5-R-Rivaroxaban

ChemicalBook > CAS DataBase List > 5-R-Rivaroxaban

Product Name: 5-R-Rivaroxaban
CAS No.: 865479-71-6
Chemical Name: 5-R-Rivaroxaban
Synonyms: R-Rivaroxaban;Rivaroxaban A;Rivaroxaban-6;ent-Rivaroxaban;5-R-Rivaroxaban;XARELTO; BAY 59-7939;Rivaroxaban R-Isomer;Rivaroxyban R-isomer;R-Rivaroxaban Impurity;R-Isomer of Rivaroxaban
CBNumber: CB02624033
Molecular Formula: C19H18ClN3O5S
Formula Weight: 435.88
MOL File: 865479-71-6.mol

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5-R-Rivaroxaban Property

Melting point:: >227°C (dec.)
Boiling point:: 732.6±60.0 °C(Predicted)
Density: 1.460
storage temp.: Refrigerator
solubility: Acetonitrile (Slightly, Heated, Sonicated), DMSO (Slightly, Sonicated), Methanol
form: Solid
pka: 13.36±0.46(Predicted)
color: White to Off-White

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: R538005
Product name: ent-Rivaroxaban
Packaging: 25mg
Price: $180
Updated: 2021/12/16

Usbiological

Product number: 448268
Product name: ent-Rivaroxaban
Packaging: 10mg
Price: $368
Updated: 2021/12/16

ChemScene

Product number: CS-0730
Product name: 5-R-Rivaroxaban
Purity: 99.72%
Packaging: 50mg
Price: $370
Updated: 2021/12/16

ApexBio Technology

Product number: A3126
Product name: 5-R-Rivaroxaban
Packaging: 50mg
Price: $370
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 98910
Product name: ent-Rivaroxaban
Packaging: 1mg
Price: $385
Updated: 2021/12/16

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5-R-Rivaroxaban Chemical Properties,Usage,Production

Uses

ent-Rivaroxaban is the R-isomer of Rivaroxaban (R538000), which is a novel antithrombotic agent. A highly potent and selective, direct FXa inhibitor.

Biological Activity

5-r-rivaroxaban is a selective inhibitor of human factor xa with ic50 value of 0.7 nmol/l [1].factor xa is a serine endopeptidase enzyme and plays an important role in the convergence point of the intrinsic and extrinsic pathways in blood coagulation system [2].5-r-rivaroxaban is an oral, direct factor xa inhibitor and the inhibition is species-dependent. when tested with purified factoe xa from human or rabbit, 5-r-rivaroxaban showed similar affinity with ic50 value of 0.7 nmol/l and 0.8 nmol/l, respectively, while had a ic50 value as low as 3.4 nmol/l when tested with rat factor xa [1].pre-treated anaesthetised rat model with intravenous 5-r-rivaroxaban at a dose of 2 mg/kg, and after bleeding initiated intravenous treated with rfviia (100/400 μg/kg), pcc (25/50 u/kg) or apcc (50/100 u/kg), the result showed that 5-r-rivaroxaban pre-treatment significantly shorten bleeding time and clotting time compared with 5-r-rivaroxaban alone treated group [2]. similar results were obtained when tested with rabbit model [1].it has been reported that 5-r-rivaroxaban is a promising drug for atrial fibrillation, venous thromboembolism or thromboembolic disorders in clinic [3] [4] [1].

References

[1]. perzborn, e., et al., rivaroxaban: a new oral factor xa inhibitor. arterioscler thromb vasc biol, 2010. 30(3): p. 376-81.
[2]. perzborn, e., et al., reversal of rivaroxaban anticoagulation by haemostatic agents in rats and primates. thromb haemost, 2013. 110(1): p. 162-72.
[3]. beyer-westendorf, j., et al., efficacy and safety of rivaroxaban or fondaparinux thromboprophylaxis in major orthopedic surgery: findings from the ortho-tep registry. j thromb haemost, 2012. 10(10): p. 2045-52.
[4]. palareti, g., et al., clinical management of rivaroxaban-treated patients. expert opin pharmacother, 2013. 14(5): p. 655-67.

