1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-

Uses

Product Name: 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-
CAS No.: 446292-08-6
Chemical Name: 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-
Synonyms: (S)-2-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)isoindoline-1,3-dione;Rivaroxaban-5;C22HjgNzO6;Rivaroxaban G;Rivaroxaban ImpVI;2-Amino-13-picoline;RIVAROXABAN EP IMP G;Rivaroxaban Intermediate5;Rivaroxaban EP Impurity G;Rivaroxaban Impurities365
CBNumber: CB92468058
Molecular Formula: C22H19N3O6
Formula Weight: 421.4
MOL File: 446292-08-6.mol

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1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Property

Melting point:: 213-215°C
Boiling point:: 702.9±55.0 °C(Predicted)
Density: 1.465±0.06 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: Chloroform (Slightly), DMSO (Slightly), Methanol (Slightly)
pka: 0.99±0.20(Predicted)
form: Solid
color: White to Off-White
Water Solubility: 12mg/L at 20℃
InChI: InChI=1S/C22H19N3O6/c26-19-13-30-10-9-23(19)14-5-7-15(8-6-14)24-11-16(31-22(24)29)12-25-20(27)17-3-1-2-4-18(17)21(25)28/h1-8,16H,9-13H2/t16-/m1/s1
InChIKey: KUQNYAUTIWQAKY-MRXNPFEDSA-N
SMILES: C1(=O)C2=C(C=CC=C2)C(=O)N1C[C@@H]1OC(=O)N(C2=CC=C(N3CCOCC3=O)C=C2)C1
LogP: -0.2 at 25℃

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P385850
Product name: 4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
Packaging: 25mg
Price: $120
Updated: 2021/12/16

TRC

Product number: P385850
Product name: 4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
Packaging: 50mg
Price: $155
Updated: 2021/12/16

TRC

Product number: P385850
Product name: 4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone
Packaging: 100mg
Price: $185
Updated: 2021/12/16

AK Scientific

Product number: Z6156
Product name: 1H-Isoindole-1,3(2H)-dione,2-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-
Packaging: 1g
Price: $143
Updated: 2021/12/16

Matrix Scientific

Product number: 092112
Product name: (S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)-oxazolidin-5-yl)methyl)isoindoline-1,3-dione
Purity: 95+%
Packaging: 250mg
Price: $439
Updated: 2021/12/16

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1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Chemical Properties,Usage,Production

Uses

1H-isoindole-1,3(2H)-dione, 2-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]- is an important intermediate for the synthesis of rivaroxaban, which is an anticoagulant and the first orally active direct factor Xa inhibitor.

Chemical Properties

White Solid

Uses

Rivaroxaban intermediate.

Flammability and Explosibility

Non flammable

Synthesis

1325210-64-7

161596-47-0

446292-08-6

The general procedure for the synthesis of 2-[[(5S)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione from 4-(3-oxomorpholinyl)phenyl isocyanate and (S)-2-(ethoxylen-2-ylmethyl)isoindoline-1,3-dione was as follows: the (S)- 2-(oxiran-2-ylmethyl)isoindoline-1,3-dione (4.56 g, 22.46 mmol, 1.3 eq.) and 4-(4-isocyanatophenyl)morpholin-3-one (3.77 g, 17.29 mmol) were dissolved in isoamyl acetate (70 mL), respectively. The reaction mixture was heated to 120 °C, followed by the addition of magnesium chloride (0.12 g, 1.28 mmol). After the reaction lasted for 4 h, a white solid product (6.97 g, 95.5% yield) was obtained by filtration. The product was confirmed by mass spectrometry by ESI-MS (m/z): 422 (M + H), 444 (M + Na); 1H NMR (400 MHz, CDCl3) δ: 3.74 (m, 2H), 3.94 (m, 4H), 4.10 (m, 2H), 4.32 (s, 2H), 4.98 (m, 1H), 7.34 (d, 2H), and 7.56 (d, 2H), 7.75 (m, 2H), 7.88 (m, 2H) were characterized by NMR; HPLC purity was 98.82%.

References

[1] Patent: EP2837628, 2015, A1. Location in patent: Paragraph 0029
[2] Patent: US2015/38704, 2015, A1. Location in patent: Paragraph 0048-0051

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Preparation Products And Raw materials

Raw materials

Preparation Products

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1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Suppliers

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View Lastest Price from 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- manufacturers

Henan Aochuang Chemical Co.,Ltd.

Product: (R)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione 446292-08-6
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 98%
Supply Ability: 1Ton
Release date: 2022-09-19

Changzhou Rokechem Technology Co., Ltd.

