ChemicalBook > CAS DataBase List > Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Product Name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
CAS No.
141942-85-0
Chemical Name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms
ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric
CBNumber
CB5188978
Molecular Formula
C7H11NO3
Formula Weight
157.17
MOL File
141942-85-0.mol
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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Property

alpha 
-5 º (neat)
Boiling point:
270 °C(lit.)
Density 
1.114 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.448(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka
13.03±0.20(Predicted)
form 
Liquid
Specific Gravity
1.114
color 
Colorless to yellow
optical activity
[α]25/D 5°, neat
BRN 
5328715
InChIKey
LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference
141942-85-0(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
HS Code 
29269090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
479772
Product name
Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate
Purity
95%
Packaging
5g
Price
$87.2
Updated
2023/06/20
TCI Chemical
Product number
C1474
Product name
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity
>97.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
C1474
Product name
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity
>97.0%(GC)
Packaging
5g
Price
$35
Updated
2024/03/01
Alfa Aesar
Product number
L19771
Product name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging
5g
Price
$43.65
Updated
2024/03/01
Alfa Aesar
Product number
L19771
Product name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging
25g
Price
$137.65
Updated
2024/03/01
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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Usage,Production

Chemical Properties

yellow liquid

Uses

analgesic, antipyretic, and anti-inflammatory

Uses

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials

Preparation Products

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Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Suppliers

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View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers

Hebei Dangtong Import and export Co LTD
Product
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price
US $50.00-30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-08
hebei hongtan Biotechnology Co., Ltd
Product
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-22
Hebei Mojin Biotechnology Co., Ltd
Product
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price
US $0.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
50000KG/month
Release date
2024-01-12

141942-85-0, Ethyl (R)-(-)-4-cyano-3-hydroxybutyateRelated Search:

4-Ethyl-5-fluoro-6-hydroxypyrimidine Ethyl acetate Methylene dithiocyanate ETHYL 2-CYANOACRYLATE Ethyl formate Ethyl butyrate Ethyl cyanoformate Ethanol Ethyl 3-hydroxybutyrate Ethyl isobutyrate 2,3,4-Trihydroxybenzoic acid Sodium cyanoborohydride Ethylparaben 2-Ethoxyethanol ISOXADIFEN-ETHYL Trinexapac-ethyl HATU (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate

  • (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
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  • ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE
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  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
  • ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE
  • BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)
  • BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)
  • thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate
  • (3R)-4-cyano-3-hydroxybutyric acid ethyl ester
  • FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate
  • Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
  • ethyle(R)-4-cyano-3-hydroxybutanoate
  • ATS-5
  • (R)-4-Cyano-3-hydroxy butanoate
  • (R)-4-cyano-3-hydroxybutyric
  • R(-)-4-cyano-3-hydroxybutyrtc ethyl ester
  • ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE
  • R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER
  • R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5
  • R(-)-4-Cyano-3-hydroxubutyricethylester
  • (R)-4-Cyano-3-hydroxybuttersureethylester
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  • (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • RETINCIC ACID
  • [R]-[-]-Ethyl-cyano-3-hydroxybutyrate
  • (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,99%
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,95%
  • Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester
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  • (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5)
  • Atorvastatin calcium impurity 63
  • Atorvastatin Impurity 166
  • ethyl (R)-3-hydroxy-4-cyano-butyrate
  • 141942-85-0
  • 41942-85-0
  • NCCH2CHOHCH2CO2C2H5