4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

Product Name: 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
CAS No.: 438056-69-0
Chemical Name: 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE
Synonyms: Rivaroxaban InterMediate;4-(4-AMinophenyl)-3-Morpholinone;in-3-one;2-Amino-11-picoline;4-(4-aminophenyl)mor;Rivaroxaban Impurity 37;Rivaroxaban intermdiate;Aminophenylmorpholinone;Rivaroxaban Intermediate 1;4-(3-Oxomorpholino)aniline
CBNumber: CB3445660
Molecular Formula: C10H12N2O2
Formula Weight: 192.21
MOL File: 438056-69-0.mol

More

Less

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Property

Melting point:: 171.0 to 175.0 °C
Boiling point:: 502.3±45.0 °C(Predicted)
Density: 1.268
vapor pressure: 0Pa at 25℃
storage temp.: Keep in dark place,Inert atmosphere,Room temperature
solubility: DMSO (Slightly), Methanol (Slightly, Heated)
form: Solid
pka: 4.85±0.10(Predicted)
color: White to Light Brown
Water Solubility: 16.6g/L at 20℃
Major Application: pharmaceutical
InChI: InChI=1S/C10H12N2O2/c11-8-1-3-9(4-2-8)12-5-6-14-7-10(12)13/h1-4H,5-7,11H2
InChIKey: MHCRLDZZHOVFEE-UHFFFAOYSA-N
SMILES: N1(C2=CC=C(N)C=C2)CCOCC1=O
LogP: -0.8 at 25℃
CAS DataBase Reference: 438056-69-0

More

Less

Safety

Safety Statements: 24/25
WGK Germany: WGK 3
HazardClass: IRRITANT
HS Code: 29349990
Storage Class: 11 - Combustible Solids
Hazard Classifications: Aquatic Chronic 3

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

More

Less

N-Bromosuccinimide Price

TCI Chemical

Product number: A2614
Product name: 4-(4-Aminophenyl)morpholin-3-one
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $16
Updated: 2025/07/31

TCI Chemical

Product number: A2614
Product name: 4-(4-Aminophenyl)morpholin-3-one
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $44
Updated: 2025/07/31

TRC

Product number: A625990
Product name: 4-(4-Aminophenyl)-3-morpholinone
Packaging: 250mg
Price: $65
Updated: 2021/12/16

TRC

Product number: A625990
Product name: 4-(4-Aminophenyl)-3-morpholinone
Packaging: 5g
Price: $120
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17817
Product name: 4-(4-Aminophenyl)-3-morpholinone
Packaging: 10g
Price: $130
Updated: 2021/12/16

More

Less

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Chemical Properties,Usage,Production

Chemical Properties

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE is Off-White Solid

Uses

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE is used in the preparation of various Morpholine based pharmaceuticals.

Uses

Rivaroxaban intermediate

Flammability and Explosibility

Non flammable

Synthesis

2-anilinoethanol (11) was condensed with ethyl chloroacetate in the presence of potassium tert-butoxide in tetrahydrofuran to afford the required phenylmorpholinone (12). Nitration of the intermediate morpholinone (12) in a solution of concentrated sulphuric acid with nitric acid below room temperature provided after recrystallization the para-product (13) in > 99.5% HPLC purity. The mother liquor was enriched predominantly with unwanted ortho - and meta-isomers together with depleted para-product. By subsequent hydrogenation of the nitro group in 13 with palladium on charcoal in methanol the 4-(4-Aminophenyl)morpholin-3-one (14) was obtained.

[1] W. MEDERSKI; Markus W; P Wendel. Practical and efficient processes for the preparation of 4-(4-aminophenyl)morpholin-3-ones on a larger scale: precursor of factor Xa inhibitors[J]. Heterocycles, 2007, 74 1: 437-445. DOI:10.3987/COM-07-S(W)22.

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Preparation Products And Raw materials

Raw materials

Sodium hydride Monoethanolamine 4-Fluoronitrobenzene Acetonitrile Benzyltriethylammonium chloride 2-(2-Chloroethoxy)ethanol Acetone Toluene Potassium carbonate Chromium(VI) oxide Triethylamine Palladium Stannous chloride 1,4-Dioxane Dichloromethane Thionyl chloride Sulfuric acid 4-Nitroaniline Ethyl chloroacetate

Preparation Products

More

Less

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE Suppliers

Americas 1 Canada 1 China 530 China Hong Kong 1 Czech Republic 2 Europe 1 India 111 Japan 2 Spain 2 Switzerland 1 United Kingdom 3 United States 26 Global 681

Bayee Biotech (Anqing) Co., Ltd.

Tel: 0556-5032306 18917961636
Email: wtx@bayeebio.com
Country: China
ProdList: 229
Advantage: 61

EASON Chemical Co., LIMITED

Tel: 0576-0576-89232655 13566878689
Fax: 0576-88860891
Email: info@seasonsbio.com
Country: China
ProdList: 37
Advantage: 58

Jilin Lianben Technology Development Co., Ltd

Tel: 0432-62601618 13756693631
Fax: 0432-62601618
Email: wangjiaqi@lianben.com
Country: China
ProdList: 46
Advantage: 58

Jinan Dexinjia Bio&Tech Co., Ltd

Tel: 053182375892 15098789112
Fax: 0531-82375893
Email: haiyao@jndxj.com
Country: China
ProdList: 1634
Advantage: 58

Henan Dongyao Pharmaceutical Technology Co., Ltd

Tel: 18519331287; 18519331287
Email: 1751713684@qq.com
Country: China
ProdList: 224
Advantage: 58

Hangzhou Bright Pharma Biotechnology Co., Ltd.

