ChemicalBook > CAS DataBase List > Mc-Val-Ala-PAB-PNP

Mc-Val-Ala-PAB-PNP

Product Name: Mc-Val-Ala-PAB-PNP
CAS No.: 1639939-40-4
Chemical Name: Mc-Val-Ala-PAB-PNP
Synonyms: Mc-Val-Ala-PAB-PNP;inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP;L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate;[4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate
CBNumber: CB15479729
Molecular Formula: C32H37N5O10
Formula Weight: 651.66
MOL File: 1639939-40-4.mol

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Mc-Val-Ala-PAB-PNP Property

Boiling point:: 946.4±65.0 °C(Predicted)
Density: 1.323±0.06 g/cm3(Predicted)
storage temp.: -20°C, protect from light, stored under nitrogen
form: Solid
pka: 13.31±0.70(Predicted)
color: White to off-white
InChIKey: VMOQJVBAOUFRSX-LGGPFLRQSA-N
SMILES: C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Iris Biotech GmbH

Product number: ADC1280
Product name: MC-Val-Ala-PAB-PNP
Packaging: 100mg
Price: $506.25
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1280
Product name: MC-Val-Ala-PAB-PNP
Packaging: 250mg
Price: $1012.5
Updated: 2021/12/16

Iris Biotech GmbH

Product number: ADC1280
Product name: MC-Val-Ala-PAB-PNP
Packaging: 1g
Price: $3037.5
Updated: 2021/12/16

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Mc-Val-Ala-PAB-PNP Chemical Properties,Usage,Production

Uses

Mc-Val-Ala-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Cryptophycin-55 (CR55) can be conjugated to the model antibody trastuzumab (an anti-HER2 antibody drug approved by the FDA for the treatment of breast cancer) through the linker of Mc-NHS and Mc-Val-Cit-PAB-PNP to prepare trastuzumab-CR55 conjugates. These conjugates exhibit potent cytotoxicity in HER2-positive tumor cell lines, with IC50 values at low nanomolar levels (0.58-1.19 nM)^[1].

Biological Activity

MC-Val-Ala-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs).

in vitro

ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

IC 50

Protease Cleavable Linker; Cleavable Linker

References

[1] QINHUAI LAI . Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies[J]. European Journal of Medicinal Chemistry, 2020. DOI:10.1016/j.ejmech.2020.112364.

Mc-Val-Ala-PAB-PNP Preparation Products And Raw materials

Raw materials

Preparation Products

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1639939-40-4, Mc-Val-Ala-PAB-PNPRelated Search:

Mc-Val-Ala-PAB-PNP

L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-

4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate

inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP

[4-[[(2S)-2-[[(2S)-2-[6-(2,5-dioxopyrrol-1-yl)hexanoylamino]-3-methylbutanoyl]amino]propanoyl]amino]phenyl]methyl (4-nitrophenyl) carbonate

1639939-40-4

Linker

ADC LINKER