DAPK1 antibody
Source Reactivity Background References- Product Name
- DAPK1 antibody
- Chemical Name
- DAPK1 antibody
- Synonyms
- DAPK1 antibody;Rabbit Polyclonal DAPK1 Antibody
- CBNumber
- CB15621559
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb10533
- Product name
- DAPK1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb10533
- Product name
- DAPK1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
DAPK1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse
Background
Death-associated protein kinase is a Ca2+/calmodulin-regulated serine/threonine kinase that participates in a wide range of apoptotic signals including interferon-γ, tumor necrosis factor α, Fas, activated c-Myc, and detachment from the extracellular matrix. In addition to the kinase domain and calmodulin regulatory segment, DAPK1 also has eight ankyrin repeats, a cytoskeleton binding region, and a conserved death domain. Deletion of the calmodulin-regulatory domain generates a constitutively active mutant kinase. Ectopic expression of wild-type DAPK1 induced cell death in HeLa cells. Conversely, expression of a catalytically inactive mutant protected cells from interferon-γ-induced cell death. The catalytic domain of DAPK1 has very high sequence similarity to vertebrate myosin light chain kinase and a RXX(S/T)X motif derived from myosin light chain protein was shown to be phosphorylated in vitro by DAPK1.Epigenetic silencing of DAPK1 by promoter methylation has been observed in cases of chronic lymphocytic leukemia.
References
[1] Kimchi, A. (1999) Ann Rheum Dis. 58, I14-I19.
[2] Cohen, O. et al. (1999) J Cell Biol 146, 141-148.
[3] Deiss, L. P. et al. (1995) Genes Dev 9, 15-30.
[4] Cohen, O. et al. (1997) EMBO J 16, 998-1008.
[5] Velentza, A. V. et al. (2001) J Biol Chem 276, 38956-38965.
[6] Raval, A. et al. (2007) Cell 129, 879-890.
[7] Katzenellenbogen, R.A. et al. (1999) Blood 93, 4347-4353.
DAPK1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
DAPK1 antibody Suppliers
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