3-Morpholinone, 4-phenyl-
- Product Name
- 3-Morpholinone, 4-phenyl-
- CAS No.
- 29518-11-4
- Chemical Name
- 3-Morpholinone, 4-phenyl-
- Synonyms
- 4-Phenylmorpholin-3-one;4-Phenyl-3-morpholinone;3-Morpholinone, 4-phenyl-
- CBNumber
- CB21871872
- Molecular Formula
- C10H11NO2
- Formula Weight
- 177.2
- MOL File
- 29518-11-4.mol
3-Morpholinone, 4-phenyl- Property
- Melting point:
- 113-114℃
- Boiling point:
- 395.2±35.0 °C(Predicted)
- Density
- 1.187
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- Chloroform (Slightly), DMSO (Slightly)
- pka
- 0.27±0.20(Predicted)
- form
- Solid
- color
- Off-White
Safety
- HazardClass
- IRRITANT
- HS Code
- 2934999090
N-Bromosuccinimide Price
- Product number
- P322550
- Product name
- 4-Phenyl-3-morpholinone
- Packaging
- 1g
- Price
- $155
- Updated
- 2021/12/16
- Product number
- 056506
- Product name
- 4-Phenylmorpholin-3-one
- Purity
- >95%
- Packaging
- 1g
- Price
- $100
- Updated
- 2021/12/16
- Product number
- Z6138
- Product name
- 4-Phenyl-3-morpholinone
- Packaging
- 5g
- Price
- $216
- Updated
- 2021/12/16
- Product number
- 056506
- Product name
- 4-Phenylmorpholin-3-one
- Purity
- >95%
- Packaging
- 5g
- Price
- $240
- Updated
- 2021/12/16
- Product number
- OR950870
- Product name
- 4-Phenylmorpholin-3-one
- Purity
- 95%
- Packaging
- 5g
- Price
- $370
- Updated
- 2021/12/16
3-Morpholinone, 4-phenyl- Chemical Properties,Usage,Production
Uses
4-Phenyl-3-morpholinone is used in studies to evaluate the bactericidal activity.
Synthesis
79-04-9
122-98-5
29518-11-4
Example 1: Preparation of 4-phenylmorpholin-3-one To a solution of N-phenylethanolamine (6.0 mL, 47.8 mmol) in isopropanol (IPA, 6 mL) heated to 40°C was added chloroacetyl chloride (11.4 mL, 143.4 mmol) and 10 N sodium hydroxide solution (29.6 mL, 296 mmol) dropwise at the same time, keeping the pH of the reaction system between 7 and 8. After dropwise addition, the reaction mixture was continued to be stirred at 40 °C for 10 min, followed by cooling to 0 °C and stirring for 1 h at that temperature. Upon completion of the reaction, the white solid product formed was collected by filtration, washed with cold water and dried to afford 4-phenylmorpholin-3-one (5.27 g, 62% yield) as a white solid. The structure of the product was confirmed by 1H NMR (400 MHz, CDCl3): δ 7.42 (t, J = 8.0 Hz, 2H), 7.34-7.27 (m, 3H), 4.35 (s, 2H), 4.04 (t, J = 5.2 Hz, 2H), 3.77 (t, J = 5.2 Hz, 2H).
References
[1] European Journal of Medicinal Chemistry, 2015, vol. 95, p. 388 - 399
[2] Patent: WO2005/26135, 2005, A1. Location in patent: Page/Page column 6
[3] Patent: WO2011/12321, 2011, A1. Location in patent: Page/Page column 30
[4] Helvetica Chimica Acta, 2013, vol. 96, # 11, p. 2160 - 2172
[5] Patent: WO2011/80341, 2011, A1. Location in patent: Page/Page column 14; 15
3-Morpholinone, 4-phenyl- Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-Morpholinone, 4-phenyl- manufacturers
- Product
- 4-Phenyl-3-Morpholinone 29518-11-4
- Price
- US $2.00-5.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 100kg
- Release date
- 2025-06-27
- Product
- 3-Morpholinone,4-phenyl- 29518-11-4
- Price
- US $1.00/g
- Min. Order
- 1g
- Purity
- 99%
- Supply Ability
- T
- Release date
- 2019-12-17