Mc-Val-Ala-PAB-PNP
- Product Name
- Mc-Val-Ala-PAB-PNP
- CAS No.
- 1639939-40-4
- Chemical Name
- Mc-Val-Ala-PAB-PNP
- Synonyms
- Mc-Val-Ala-PAB-PNP;inhibit,ADC Linkers,Inhibitor,MC Val Ala PAB PNP,Antibody-drug conjugates linkers,MCValAlaPABPNP;L-Alaninamide, N-[6-(2,5-dihydro-2,5-dioxo-1H-pyrrol-1-yl)-1-oxohexyl]-L-valyl-N-[4-[[[(4-nitrophenoxy)carbonyl]oxy]methyl]phenyl]-;4-((S)-2-((S)-2-(6-(2,5-Dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamido)-3-methylbutanamido)propanamido)benzyl (4-nitrophenyl) carbonate
- CBNumber
- CB15479729
- Molecular Formula
- C32H37N5O10
- Formula Weight
- 651.66
- MOL File
- 1639939-40-4.mol
Mc-Val-Ala-PAB-PNP Property
- Boiling point:
- 946.4±65.0 °C(Predicted)
- Density
- 1.323±0.06 g/cm3(Predicted)
- pka
- 13.31±0.70(Predicted)
- form
- Solid
- color
- White to off-white
- InChIKey
- VMOQJVBAOUFRSX-LGGPFLRQSA-N
- SMILES
- C(N)(=O)[C@H](C)N(C(=O)[C@H](C(C)C)NC(=O)CCCCCN1C(=O)C=CC1=O)C1=CC=C(COC(OC2=CC=C([N+]([O-])=O)C=C2)=O)C=C1
N-Bromosuccinimide Price
- Product number
- ADC1280
- Product name
- MC-Val-Ala-PAB-PNP
- Packaging
- 100mg
- Price
- $506.25
- Updated
- 2021/12/16
- Product number
- ADC1280
- Product name
- MC-Val-Ala-PAB-PNP
- Packaging
- 250mg
- Price
- $1012.5
- Updated
- 2021/12/16
- Product number
- ADC1280
- Product name
- MC-Val-Ala-PAB-PNP
- Packaging
- 1g
- Price
- $3037.5
- Updated
- 2021/12/16
Mc-Val-Ala-PAB-PNP Chemical Properties,Usage,Production
Uses
Mc-Val-Ala-PAB-PNP is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs). Cryptophycin-55 (CR55) can be conjugated to the model antibody trastuzumab (an anti-HER2 antibody drug approved by the FDA for the treatment of breast cancer) through the linker of Mc-NHS and Mc-Val-Cit-PAB-PNP to prepare trastuzumab-CR55 conjugates. These conjugates exhibit potent cytotoxicity in HER2-positive tumor cell lines, with IC50 values at low nanomolar levels (0.58-1.19 nM)[1].
Biological Activity
MC-Val-Ala-PAB-PNP is a cleavable ADC linker that can be used to synthesize antibody-drug conjugates (ADCs).
in vitro
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
|
References
[1] QINHUAI LAI . Cryptophycin-55/52 based antibody-drug conjugates: Synthesis, efficacy, and mode of action studies[J]. European Journal of Medicinal Chemistry, 2020. DOI:10.1016/j.ejmech.2020.112364.
Mc-Val-Ala-PAB-PNP Preparation Products And Raw materials
Raw materials
Preparation Products
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