ChemicalBook > CAS DataBase List > Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate

Product Name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
CAS No.
141942-85-0
Chemical Name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
Synonyms
ATS-5;ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE;RETINCIC ACID;Ethyl (R)-(-)-4-cyan;(R)-Ethyl 4-cyano-3-;Ats-5(For Atorvastatin);Atorvastatin Impurity 127;Atorvastatin Impurity 166;)-4-cyano-3-hydroxybutyrate;(R)-4-cyano-3-hydroxybutyric
CBNumber
CB5188978
Molecular Formula
C7H11NO3
Formula Weight
157.17
MOL File
141942-85-0.mol
More
Less

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Property

alpha 
-5 º (neat)
Boiling point:
270 °C(lit.)
Density 
1.114 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.448(lit.)
Flash point:
>230 °F
storage temp. 
2-8°C
solubility 
Chloroform (Sparingly), DMSO (Slightly), Methanol (Slightly)
pka
13.03±0.20(Predicted)
form 
Liquid
Specific Gravity
1.114
color 
Colorless to yellow
optical activity
[α]25/D 5°, neat
BRN 
5328715
InChIKey
LOQFROBMBSKWQY-ZCFIWIBFSA-N
CAS DataBase Reference
141942-85-0(CAS DataBase Reference)
More
Less

Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
1
HS Code 
29269090
More
Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P337+P313IF eye irritation persists: Get medical advice/attention.

More
Less

N-Bromosuccinimide Price

Sigma-Aldrich
Product number
479772
Product name
Ethyl (R)-(?)-4-cyano-3-hydroxybutyrate
Purity
95%
Packaging
5g
Price
$87.2
Updated
2023/06/20
TCI Chemical
Product number
C1474
Product name
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity
>97.0%(GC)
Packaging
1g
Price
$16
Updated
2024/03/01
TCI Chemical
Product number
C1474
Product name
Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate
Purity
>97.0%(GC)
Packaging
5g
Price
$35
Updated
2024/03/01
Alfa Aesar
Product number
L19771
Product name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging
5g
Price
$43.65
Updated
2024/03/01
Alfa Aesar
Product number
L19771
Product name
Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate, 98%
Packaging
25g
Price
$137.65
Updated
2024/03/01
More
Less

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Chemical Properties,Usage,Production

Chemical Properties

yellow liquid

Uses

analgesic, antipyretic, and anti-inflammatory

Uses

(3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester is used in a biocatalytic process for the synthesis of an atorvastatin intermediate and degredation products/impurities.

Application

Hydroxyglutaryl coenzyme A (HMG-CoA) reductase inhibitors are a new class of lipid-lowering drugs, and they have a market share of more than 10 billion US dollars in the current pharmaceutical field. They can selectively inhibit the rate-limiting enzyme HMG-CoA reductase in cholesterol synthesis in the liver, reduce liver lipoprotein production, and increase the expression of low-density lipoprotein (LDL) cholesterol receptors, thereby reducing plasma cholesterol levels. They can also significantly reduce very low-density lipoprotein (VLDL) and triglycerides, and increase anti-atherosclerotic high-density protein (HDL), preventing atherosclerosis and coronary heart disease.
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate is an important intermediate for the synthesis of HMG-CoA reductase inhibitors. If it is used as a raw material, synthetic atorvastatin is mainly used for the treatment of hypercholesterolemia and mixed hyperlipidemia, coronary heart disease and stroke.

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Ethyl (R)-(-)-4-cyano-3-hydroxybutyate Suppliers

