Applications Immunogen Background

CDC37 antibody

Applications Immunogen Background
Product Name
CDC37 antibody
Chemical Name
CDC37 antibody
Synonyms
CDC37 antibody;Mouse Monoclonal CDC37 Antibody
CBNumber
CB15616238
Formula Weight
0
MOL File
Mol file
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Biorbyt Ltd
Product number
orb100175
Product name
CDC37 antibody
Purity
Affinity purified by Protein A
Packaging
100μg
Price
$421.6
Updated
2021/12/16
Biorbyt Ltd
Product number
orb100175
Product name
CDC37 antibody
Purity
Affinity purified by Protein A
Packaging
200μg
Price
$673.2
Updated
2021/12/16
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CDC37 antibody Chemical Properties,Usage,Production

Applications

The antibody has been tested by ELISA, Western blot analysis, Flow cytometry and ICC/IF to assure specificity and reactivity.

Immunogen

Anti-human CDC37 mAb, is derived from hybridization of mouse F0 myeloma cells with spleen cells from BALB/c mice immunized with a recombinant human CDC37 protein 1-378 amino acids purified from E. coli.

Background

CDC37 is an essential protein in Saccharomyces cerevisiae and is a molecular chaperone with precise function in cell signal transduction. CDC37 forms a complex/associates with Hsp90 molecular chaperone as one of several auxiliary proteins that are collectively referred to as Hsp90 co-chaperones. CDC37 also forms complex with a number of protein kinases such as CDK4, CDK6, SRC, RAF-1, MOK, as well as eIF2 alpha kinases. CDC34 is involved in directing Hsp90 to its target kinases. CDC37 up-regulation is a common early event in some localized human cancers. CDC37 is necessary for maintaining prostate tumor cell growth and represents a novel target in the exploration for multitargeted therapies. CDC37 plays a role in regulating Hsp90 ATPase activity. CDC37 binds to Akt and HSP90 in the signal transduction pathway in human tumor cells. Tnf-induced recruitment and activation of the IKK complex require Cdc37 and Hsp90. CDC37 and heat shock protein 90 bind specifically to the kinase domain of LKB1.

CDC37 antibody Preparation Products And Raw materials

Raw materials

Preparation Products

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CDC37 antibody Suppliers

China 59 Global 59
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  • CDC37 antibody
  • Mouse Monoclonal CDC37 Antibody