MMP-9-IN-1

Product Name: MMP-9-IN-1
CAS No.: 502887-71-0
Chemical Name: MMP-9-IN-1
Synonyms: OUN87710;MMP-9-IN-1;OUN87710,MMP-9-IN-1;MMP-9-IN-1, 10 mM in DMSO;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin
CBNumber: CB15821461
Molecular Formula: C16H17F2N3O3S
Formula Weight: 369.39
MOL File: 502887-71-0.mol

More

Less

MMP-9-IN-1 Property

Density: 1.37±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO: 125 mg/mL (338.40 mM)
pka: 7.80±0.50(Predicted)
form: Solid
color: White to off-white

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

More

Less

N-Bromosuccinimide Price

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 5mg
Price: $350
Updated: 2021/12/16

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 10mg
Price: $550
Updated: 2021/12/16

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 50mg
Price: $1650
Updated: 2021/12/16

ChemScene

Product number: CS-0110110
Product name: MMP-9-IN-1
Purity: 99.74%
Packaging: 100mg
Price: $2250
Updated: 2021/12/16

DC Chemicals

Product number: 012834
Product name: MMP-9-IN-1
Packaging: 001
Price: $750
Updated: 2021/12/16

More

Less

MMP-9-IN-1 Chemical Properties,Usage,Production

Definition

ChEBI: MMP-9-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor and an antineoplastic agent. It is an organofluorine compound, an aromatic compound, a pyrimidone, an organic sulfide and a secondary carboxamide.

Biological Activity

MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the heme (PEX) domain of MMP-9 with a Kd of 2.1 μM.

in vivo

MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.

Animal Model:	4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor
Dosage:	20 mg/kg
Administration:	Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks,
Result:	Resulted in a profound delay in tumor growth. Inhibited cancer cell metastasis.

target

Target	Value
MMP-9 (Cell-free assay)	2.1 μM(Kd)

MMP-9-IN-1 Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

MMP-9-IN-1 Suppliers

China 31 United States 5 Global 36

Sichuan Wei Keqi Biological Technology Co., Ltd.

Tel: 028-81700200 18116577057
Fax: 028-81705658
Email: 3003855609@qq.com
Country: China
ProdList: 7787
Advantage: 56

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4573
Advantage: 55

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5944
Advantage: 55

ShangHai Biochempartner Co.,Ltd

Tel: 17754423994 17754423994
Fax: QQ:2853530913
Email: 2853530910@QQ.com
Country: China
ProdList: 8011
Advantage: 62

Shanghai Chaolan Chemical Technology Center

Tel: 021-QQ：65489617 15618227136
Fax: 21-5161 9052
Email: Sales@ATKchemical.com
Country: China
ProdList: 7312
Advantage: 58

Taizhou Crene Biotechnology Co. Ltd.

Tel: +86-0576-88813233 +86-13396860566
Email: sales@pharm-intermediates.com
Country: China
ProdList: 1991
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32161
Advantage: 58

InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
Advantage: 58

Shanghai Dongyang Biotechnology Co., Ltd.

Tel: 0512-0512-13601744364 13601744364
Email: chemsharker@126.com
Country: China
ProdList: 928
Advantage: 58

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

502887-71-0, MMP-9-IN-1Related Search:

MMP-9-IN-1

OUN87710

Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-

OUN87710,MMP-9-IN-1

N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide

PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin

MMP-9-IN-1, 10 mM in DMSO

502887-71-0

API