Americas 1 Belgium 1 Canada 1 China 305 Europe 3 France 2 Germany 7 India 34 Japan 4 Slovakia 1 South Korea 4 Switzerland 2 United Kingdom 14 United States 45 Global 424
Shanghai YuLue Chemical Co., Ltd.
Tel
021-60345187 13671753212
Fax
021-34702061
Email
lzz841106@aliyun.com
Country
China
ProdList
10276
Advantage
55
Jiangsu WNC Pharmaceutical Co.,Ltd
Tel
13951385330
Email
25541157@qq.com
Country
China
ProdList
19
Advantage
58
Shanghai Tuolei Chemical Reagents Co., Ltd.
Tel
86-021-50318510
Fax
021-58650104
Country
China
ProdList
69
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833 400-666-7788
Fax
86-10-82849933
Email
jkinfo@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Meryer (Shanghai) Chemical Technology Co., Ltd.
Tel
021-61259108 18621169109
Fax
86-21-61259102
Email
market03@meryer.com
Country
China
ProdList
40228
Advantage
62
JIANGXI AIFEIMU TECHNOLOGY CO.,LTD
Tel
793-33899567 13735087952
Fax
+86-570-6259526
Email
sales@afmpharm.com
Country
China
ProdList
91
Advantage
61
Alfa Aesar
Tel
400-6106006
Fax
021-67582001/03/05
Email
saleschina@alfa-asia.com
Country
China
ProdList
30123
Advantage
84
TAIYUAN RHF CO.,LTD.
Tel
+86 351 7031519
Fax
+86 351 7031519
Email
sales@RHFChem.com
Country
China
ProdList
2338
Advantage
56
TCI (Shanghai) Development Co., Ltd.
Tel
021-67121386
Fax
021-67121385
Email
Sales-CN@TCIchemicals.com
Country
China
ProdList
24529
Advantage
81
Energy Chemical
Tel
021-021-58432009 400-005-6266
Fax
021-58436166
Email
sales8178@energy-chemical.com
Country
China
ProdList
44688
Advantage
61
Capot Chemical Co., Ltd
Tel
+86 (0) 571 85 58 67 18
Fax
0086-571-85864795
Email
sales@capotchem.com
Country
China
ProdList
18207
Advantage
66
Beijing Ouhe Technology Co., Ltd
Tel
010-82967028 13552068683
Fax
+86-10-82967029
Email
2355560935@qq.com
Country
China
ProdList
12390
Advantage
60
JinYan Chemicals(ShangHai) Co.,Ltd.
Tel
13817811078
Fax
86-021-50426522,50426273
Email
sales@jingyan-chemical.com
Country
China
ProdList
9976
Advantage
60
Jia Xing Isenchem Co.,Ltd
Tel
0573-85285100 18627885956
Fax
0573-85285100
Email
isenchem@163.com
Country
China
ProdList
9499
Advantage
66
Adamas Reagent, Ltd.
Tel
400-6009262 16621234537
Fax
021-64823266
Email
chenyj@titansci.com
Country
China
ProdList
14103
Advantage
59
Accela ChemBio Co.,Ltd.
Tel
021-50795510 4000665055
Fax
021-50795055
Email
sales@accelachem.com
Country
China
ProdList
11655
Advantage
64
Shanghai Longsheng chemical Co.,Ltd.
Tel
021-58099652-8005 13585536065
Fax
021-58099609
Email
bin.wu@shlschem.com
Country
China
ProdList
9809
Advantage
59
Shanghai Hanhong Scientific Co.,Ltd.
Tel
021-54306202 13764082696
Email
info@hanhongsci.com
Country
China
ProdList
42958
Advantage
64
Chemsky（shanghai）International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32321
Advantage
50
XiaoGan ShenYuan ChemPharm co,ltd
Tel
15527768850
Email
1791901229@qq.com
Country
China
ProdList
8838
Advantage
52
Syntechem Co.,Ltd
Tel
Fax
E-Mail Inquiry
Email
info@syntechem.com
Country
China
ProdList
12984
Advantage
57
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11707
Advantage
57
Tianjin heowns Biochemical Technology Co., Ltd.
Tel
400 638 7771
Email
sales@heowns.com
Country
China
ProdList
14435
Advantage
57
Hunan Hui Bai Shi Biotechnology Co., Ltd.
Tel
0731-85526065 13308475853
Email
ivy@hnhbsj.com
Country
China
ProdList
4552
Advantage
62
Nanjing Vital Chemical Co., Ltd.
Tel
Please Send Email 18652950785
Fax
025-87193546
Email
chemweiao@163.com
Country
China
ProdList
4378
Advantage
65
Aemon Chemical
