LRP1 antibody
Source Reactivity Background References- Product Name
- LRP1 antibody
- Chemical Name
- LRP1 antibody
- Synonyms
- LRP1 antibody;Mouse Monoclonal LRP1 Antibody
- CBNumber
- CB15651846
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb88136
- Product name
- LRP1 antibody
- Purity
- Protein G Column
- Packaging
- 50μg
- Price
- $725.9
- Updated
- 2021/12/16
- Product number
- orb88361
- Product name
- LRP1 antibody
- Purity
- Protein A Column
- Packaging
- 50μg
- Price
- $725.9
- Updated
- 2021/12/16
LRP1 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
Low density lipoprotein receptor related protein 1 is a type I transmembrane receptor that mediates the endocytosis of various ligands. LRP1 plays important roles in lipid homeostasis, signaling transduction, embryonic development, and glucose metabolism. In addition, LRP1 regulates APP processing and facilitates the clearance of beta-amyloid. This finding makes LRP1 a potential therapeutic target for Alzheimer’s disease. LRP1 preprotein is proteolytically processed by furin to generate a 515 kDa extracellular α subunit and a membrane-anchored 85 kDa β subunit, which together form the mature receptor.
References
[1] Lillis, A.P. et al. (2008) Physiol Rev 88, 887-918.
[2] Herz, J. et al. (1988) EMBO J 7, 4119-27.
[3] van der Geer, P. (2002) Trends Cardiovasc Med 12, 160-5.
[4] May, P. and Herz, J. (2003) Traffic 4, 291-301.
[5] Zilberberg, A. et al. (2004) J Biol Chem 279, 17535-42.
[6] Hofmann, S.M. et al. (2007) J Clin Invest 117, 3271-82.
[7] Cam, J.A. et al. (2005) J Biol Chem 280, 15464-70.
[8] Bu, G. et al. (2006) Ann N Y Acad Sci 1086, 35-53.
[9] Bell, R.D. et al. (2009) Nat Cell Biol 11, 143-53.
[10] Willnow, T.E. et al. (1996) Biochem J 313 (Pt 1), 71-6.
LRP1 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
LRP1 antibody Suppliers
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