6-BROMO-BENZOXAZOLINONE
- Product Name
- 6-BROMO-BENZOXAZOLINONE
- CAS No.
- 19932-85-5
- Chemical Name
- 6-BROMO-BENZOXAZOLINONE
- Synonyms
- Cincreasin;6-BROMOBENZOXAZOLINE;6-Bromobenzoxazolone;6-BROMO-BENZOXAZOLINONE;6-Bromo-2-benzoxazolone;6-broMobenzoxazol-2-one;Venadaparib Impurity 83;6-Bromo-2-benzoxazolinone;6-bromobenzo[d]oxazol-2-ol;6-Bromo-3H-benzoxazol-2-one
- CBNumber
- CB1511956
- Molecular Formula
- C7H4BrNO2
- Formula Weight
- 214.02
- MOL File
- 19932-85-5.mol
6-BROMO-BENZOXAZOLINONE Property
- Melting point:
- 192-196 °C
- Boiling point:
- -2.6°C (rough estimate)
- Density
- 1.809
- refractive index
- 1.6120 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- soluble in Methanol
- form
- powder to crystal
- pka
- 8.34±0.70(Predicted)
- color
- White to Light yellow to Dark green
- CAS DataBase Reference
- 19932-85-5
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 697036
- Product name
- 6-Bromo-2-benzoxazolinone
- Purity
- 97%
- Packaging
- 1g
- Price
- $116
- Updated
- 2022/05/15
- Product number
- B5290
- Product name
- 6-Bromo-2-benzoxazolinone
- Packaging
- 1G
- Price
- $96
- Updated
- 2025/07/31
- Product number
- B5290
- Product name
- 6-Bromo-2-benzoxazolinone
- Packaging
- 5G
- Price
- $283
- Updated
- 2025/07/31
- Product number
- B807868
- Product name
- 6-Bromobenzo[d]oxazol-2(3H)-one
- Packaging
- 100mg
- Price
- $60
- Updated
- 2021/12/16
- Product number
- B807868
- Product name
- 6-Bromobenzo[d]oxazol-2(3H)-one
- Packaging
- 500mg
- Price
- $155
- Updated
- 2021/12/16
6-BROMO-BENZOXAZOLINONE Chemical Properties,Usage,Production
Chemical Properties
White solid
Definition
ChEBI: A member of the class of benzoxazoles that is 2-benzoxazolinone substituted at position 6 by a bromo group.
Synthesis
59-49-4
19932-85-5
General procedure for the synthesis of 6-bromobenzo[d]oxazol-2(3H)-ones from 2-benzoxazolidinones: 3H-1,3-benzoxazol-2-one (5.00 g, 37.00 mmol) was dissolved in acetic acid (50 mL), and bromine (1.9 mL, 37.0 mmol) was slowly added dropwise. The reaction mixture was stirred at 20°C for 4 hours. After completion of the reaction, the mixture was poured into ice water, the precipitate was collected by filtration, washed with water and dried over air to give a pink solid product (7.48 g, 34.8 mmol, 94% yield). The melting point of the product was 191.6-192.3 °C. 1H NMR (300 MHz, DMSO-d6): δ 11.81 (s, 1H), 7.57 (dd, J=1.9 Hz, 0.3 Hz, 1H), 7.30 (dd, J=8.3 Hz, 1.9 Hz, 1H), 7.04 (dd, J=8.3 Hz, 0.3 Hz, 1H) .13C NMR (75MHz, DMSO-d6): δ154.5, 144.5, 130.3, 126.9, 113.5, 113.2, 111.7.LCMS m/z calculated values [M-H]+: 211.9, 213.9; measured values: 211.8, 213.8.
References
[1] European Journal of Medicinal Chemistry, 2018, vol. 159, p. 104 - 125
[2] Patent: US6372933, 2002, B1. Location in patent: Page column 5 - 6
[3] Patent: US2008/138413, 2008, A1. Location in patent: Page/Page column 22
[4] Monatshefte fur Chemie, 2011, vol. 142, # 1, p. 67 - 80
[5] Patent: EP1251128, 2002, A1. Location in patent: Page 38
6-BROMO-BENZOXAZOLINONE Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 6-BROMO-BENZOXAZOLINONE manufacturers
- Product
- 6-bromobenzo[d]oxazol-2(3H)-one 19932-85-5
- Price
- US $0.00/KG
- Min. Order
- 1KG
- Purity
- 97.7%
- Supply Ability
- 100 tons
- Release date
- 2022-01-14
- Product
- 6-BROMO-BENZOXAZOLINONE 19932-85-5
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 99%
- Supply Ability
- 1000KGS
- Release date
- 2019-12-25