FXR1 antibody
Source Reactivity Background References- Product Name
- FXR1 antibody
- Chemical Name
- FXR1 antibody
- Synonyms
- FXR1 antibody
- CBNumber
- CB15628912
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb4646
- Product name
- FXR1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb4646
- Product name
- FXR1 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
FXR1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
Fragile X syndrome is a genetic disorder characterized by a spectrum of physical and behavioral features and is a frequent form of inherited mental retardation. X-linked FMRP and its two autosomal homologs, FXR1 and FXR2, are polyribosome-associated RNA-binding proteins that are involved in the pathogenesis of fragile X syndrome. Each of the fragile X proteins can self-associate, as well as form heteromers with the other two related proteins. FMRP can act as a translation regulator and is a component of RNAi effector complexes, suggesting a role in gene silencing. The Drosophila homolog of FMRP associates with Argonaute 2 and Dicer and can coimmunoprecipitate with miRNA and siRNA. These results suggest that fragile X syndrome is related to abnormal translation caused by defects in RNAi-related pathways. In addition, FMRP, FXR1, and FXR2 are components of stress granules and have been implicated in the translational regulation of mRNAs.
References
[1] Verkerk, A.J. et al. (1991) Cell 65, 905-14.
[2] Siomi, M.C. et al. (1995) EMBO J 14, 2401-8.
[3] Zhang, Y. et al. (1995) EMBO J 14, 5358-66.
[4] Caudy, A.A. et al. (2002) Genes Dev 16, 2491-6.
[5] Siomi, H. et al. (2004) Ment Retard Dev Disabil Res Rev 10, 68-74.
[6] Linder, B. et al. (2008) Hum Mol Genet 17, 3236-6.
FXR1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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