Product: 2-[[(5S)-2-Oxo-3-[4-(3-oxo-4- morpholinyl)phenyl]-5- oxazolidinyl]methyl]-1H-isoindole- 1,3(2H)-dione 446292-08-6
Price: US $0.00-0.00/Kg
Min. Order: 1Kg
Purity: 99%
Supply Ability: 1-10000kgs
Release date: 2023-05-25

Xinxiang Hongqi District Houyuan Trading Co.,Ltd

Product: 1H-ISOindole-1,3(2H) -Dione, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHolinyl)PHENYL] -5-OXAZolidinyl]METHYL]- 446292-08-6
Price: US $30.00-28.00/Kg
Min. Order: 1Kg
Purity: 99.0% up
Supply Ability: 50 tons per month
Release date: 2022-10-06

446292-08-6, 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-Related Search:

Rivaroxaban Metabolite 8 AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-ThiophenecarboxaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 5-R-Rivaroxaban Rivaroxaban POLYSTYRENE IODOSOACETATE 1,2-Cyclohexanedione 4-(4-NITROPHENYL)MORPHOLIN-3-ONE (S)-(+)-Glycidyl Phthalimide 4-[4-(N-(3-chloro-(2R)-2-hydroxy-1-propyl)aMino)phenyl]Morpholin-3-one (S)-4-(4-(5-(Aminomethyl)-2-oxooxazolidin-3-yl)phenyl)morpholin-3-one.HCl 5-CHLOROTHIOPHENE-2-CARBONYL CHLORIDE Ethyl (R)-(-)-4-cyano-3-hydroxybutyate 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- 4-(4-AMINOPHENYL)MORPHOLIN-3-ONE 5-Chloro-2-thiophenecarboxylic Acid m-(Trifluoromethyl)phenylacetic acid (S)-(+)-Epichlorohydrin

1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-

(S)-2-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)isoindoline-1,3-dione

2-({(5S)-2-oxo-3-[4-(3-oxoMorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}Methyl)-1H-isoindole-1,3(2H)-dione

RivaroxabanInterMediates-01

4-[4-[(5S)-5-PhthaliMidoMethyl-2-oxo-3-oxazolidinyl]phenyl]-3-Morpholinone

2-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione

Rivaroxaban Intermediate5

Rivaroxaban Phthalimido Impurity

2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}

2 - [[(5S) -2- oxo-3- [4- (3-oxo - (morpholin-4-yl)) phenyl] -5-oxazolidinyl] methyl] lH- isoindole -1,3 (2H) - dione

2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-

(R)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione

Rivaroxaban ImpVI

Rivaroxaban impurity 4/2-[[(5S)-2-Oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-1H-isoindole-1,3(2H)-dione

2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl}methyl)-1H-isoindole-1,3(2H)-dion

Rivaroxaban-5

Rivaroxaban G

(S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione (Rivaroxaban)

Rivaroxaban EP Impurity G

2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-1H-ISOINDOLE-1,3(2H)-DIONE CAS: 446292-08-6

Rivaroxaban PTH Imp/Rivaroxaban EP Impurity G

2-Amino-13-picoline

2-({(5S)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazoli...

Rivaroxaban Impurities365

Rivaroxaban EP Impurity GQ: What is Rivaroxaban EP Impurity G Q: What is the CAS Number of Rivaroxaban EP Impurity G Q: What is the storage condition of Rivaroxaban EP Impurity G Q: What are the applications of Rivaroxaban EP Impurity G

TIANFUCHEM--446292-08-6---1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]-

(S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazoli

4-[4-[(5S)-5-Phthalimidomethyl-2-oxo-3-oxazolidinyl]phenyl]-3-morpholinone (or) 1H-isoindole-1,3 (2H)-Dione, 2-[[(5S)-2-Oxo-3-[4-(3-Oxo-4Morpholinyl)Phenyl]-5-Oxazolidinyl]methyl

2-[[(5S)-2-Oxo-3-[4-(3-oxo -4-morpholinyl)phenyl]-5-o xazolidinyl]methyl]-1H-isoi ndole-1,3(2H)

C22HjgNzO6

2- [(5S) -2-oxo-3- [4- (3-oxo-4-morphinyl) phenyl] -5-oxazolyl] methyl] -1H-isoindole-1,3 (2H) - dione

Intermediate of Rivaroxaban 3

RIVAROXABAN EP IMP G

2- [[(5S) -2-oxo-3- [4- (3-oxo-4-morpholinyl) phenyl] -5-oxazolinyl] methyl] -1H-isoindole-1,3 (2H) - dione

Rivaroxaban Intermediates II

(S)-2-{2-Oxo-3-[4-(3-oxo-morpholin-4-yl)-phenyl]-oxazolidin-5-ylmethyl}-isoindole-1,3-dione

2-1 (5S) -2-oxo-3- [4 (3-oxo-4-morpholinyl) phenyl} -5-imidazolidinyl] methyl] -1H isoindole-1,3 (2H) - dione

Rivaroxaban EP Impurity G (Rivaroxaban USP Related Compound G)

2-[[(5S)-2-oxo-3-(4-(3-oxo-4-morpholinyl)phenyl)-1,3-oxazolidin-5-yl] methyl]-1H-isoindole-1,3(2H)-dione

Rivaroxaban Related Compound G

Rivaroxaban Phthalamide impurity

RIVAROXABAN EP IMPURITY G/ 2-[[(5S)-2-OXO-3-[4- (3-OXO-4-MORPHOLINYL)PHENYL]-5- OXAZOLIDINYL]METHYL]-1H-ISOINDOLE-1,3(2H)- DIONE (BAN-II)

(S)-2-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1

Rivaroxaban Impurity 2 (Rivaroxaban EP Impurity G)

(S)-2-((2-Oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)isoindoline-1,3-dione (Intermediate of Rivaroxaban)

446292-08-6

Chiral Reagents

Heterocycles

Intermediates & Fine Chemicals

Pharmaceuticals

Intermediate of Rivaroxaban