HCV E2
Description Source Background- Product Name
- HCV E2
- Chemical Name
- HCV E2
- Synonyms
- HCV E2
- CBNumber
- CB15733328
- Formula Weight
- 0
- MOL File
- Mol file
HCV E2 Chemical Properties,Usage,Production
Description
Recombinant Hepatitis C Virus E2 Genotype-1 produced in E. coli is a single polypeptide chain containing 226 amino acids (aa 482-671) and having a molecular mass of 25.4kDa (NCBI Accession#NP_671491).
HCV E2 is fused to a 36 amino acid His-tag at N-terminus.
Source
Escherichia Coli
Background
E1 and E2 glycoproteins form a heterodimer which is involved in virus attachment to the host cell, virion internalization via clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, however this binding insufficient for infection, some additional liver specific cofactors may be required. The fusion function may perhaps be conducted by E1. E2 hinders human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively located on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow seizure of circulating HCV particles by these cells and subsequent diffusion to permissive cells.
HCV E2 Preparation Products And Raw materials
Raw materials
Preparation Products
HCV E2 Suppliers
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