Tel: 0571-85775770 13575490453
Email: info@brightpharmabio.com
Country: China
ProdList: 33
Advantage: 58

DoEasy Pharma Co., Ltd.

Tel: 0571-0571-28806358 15397199029
Fax: 0571-89057225
Email: songxy@doepharma.com
Country: China
ProdList: 88
Advantage: 55

J & K SCIENTIFIC LTD.

Tel: 18210857532; 18210857532
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 96815
Advantage: 76

Chembest Research Laboratories Limited

Tel: +86-21-20908456
Fax: 021-58180499
Email: sales@BioChemBest.com
Country: China
ProdList: 6003
Advantage: 61

TCI (Shanghai) Development Co., Ltd.

Tel: 021-67121386
Fax: 021-67121385
Email: Sales-CN@TCIchemicals.com
Country: China
ProdList: 24529
Advantage: 81

More

Less

View Lastest Price from 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE manufacturers

Handan City Zechi trading Co., LTD

Product: 4-(4-aMinophenyl)Morpholin-3-one 438056-69-0
Price: US $1.00/g
Min. Order: 100g
Purity: 99
Supply Ability: 1000
Release date: 2025-08-11

Hebei Chuanghai Biotechnology Co., Ltd

Product: 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 438056-69-0
Price: US $10.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: 10 mt
Release date: 2024-11-21

Hebei Dangtong Import and export Co LTD

Product: 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 438056-69-0
Price: US $180.00-140.00/kilograms
Min. Order: 100kilograms
Purity: 99%
Supply Ability: 100tons
Release date: 2023-03-01

438056-69-0, 4-(4-AMINOPHENYL)MORPHOLIN-3-ONERelated Search:

4-(4-NITROPHENYL)MORPHOLIN-3-ONE Rivaroxaban Impurity 43 Rivaroxaban Impurity 34 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- POLYSTYRENE IODOSOACETATE 1,2-Cyclohexanedione 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid 2-[(2R)-2-Hydroxy-3-[[4-(3-oxo-4-Morpho linyl)phenyl]aMino]propyl]-1H-isoindole-1 ,3(2H)-dione Rivaroxaban (S)-(+)-Glycidyl Phthalimide 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Rivaroxaban iMpurity 5 (S)-(+)-Epichlorohydrin

Rivaroxaban Intermediate 1

Rivaroxaban InterMediate

4-(4-aMinophenyl) Morpholinone

3-Morpholinone, 4-(4-aminophenyl)-

4-(4-Aminophenyl)morpholin-3-one ,97%

4-(4-AMinophenyl)-3-Morpholinone

4-(3-Oxo-4-Morpholinyl)aniline

4-(3-Oxo-4-Morpholinyl)aniline-d4

4-(4-AMinophenyl)Morpholin-3-one(For Rivaroxaban)

4-(4-AMinophenyl)Morpholin-3-1

4-(4-aminophenyl)morphin-3-one

4-(4-aMinophenyl)Morpholine-3- ketone

4-(4-AMinophlenyl)Morpholin-3-one

Rivaroxaban Impurity 37

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE

4-(-4-amino phenyl0-3-Morpholine

4-(4-AMINO PHENYL)MORPHOLINE-3-ONE

4-(4-Aminophenyl)-2,2,5,5,6,6-d6-morphoIin-3-one

Rivaroxaban intermdiate

4-(4-Aminophenyl)morpholin-3-one &gt

in-3-one

Rivaroxaban Aminophenyl Impurity

4-(4-Aminophenyl)-3-Morpholine

4-(3-Oxomorpholino)aniline

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 438056-69-0

4-(4-AMINOPENYL)MORPHOLIN-3-ONE

4-(4-AMINOPHENYL)MORPHOLIN-3-ONE ISO 9001：2015 REACH

Rivaroxaban intermediates，4-(4-aminophenyl)morpholin-3-one

4-(4-Aminophenyl)morpholin-2-one

4-(4-Aminophenyl)morpholin-3-one (Rivaroxaban Intermediate)

Rivaroxaban Impurity-1/4-(4-Aminophenyl)-3-morpholinone

2-Amino-11-picoline

4-(4-aminophenyl)mor

4-(4-AMINOPHENYL)MORPHOLIN-3-ON

4-(4-Aminophenyl)morphilin-3-one

4-(4-aminophenyl)- 3-morpholinon

(4-Aminophenyl)Morpholin-3-one

Aminophenylmorpholinone

4-(4-Aminophernyljmorpholin-3-one

438056-69-0

43805-69-0

Amines and Anilines

Heterocycles

Amines

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals

Intermediates

Intermediate of Rivaroxaban