Remdesivir N-2
- Product Name
- Remdesivir N-2
- CAS No.
- 1191237-80-5
- Chemical Name
- Remdesivir N-2
- Synonyms
- GS-5;remdesivir N-2;Remdesivir-015;NSJ-Remdesivir-RS009;Remdesivir Impurity 7;Remdesivir Intermediate 2;Remdesivir Intermediate 4;Remdesivir Related Compound 7;Remdesivir No. 5 Intermediate;Remdesivir O-desphosphate acetonide
- CBNumber
- CB15493006
- Molecular Formula
- C15H17N5O4
- Formula Weight
- 331.33
- MOL File
- 1191237-80-5.mol
Remdesivir N-2 Property
- Density
- 1.66±0.1 g/cm3(Predicted)
- solubility
- DMSO:55.5(Max Conc. mg/mL);167.51(Max Conc. mM)
Ethanol:5.0(Max Conc. mg/mL);15.09(Max Conc. mM)
PBS (pH 7.2):0.3(Max Conc. mg/mL);0.91(Max Conc. mM)
DMF:12.0(Max Conc. mg/mL);36.22(Max Conc. mM) - form
- A solid
- pka
- 14.14±0.10(Predicted)
- color
- Off-white to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0131976
- Product name
- RemdesivirO-desphosphateacetonideimpurity
- Purity
- 99.88%
- Packaging
- 1mg
- Price
- $230
- Updated
- 2021/12/16
- Product number
- A1220957
- Product name
- (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
- Purity
- 97%
- Packaging
- 1g
- Price
- $285
- Updated
- 2021/12/16
- Product number
- A1220957
- Product name
- (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
- Purity
- 97%
- Packaging
- 5g
- Price
- $1048
- Updated
- 2021/12/16
- Product number
- A1220957
- Product name
- (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
- Purity
- 97%
- Packaging
- 100mg
- Price
- $80
- Updated
- 2021/12/16
- Product number
- A1220957
- Product name
- (3aR,4R,6R,6aR)-4-(4-Aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxole-4-carbonitrile
- Purity
- 97%
- Packaging
- 250mg
- Price
- $115
- Updated
- 2021/12/16
Remdesivir N-2 Chemical Properties,Usage,Production
Uses
Remdesivir N-2 can be used as organic synthesis intermediates and pharmaceutical intermediates, mainly used in the research and development and chemical production of Remdesivir.
Synthesis
5.62g of compound GS-441524 was dissolved in 30mL of acetone, 11.50mL of 2,2-dimethoxypropane and 1.34mL of sulfuric acid were added, stirred at 45??C for half an hour, cooled to 25??C, and the organic solvent was removed by rotary evaporation. It was extracted with 100 mL of ethyl acetate and 100 mL of saturated sodium bicarbonate aqueous solution, and the extraction was repeated three times. The ethyl acetate layers were combined, dried by adding anhydrous sodium sulfate, and filtered to remove sodium sulfate. The organic solvent was removed by rotary evaporation, and column chromatography was performed (eluent: petroleum ether/ethyl acetate (V/V)=1/2) to obtain 6.20 g of compound 5 (white solid, 97% yield).
Remdesivir N-2 Preparation Products And Raw materials
Raw materials
Preparation Products
Remdesivir N-2 Suppliers
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View Lastest Price from Remdesivir N-2 manufacturers
- Product
- D-Altrononitrile, 2-C-(4-aminopyrrolo[2,1-f][1,2,4]triazin-7-yl)-2,5-anhydro-3,4-O-(1-methylethylidene)- 1191237-80-5
- Price
- US $0.10/KG
- Min. Order
- 1KG
- Purity
- 99.0%
- Supply Ability
- 1000 tons
- Release date
- 2020-04-27
- Product
- Remdesivir N-2 1191237-80-5
- Price
- US $80.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10000tons
- Release date
- 2023-09-11
- Product
- Remdesivir O-desphosphate acetonide impurity 1191237-80-5
- Price
- US $5.80/KG
- Min. Order
- 1KG
- Purity
- 98%
- Supply Ability
- 10KG
- Release date
- 2021-09-24