ChemicalBook > CAS DataBase List > YKL-06-062
YKL-06-062
- Product Name
- YKL-06-062
- CAS No.
- 2172617-16-0
- Chemical Name
- YKL-06-062
- Synonyms
- YKL-06-062;YKL06062,YKL 06 062;YKL-06-062, 10 mM in DMSO;1-Cyclohexyl-3-(2,6-dimethylphenyl)-7-((4-(4-methylpiperazin-1-yl)phenyl)amino)-3,4-dihydropyrimido[4,5-d]pyrimidin-2(1H)-one;Pyrimido[4,5-d]pyrimidin-2(1H)-one, 1-cyclohexyl-3-(2,6-dimethylphenyl)-3,4-dihydro-7-[[4-(4-methyl-1-piperazinyl)phenyl]amino]-
- CBNumber
- CB15821395
- Molecular Formula
- C31H39N7O
- Formula Weight
- 525.69
- MOL File
- 2172617-16-0.mol
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YKL-06-062 Property
- Boiling point:
- 706.2±70.0 °C(Predicted)
- Density
- 1.229±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble in DMSO
- form
- Solid
- pka
- 7.90±0.42(Predicted)
- color
- Light yellow to yellow
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N-Bromosuccinimide Price
ChemScene
- Product number
- CS-0103765
- Product name
- YKL-06-062
- Purity
- >98.0%
- Packaging
- 5mg
- Price
- $385
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0103765
- Product name
- YKL-06-062
- Purity
- >98.0%
- Packaging
- 10mg
- Price
- $655
- Updated
- 2021/12/16
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YKL-06-062 Chemical Properties,Usage,Production
Description
YKL-06-062 is a second-generation SIK inhibitor. YKL 06-062 induces significant pigmentation after 8 days of treatment (1×/day). YKL 06-062 did not require mechanical application (rubbing) to induce significant human epidermal darkening. YKL-06-062 induces not only synthesis of melanin but also melanosomal maturation, export, and localization features, even after import into keratinocytes.
Uses
YKL-06-062 is a second-generation salt-inducible kinase (SIK) inhibitor with an IC50 of 2.12 nM/1.40 nM/2.86 nM for SIK1, SIK2 and SIK3, respectively[1].
References
[1] Mujahid N, et al. A UV-Independent Topical Small-Molecule Approach for Melanin Production in Human Skin. Cell Rep. 2017 Jun 13;19(11):2177-2184. DOI:10.1016/j.celrep.2017.05.042
YKL-06-062 Preparation Products And Raw materials
Raw materials
Preparation Products
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