Tel
0086-755-86198205
Email
acinfo@aemonchem.com
Country
China
ProdList
1931
Advantage
57
Hangzhou Yuhao Chemical Technology Co., Ltd
Tel
0571-82693216
Fax
+86-571-82880190
Email
info@yuhaochemical.com
Country
China
ProdList
9387
Advantage
52
Shanghai Sphchem Co., Ltd.
Tel
21-21-56491756 13512199871
Fax
021-5649-1756
Email
sales@panhongchem.com
Country
China
ProdList
4000
Advantage
55
Wuhan Fortuna Chemical Co., Ltd
Tel
027-59207852 13308628970
Fax
QQ3130921841
Email
buy@fortunachem.com
Country
China
ProdList
2871
Advantage
58
Thermo Fisher Scientific
Tel
800-810-5118
Fax
+86-10-84193589
Email
cnchemical@thermofisher.com
Country
China
ProdList
17770
Advantage
75
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-010-52878169 15801002657
Email
sales@bjcomparison.com
Country
China
ProdList
4990
Advantage
58
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280 17798518460
Fax
(1)02557626880
Email
cfzhang@aikonchem.com
Country
China
ProdList
19915
Advantage
55
9ding chemical ( Shanghai) Limited
Tel
4009209199
Fax
86-021-52271987
Email
sales@9dingchem.com
Country
China
ProdList
22514
Advantage
55
Shanghai Aladdin Bio-Chem Technology Co.,LTD
Tel
400-400-6206333 18521732826
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
25003
Advantage
65
The future of Shanghai Industrial Co., Ltd.
Tel
021-61552785
Fax
021-55660885
Email
sales@shshiji.com
Country
China
ProdList
9545
Advantage
55
Cantotech Chemicals, Ltd.
Tel
86-0755-86635001
Fax
86-0755-22642228
Email
cantotech@126.com
Country
China
ProdList
4566
Advantage
55
Shanghai Raise Chemical Technology Co.,Ltd
Tel
+86-021-50935922
Fax
+86-021-33847795
Country
China
ProdList
7865
Advantage
55
Guangzhou Isun Pharmaceutical Co., Ltd
Tel
020-39119399 18927568969
Fax
020-39119999
Email
isunpharm@qq.com
Country
China
ProdList
4428
Advantage
55
TargetMol Chemicals Inc.
Tel
021-021-33632979 15002134094
Fax
021-33632979
Email
marketing@targetmol.com
Country
China
ProdList
7783
Advantage
58
Beijing Universal Century Technology Co., Ltd.
Tel
400-8706899
Fax
400-8706899
Email
hysj_bj.com
Country
China
ProdList
3583
Advantage
55
Hubei XinyuanShun Chemical Co., Ltd.
Tel
13971561712, 13995564702, 027-50664929
Fax
027-50664927
Email
hbeixys2001@163.com
Country
China
ProdList
3120
Advantage
55
Shanghai JONLN Reagent Co., Ltd.
Tel
400-0066400 13621662912
Fax
021-55660885
Email
422131432@qq.com
Country
China
ProdList
9978
Advantage
55
Bide Pharmatech Ltd.
Tel
400-164-7117 13681763483
Fax
+86-21-61629029
Email
product02@bidepharm.com
Country
China
ProdList
41462
Advantage
60
Chemwill Asia Co.,Ltd.
Tel
86-21-51086038
Fax
86-21-51861608
Country
China
ProdList
2930
Advantage
58
Shanghai DiBai Chemicals Co., Ltd.
Tel
021-54359730 400-008-9730
Fax
021-54353864
Email
info@chemxyz.com
Country
China
ProdList
3991
Advantage
60
Wuhan Dahua Pharmaceutical Co., Ltd.
Tel
027-59262863 13277907145 3091977954
Fax
027-59420980
Country
China
ProdList
4943
Advantage
58
Hangzhou XunDa Bio-Technology Co., Ltd.
Tel
0571-86932585
Fax
0571-86932585
Email
xuandasales@163.com
Country
China
ProdList
41
Advantage
58
SHANGHAI BANGCHENG CHEMICAL Co.,Ltd.
Tel
021-69106960 13701823733
Fax
021-69106780
Email
13701823733@163.com
Country
China
ProdList
4767
Advantage
60
Hangzhou J&H Chemical Co., Ltd.
Tel
0571-+86-571-87396432
Fax
0571-87396431
Email
sales@jhechem.com
Country
China
ProdList
11481
Advantage
59
Wuhan Dahua Weiye Pharmaceutical Chemical Co., Ltd.
Tel
027-59420981,18702770802
Fax
027-83322098
Country
China
ProdList
1975
Advantage
50
More
Less

