CENPE antibody
Source Reactivity Background References- Product Name
- CENPE antibody
- Chemical Name
- CENPE antibody
- Synonyms
- CENPE antibody
- CBNumber
- CB15616793
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb221389
- Product name
- CENPE antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb221389
- Product name
- CENPE antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
CENPE antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human
Background
Centromere-associated protein E is a kinesin-like motor protein and mitotic-checkpoint kinase BUB1B binding partner that is essential for establishing and maintaining stable attachments between mitotic chromosomes and spindle microtubules. CENP-E plays an important role as a motor protein in the alignment of chromosomes during prometaphase. Research studies indicate that CENP-E protein expression peaks in late G2 and M-phases of the cell cycle before the protein is degraded at mitotic exit. Additional studies show that the loss of CENP-E function results in cell cycle arrest in mitosis. Mutations in the corresponding CENPE gene can result in autosomal recessive primary microcephaly-13, a developmental disorder characterized by small head circumference, dysmorphic facial features, short stature, and delayed psychomotor development. Since CENP-E is essential for mitotic progression and is required for cellular proliferation, it has become an interesting target for cancer therapy.
References
[1] Yao, X. et al. (2000) Nat Cell Biol 2, 484-91.
[2] Yardimci, H. et al. (2008) Proc Natl Acad Sci U S A 105, 6016-21.
[3] Brown, K.D. et al. (1994) J Cell Biol 125, 1303-12.
[4] Mirzaa, G.M. et al. (2014) Hum Genet 133, 1023-1039.
[5] Wood, K.W. et al. (2008) Clin Cancer Res 14, 7588-92.
[6] Balamuth, N.J. et al. (2010) Cancer Res 70, 2749-58.
[7] Kung, P.P. et al. (2014) Mol Cancer Ther 13, 2104-15.
CENPE antibody Preparation Products And Raw materials
Raw materials
Preparation Products
CENPE antibody Suppliers
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