PK150

Product Name: PK150
CAS No.: 2165324-62-7
Chemical Name: PK150
Synonyms: PK150;PK150-developer;PK150, 10 mM in DMSO;1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)urea;Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,2-difluoro-1,3-benzodioxol-5-yl)-;Bacterial,MRSA,MSSA,Gram-positive,PK-150,antibacterial,PK 150,PK150,Inhibitor,VISA,inhibit
CBNumber: CB15832810
Molecular Formula: C15H8ClF5N2O3
Formula Weight: 394.68
MOL File: 2165324-62-7.mol

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PK150 Property

Boiling point:: 322.1±42.0 °C(Predicted)
Density: 1.63±0.1 g/cm3(Predicted)
storage temp.: -20°C
solubility: Soluble in DMSO (up to at least 25 mg/ml).
form: solid
pka: 12.44±0.40(Predicted)
color: White
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SBR00043
Product name: PK150
Purity: Sorafenib analog
Packaging: 10MG
Price: $99
Updated: 2023/06/20

Adipogen Life Sciences

Product number: AG-CR1-0162-M025
Product name: PK150(SorafenibAnalog)
Purity: ≥98%(HPLC)
Packaging: 25mg
Price: $120
Updated: 2021/12/16

ChemScene

Product number: CS-0112109
Product name: PK150
Purity: 99.37%
Packaging: 5mg
Price: $150
Updated: 2021/12/16

ChemScene

Product number: CS-0112109
Product name: PK150
Purity: 99.37%
Packaging: 10mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0112109
Product name: PK150
Purity: 99.37%
Packaging: 50mg
Price: $750
Updated: 2021/12/16

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PK150 Chemical Properties,Usage,Production

Description

PK150 (2165324-62-7) is a Sorafenib analog that displays significant antibacterial activity against several pathogenic strains (S.aureus?NCTC8325, MIC = 0.3 μM; vancomycin -resistant enterococci, MIC = 3 μM; and?M.tuberculosis?MIC = 2 μM). It was inactive against Gram-negative bacteria. It effectively reduced persister cells in ciprofloxacin-treated stationary?S.aureus?cultures and effectively eradicated staphylococcus biofilms. PK150 did not develop antibacterial resistance in an agar-plate-based assay. Its antibacterial properties were attributed to demethylmenaquinone methyltransferase (MenG) inhibition and signal peptidase IB (SpsB) activation. PK150 displayed?in vivo?efficacy in a murine bloodstream infection model against methicillin-sensitive?S. aureus?and a neutropenic mouse thigh model against methicillin-resistant?S. aureus?strain ATCC33591. Inactive against a panel of over 250 human kinases.

References

1) Le?et al.?(2019)?Repurposing human kinase inhibitors to create an antibiotic active against drug-resistant Staphylococcus aureus, persisters and biofilms; Nat. Chem.?12?145

PK150 Preparation Products And Raw materials

Raw materials

Preparation Products

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PK150 Suppliers

China 18 United States 2 Global 20

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9804
Advantage: 58

Tianjin Kailiqi Biotechnology Co., Ltd.

Tel: 15076683720
Fax: 022-23754520
Email: klq@cw-bio.com
Country: China
ProdList: 5960
Advantage: 55

DC Chemicals

Tel: 021-58447131 13564518121
Email: sales@dcchemicals.com
Country: China
ProdList: 9409
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11218
Advantage: 58

Bide Pharmatech Ltd.

Tel: 400-1647117 13681763483
Email: product02@bidepharm.com
Country: China
ProdList: 62075
Advantage: 58

InvivoChem

Tel: 13549236410
Email: sales@invivochem.cn
Country: China
ProdList: 6753
Advantage: 58

TargetMol Chemicals Inc.

Tel: 4008200310
Email: marketing@tsbiochem.com
Country: China
ProdList: 24644
Advantage: 58

Aikon International Limited

Tel: 18626450290
Email: yftan@aikonchem.com
Country: China
ProdList: 10715
Advantage: 58

Henan Alpha Chemical Co., Ltd.

Tel: 0371-55013243 15324716602
Email: 2853979810@qq.com
Country: China
ProdList: 10001
Advantage: 58

Nanjing Tengyi Biotechnology Co., Ltd

Tel: 025-58851786 17714337195
Email: sales@tybiochem.com
Country: China
ProdList: 6830
Advantage: 58

2165324-62-7, PK150Related Search:

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PK150

Urea, N-[4-chloro-3-(trifluoromethyl)phenyl]-N'-(2,2-difluoro-1,3-benzodioxol-5-yl)-

1-(4-Chloro-3-(trifluoromethyl)phenyl)-3-(2,2-difluorobenzo[d][1,3]dioxol-5-yl)urea

Bacterial,MRSA,MSSA,Gram-positive,PK-150,antibacterial,PK 150,PK150,Inhibitor,VISA,inhibit

PK150-developer

PK150, 10 mM in DMSO

2165324-62-7

C15H8ClF5N2O3