5-R-Rivaroxaban Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from 5-R-Rivaroxaban manufacturers

Henan Fengda Chemical Co., Ltd

Product: 5-R-Rivaroxaban 865479-71-6
Price: US $8.00-2.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-04-25

865479-71-6, 5-R-RivaroxabanRelated Search:

4-(3-nitrophenyl)-3-Morpholinone 3-Morpholinone, 4-phenyl- 3-MORPHOLINONE, 4-[4-[(5S)-5-(AMINOMETHYL)-2-OXO-3-OXAZOLIDINYL]PHENYL]- Palbociclib Impurity 21 3'-N-DesMethyl-3'-N-tosyl AzithroMycin [[p-(2-methoxyethyl)phenoxy]methyl]oxirane 1,2-BenzenedicarboxaMide, N1,N2-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 1H-ISOINDOLE-1,3(2H)-DIONE, 2-[[(5S)-2-OXO-3-[4-(3-OXO-4-MORPHOLINYL)PHENYL]-5-OXAZOLIDINYL]METHYL]- Rivaroxaban (S)-4,5-dichloro-N-((2-oxo-3-(4-(3-oxoMorpholino)phenyl)oxazolidin-5-yl)Methyl)thiophene-2-carboxaMide Urea, N,N'-bis[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- AcetaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 2-ThiophenecarboxaMide, N-[[(5S)-2-oxo-3-[4-(3-oxo-4-Morpholinyl)phenyl]-5-oxazolidinyl]Methyl]- 5-Methyl-2-thiophenecarboxylic acid 5-chloro-N-(4-((S)-5-((5-chlorothiophene-2-carboxamido)methyl)-2-oxooxazolidin-3-yl)phenyl)-N-(2-(2-oxo-2-((((S)-2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)amino)ethoxy)ethyl)thiophene-2-carboxamide 3,5-dichlorothiophene-2-carboxylic acid Rivaroxaban Impurity H 1H-Benzotriazole, 1-hydroxy-, sodium salt

5-R-Rivaroxaban

5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

R-Rivaroxaban

(R)-5-chloro-N-((2-oxo-3-(4-(3-oxomorpholino)phenyl)oxazolidin-5-yl)methyl)thiophene-2-carboxamide

ent-Rivaroxaban

Rivaroxaban R-Isomer Impurity

(R)-Rivaroxaban, ent-Rivaroxaban

Rivaroxaban R-Isomer

Rivaroxaban Impurity 6(Rivaroxaban R-Isomer)

(S)-4-(4-(5-(((2-methyl-4-oxopentan-2-yl)amino)methyl)-2- oxooxazolidin-3-yl)phenyl)morpholin-3-one

XARELTO; BAY 59-7939

Rivaroxaban impurity H: 5-R Rivaroxaban

Rivaroxaban A

2-Thiophenecarboxamide, 5-chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-

Rivaroxaban impurity 7/5-R-Rivaroxaban/ent-Rivaroxaban/5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxo-4-morpholinyl)phenyl]-5-oxazolidinyl]methyl]-2-thiophenecarboxamide

Rivaroxaban-6

R-Rivaroxaban Impurity

Rivaroxaban R-Isomer (ent-Rivaroxaban)

Rivaroxaban EP Impurity A/Rivaroxaban R-isomer Impurity

Rivaroxyban R-isomer

R-ENANTIOMER OF RIVAROXABAN

Rivaroxaban Impurities364

Rivaroxaban EP Impurity A

5-Chloro-N-[[(5R)-2-oxo-3-[4-(3-oxomorpholin-4-yl)phenyl]-1,3-oxazolidin-5-yl]methyl]thiophene-2-carboxamide

Rivaroxaban Enantiomer (R-Isomer)

R-Isomer of Rivaroxaban

865479-71-6