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5-R-Rivaroxaban

Product Name
5-R-Rivaroxaban
CAS No.
865479-71-6
Chemical Name
5-R-Rivaroxaban
Synonyms
R-Rivaroxaban;Rivaroxaban A;Rivaroxaban-6;ent-Rivaroxaban;5-R-Rivaroxaban;XARELTO; BAY 59-7939;Rivaroxaban R-Isomer;Rivaroxyban R-isomer;R-Rivaroxaban Impurity;R-Isomer of Rivaroxaban
CBNumber
CB02624033
Molecular Formula
C19H18ClN3O5S
Formula Weight
435.88
MOL File
865479-71-6.mol
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5-R-Rivaroxaban Property

Melting point:
>227°C (dec.)
Boiling point:
732.6±60.0 °C(Predicted)
Density 
1.460
storage temp. 
Refrigerator
solubility 
Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Methanol
form 
Solid
pka
13.36±0.46(Predicted)
color 
White to Off-White
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
R538005
Product name
ent-Rivaroxaban
Packaging
25mg
Price
$180
Updated
2021/12/16
Usbiological
Product number
448268
Product name
ent-Rivaroxaban
Packaging
10mg
Price
$368
Updated
2021/12/16
ChemScene
Product number
CS-0730
Product name
5-R-Rivaroxaban
Purity
99.72%
Packaging
50mg
Price
$370
Updated
2021/12/16
ApexBio Technology
Product number
A3126
Product name
5-R-Rivaroxaban
Packaging
50mg
Price
$370
Updated
2021/12/16
Medical Isotopes, Inc.
Product number
98910
Product name
ent-Rivaroxaban
Packaging
1mg
Price
$385
Updated
2021/12/16
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5-R-Rivaroxaban Chemical Properties,Usage,Production

Uses

ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Biological Activity

5-r-rivaroxaban is a selective inhibitor of human factor xa with ic50 value of 0.7 nmol/l [1].factor xa is a serine endopeptidase enzyme and plays an important role in the convergence point of the intrinsic and extrinsic pathways in blood coagulation system [2].5-r-rivaroxaban is an oral, direct factor xa inhibitor and the inhibition is species-dependent. when tested with purified factoe xa from human or rabbit, 5-r-rivaroxaban showed similar affinity with ic50 value of 0.7 nmol/l and 0.8 nmol/l, respectively, while had a ic50 value as low as 3.4 nmol/l when tested with rat factor xa [1].pre-treated anaesthetised rat model with intravenous 5-r-rivaroxaban at a dose of 2 mg/kg, and after bleeding initiated intravenous treated with rfviia (100/400 μg/kg), pcc (25/50 u/kg) or apcc (50/100 u/kg), the result showed that 5-r-rivaroxaban pre-treatment significantly shorten bleeding time and clotting time compared with 5-r-rivaroxaban alone treated group [2]. similar results were obtained when tested with rabbit model [1].it has been reported that 5-r-rivaroxaban is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic [3] [4] [1].

References

[1]. perzborn, e., et al., rivaroxaban: a new oral factor xa inhibitor. arterioscler thromb vasc biol, 2010. 30(3): p. 376-81.
[2]. perzborn, e., et al., reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. thromb haemost, 2013. 110(1): p. 162-72.
[3]. beyer-westendorf, j., et al., efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ortho-tep registry. j thromb haemost, 2012. 10(10): p. 2045-52.
[4]. palareti, g., et al., clinical management of rivaroxaban-treated patients. expert opin pharmacother, 2013. 14(5): p. 655-67.

5-R-Rivaroxaban Preparation Products And Raw materials

Raw materials

Preparation Products

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5-R-Rivaroxaban Suppliers

Chembest Research Laboratories Limited
Tel
021-20908456
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
6013
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61
Nanjing Chemlin Chemical Co., Ltd
Tel
025-83697070 13913916777;
Fax
+86-25-83453306
Email
info@chemlin.com.cn
Country
China
ProdList
17839
Advantage
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S.Z. PhyStandard Bio-Tech. Co., Ltd.
Tel
0755-83725681-603
Fax
+86 755 28094224
Country
China
ProdList
4505
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50
Beijing Comparison Pharmaceutical Technology Co., Ltd
Tel
010-52878169 15701683040
Email
sales@bjcomparison.com
Country
China
ProdList
4638
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58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7553
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61
Shanghai Aladdin Bio-Chem Technology Co.,LTD
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400-6206333 18521732826;
Fax
021-50323701
Email
market@aladdin-e.com
Country
China
ProdList
24835
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MedChemexpress LLC
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021-58955995
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609-228-5909
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sales@medchemexpress.cn
Country
United States
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4863
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58
AdooQ BioScience, LLC
Tel
+1 (866) 930-6790
Fax
+1 (866) 333-9607
Email
info@adooq.com
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United States
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2784
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TargetMol Chemicals Inc.
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021-33632979 15002134094
Fax
021-33632979
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marketing@targetmol.com
Country
China
ProdList
7934
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58
Shanghai Hekang Biotechnology Co., Ltd.
Tel
18939837085
Fax
2880152141(QQ)
Email
youchemicals@gmail.com
Country
China
ProdList
1813
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865479-71-6, 5-R-RivaroxabanRelated Search:


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