MMP-9-IN-1
- Product Name
- MMP-9-IN-1
- CAS No.
- 502887-71-0
- Chemical Name
- MMP-9-IN-1
- Synonyms
- OUN87710;MMP-9-IN-1;OUN87710,MMP-9-IN-1;MMP-9-IN-1, 10 mM in DMSO;N-(4-(Difluoromethoxy)phenyl)-2-((6-oxo-4-propyl-1,6-dihydropyrimidin-2-yl)thio)acetamide;Acetamide, N-[4-(difluoromethoxy)phenyl]-2-[(1,6-dihydro-6-oxo-4-propyl-2-pyrimidinyl)thio]-;PEX,anti-metastatic,metastasis,MMP,Matrix metalloproteinases,tumor,MMP 9 IN 1,inhibit,MMP9IN1,MMP-9,Inhibitor,lung,cancer,hemopexin
- CBNumber
- CB15821461
- Molecular Formula
- C16H17F2N3O3S
- Formula Weight
- 369.39
- MOL File
- 502887-71-0.mol
MMP-9-IN-1 Property
- Density
- 1.37±0.1 g/cm3(Predicted)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- solubility
- DMSO: 125 mg/mL (338.40 mM)
- pka
- 7.80±0.50(Predicted)
- form
- Solid
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- CS-0110110
- Product name
- MMP-9-IN-1
- Purity
- 99.74%
- Packaging
- 5mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- CS-0110110
- Product name
- MMP-9-IN-1
- Purity
- 99.74%
- Packaging
- 10mg
- Price
- $550
- Updated
- 2021/12/16
- Product number
- CS-0110110
- Product name
- MMP-9-IN-1
- Purity
- 99.74%
- Packaging
- 50mg
- Price
- $1650
- Updated
- 2021/12/16
- Product number
- CS-0110110
- Product name
- MMP-9-IN-1
- Purity
- 99.74%
- Packaging
- 100mg
- Price
- $2250
- Updated
- 2021/12/16
- Product number
- 012834
- Product name
- MMP-9-IN-1
- Packaging
- 001
- Price
- $750
- Updated
- 2021/12/16
MMP-9-IN-1 Chemical Properties,Usage,Production
Definition
ChEBI: MMP-9-IN-1 is a secondary carboxamide resulting from the formal condensation of the carboxy group of [(4-oxo-6-propyl-1,4-dihydropyrimidin-2-yl)sulfanyl]acetic acid with the amino group of 4-(difluoromethoxy)aniline. It is a specific matrix metalloproteinase-9 (MMP-9) inhibitor. It has a role as an EC 3.4.24.35 (gelatinase B) inhibitor and an antineoplastic agent. It is an organofluorine compound, an aromatic compound, a pyrimidone, an organic sulfide and a secondary carboxamide.
Biological Activity
MMP-9-IN-1 (OUN87710) is a specific inhibitor of matrix metalloproteinase-9 (MMP-9). MMP-9-IN-1 selectively targets the heme (PEX) domain of MMP-9 with a Kd of 2.1 μM.
in vivo
MMP-9-IN-1 (compound 2; 20 mg/kg; intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks) results in a profound delay in tumor growth in NCR-Nu mice bearing MDA-MB-435/GFP tumor.
MMP-9-IN-1 inhibits cancer cell metastasis in vivo.
| Animal Model: | 4-5 week-old female NCR-Nu mice bearing MDA-MB-435/GFP tumor |
| Dosage: | 20 mg/kg |
| Administration: | Intraperitoneal and intratumoral injection alternately; 6 days/week; for 14 weeks, |
| Result: | Resulted in a profound delay in tumor growth. Inhibited cancer cell metastasis. |
target
| Target | Value |
| MMP-9 (Cell-free assay) | 2.1 μM(Kd) |
MMP-9-IN-1 Preparation Products And Raw materials
Raw materials
Preparation Products
MMP-9-IN-1 Suppliers
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