Fax
021-58650104
Email
tuolei@tlrealm.com
Country
China
ProdList
69
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
+86-021-61259100
Fax
86-21-61259102
Email
int02@meryer.com
Country
China
ProdList
40264
Advantage
62
INTATRADE GmbH
Tel
+49 3493/605464
Fax
+49 3493/605470
Email
sales@intatrade.de
Country
Germany
ProdList
3579
Advantage
66
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD
Tel
570-6040289-
Fax
+86-570-6259526
Email
sales@afmpharm.com;
Country
China
ProdList
96
Advantage
61
Alfa Aesar
Tel
400-610-6006; 021-67582000
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30159
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2346
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386 / 800-988-0390
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24555
Advantage
81
More
Less

View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers

Hebei Minshang Biotechnology Co.,Ltd
Product
Ethyl (3R)-4-cyano-3-hydroxybutanoate 141942-85-0
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
500ton/month
Release date
2018-09-19
Hebei Crovell Biotech Co Ltd
Product
(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER 141942-85-0
Price
US $10.50/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2021-07-01
Zhuozhou Wenxi import and Export Co., Ltd
Product
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0] 141942-85-0
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27

141942-85-0, Ethyl (R)-(-)-4-cyano-3-hydroxybutyateRelated Search:


  • (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
  • (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
  • (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE
  • ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
  • ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
  • ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE
  • BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)
  • BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)
  • thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate
  • (3R)-4-cyano-3-hydroxybutyric acid ethyl ester
  • FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate
  • Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
  • ethyle(R)-4-cyano-3-hydroxybutanoate
  • ATS-5
  • (R)-4-Cyano-3-hydroxy butanoate
  • (R)-4-cyano-3-hydroxybutyric
  • R(-)-4-cyano-3-hydroxybutyrtc ethyl ester
  • ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE
  • R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER
  • R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5
  • R(-)-4-Cyano-3-hydroxubutyricethylester
  • (R)-4-Cyano-3-hydroxybuttersureethylester
  • (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • RETINCIC ACID
  • [R]-[-]-Ethyl-cyano-3-hydroxybutyrate
  • (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,99%
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,95%
  • Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyan
  • 4-Cyano-3-hydroxy-butyric acid ethyl ester
  • )-4-cyano-3-hydroxybutyrate
  • Ethyl (R)-(&#8722
  • Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1)
  • (R)-Ethyl 4-cyano-3-
  • Ats-5(For Atorvastatin)
  • Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate &gt
  • (R)-(-)-4-Cyano-3-hydroxybutyrate
  • Atorvastatin Impurity 127
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyate fandachem
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl
  • (R)-(-)-4-CYANO-3-HYDROXYBUTYATE
  • 141942-85-0
  • 41942-85-0
  • NCCH2CHOHCH2CO2C2H5
  • Organic Building Blocks
  • Esters
  • Chiral Building Blocks