View Lastest Price from Ethyl (R)-(-)-4-cyano-3-hydroxybutyate manufacturers

hebei hongtan Biotechnology Co., Ltd
Product
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price
US $10.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
1000
Release date
2024-03-22
Hebei Dangtong Import and export Co LTD
Product
Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 141942-85-0
Price
US $50.00-30.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20Tons
Release date
2023-10-08
Hebei Chuanghai Biotechnology Co,.LTD
Product
(R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER 141942-85-0
Price
US $10.50/KG
Min. Order
1KG
Purity
98%
Supply Ability
10 ton
Release date
2024-08-21

141942-85-0, Ethyl (R)-(-)-4-cyano-3-hydroxybutyateRelated Search:

4-Ethyl-5-fluoro-6-hydroxypyrimidine Ethyl acetate Methylene dithiocyanate ETHYL 2-CYANOACRYLATE Ethyl formate Ethyl butyrate Ethyl cyanoformate Ethanol Ethyl 3-hydroxybutyrate Ethyl isobutyrate 2,3,4-Trihydroxybenzoic acid Sodium cyanoborohydride Ethylparaben 2-Ethoxyethanol ISOXADIFEN-ETHYL Trinexapac-ethyl HATU (4R,6R)-tert-Butyl-6-(2-aminoethyl)-2,2-dimethyl-1,3-dioxane-4-acetate

  • (R)-(-)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-4-CYANO-3-HYDROXYBUTYRIC ACID ETHYL ESTER
  • (R)-(-)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
  • (R)-ETHYL 4-CYANO-3-HYDROXYBUTYRATE
  • (S)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • ETHYL (3R)-4-CYANO-3-HYDROXY-BUTANOATE
  • ETHYL (S)-4-CYANO-3-HYDROXYBUTANOATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTANOATE
  • ETHYL-(R)-(+)-4-CYANO-3-HYDROXYBUTANOATE
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyate
  • ETHYL (R)-(-)-4-CYANO-3-HYDROXYBUTYRATE
  • ETHYL (R)-4-CYANO-3-HYDROXYBUTYRATE
  • BUTANOIC ACID, 4-CYANO-3-HYDROXY-, ETHYL ESTER, (R)
  • BUTANOIC ACID 4-CYANO-3-HYDROXY-ETHYL ESTER, (S)
  • thyl (R)-(-)-4-Cyano-3-Hydroxy Butyate
  • (3R)-4-cyano-3-hydroxybutyric acid ethyl ester
  • FEthyl (R)-(-)-4-cyano-3-hydroxybutyrate
  • Atorvastatin interMediates Ats-5 (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • Butanoic acid, 4-cyano-3-hydroxy-, ethyl ester, (3R)-
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate[141942-85-0]
  • ethyle(R)-4-cyano-3-hydroxybutanoate
  • ATS-5
  • (R)-4-Cyano-3-hydroxy butanoate
  • (R)-4-cyano-3-hydroxybutyric
  • R(-)-4-cyano-3-hydroxybutyrtc ethyl ester
  • ATS-5:(R)ETHYL-4-CYANO-3-HYCLROXY BUTANCATE
  • R(-)4-CYANO-3-HYDROXYBUTYRIC ETHYL ESTER
  • R(-)-4-CYANO-3-HYDROXYBUTYRTC ETHYL ESTER /ATS-5
  • R(-)-4-Cyano-3-hydroxubutyricethylester
  • (R)-4-Cyano-3-hydroxybuttersureethylester
  • (R)-4-cyano-3-hydrobutyric acid ethyl ester
  • (R)-4-CYANO-3-HYDROXYBUTANOATE ETHYL
  • RETINCIC ACID
  • [R]-[-]-Ethyl-cyano-3-hydroxybutyrate
  • (R)-(-)-4-Cyano-3-hydroxybutyratic acid, ethyl ester
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,99%
  • Ethyl (R)-4-cyano-3-hydroxybutanoate,95%
  • Atorvastatincalcium(R)-4-cyano-3-hydrobutyric Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyan
  • 4-Cyano-3-hydroxy-butyric acid ethyl ester
  • )-4-cyano-3-hydroxybutyrate
  • Ethyl-(R)-4-(-)-cyano-3-hydroxybutyrate(C-1)
  • (R)-Ethyl 4-cyano-3-
  • Ats-5(For Atorvastatin)
  • Ethyl (R)-(-)-4-Cyano-3-hydroxybutyrate &gt
  • (R)-(-)-4-Cyano-3-hydroxybutyrate
  • Atorvastatin Impurity 127
  • (3R)-4-Cyano-3-hydroxybutanoic Acid Ethyl
  • (R)-(-)-4-CYANO-3-HYDROXYBUTYATE
  • (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl EsterQ: What is (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the CAS Number of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester Q: What is the storage condition of (3R)-4-Cyano-3-hydroxybutyric Acid Ethyl Ester
  • Ethyl (R)-(-)-4-cyano-3-hydroxybutyrate(ATS-5)
  • Atorvastatin calcium impurity 63
  • ethyl (R)-3-hydroxy-4-cyano-butyrate
  • Atorvastatin Impurity 166
  • 141942-85-0
  • 41942-85-0
  • NCCH2CHOHCH2CO2C2H5