9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

Product Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
CAS No.: 1124329-14-1
Chemical Name: 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
Synonyms: CS-511;AZ 3146;AZ 3146; AZ-3146;AZ3146 >=98% (HPLC);AZ3146; AZ 3146; AZ-3146;AZ3146 Mps1 Inhibitor III AZ-3146;9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one;9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one
CBNumber: CB52518786
Molecular Formula: C24H32N6O3
Formula Weight: 452.55
MOL File: 1124329-14-1.mol

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Property

Boiling point:: 621.0±65.0 °C(Predicted)
Density: 1.279
storage temp.: Store at +4°C
solubility: Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
form: solid
pka: 8.29±0.10(Predicted)
color: Off-white
Stability:: Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 19991
Product name: AZ 3146
Purity: ≥98%
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Cayman Chemical

Product number: 19991
Product name: AZ 3146
Purity: ≥98%
Packaging: 10mg
Price: $178
Updated: 2024/03/01

Cayman Chemical

Product number: 19991
Product name: AZ 3146
Purity: ≥98%
Packaging: 25mg
Price: $414
Updated: 2024/03/01

Cayman Chemical

Product number: 19991
Product name: AZ 3146
Purity: ≥98%
Packaging: 50mg
Price: $547
Updated: 2024/03/01

Tocris

Product number: 3994
Product name: AZ3146
Purity: ≥99%(HPLC)
Packaging: 50
Price: $1040
Updated: 2021/12/16

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Chemical Properties,Usage,Production

Description

AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2

Uses

AZ 3146 is a protein kinase Mps1 inhibitor.

storage

Store at +4°C

References

1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Preparation Products And Raw materials

Raw materials

Preparation Products

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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Suppliers

China 88 India 1 The Netherlands 1 United Kingdom 1 United States 19 Global 110

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1124329-14-1, 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-oneRelated Search:

NOTUMib-1 Elafibranor(GFT505) Acalabrutinib NORFLUOXETINE HYDROCHLORIDE MK-1775 ABT-199 MPI-0479605 PF-4708671 3-Chloro-N-{(1S)-2-[(N,N-dimethylglycyl)amino]-1-[(4-{8-[(1S)-1-hydroxyethyl]imidazo[1,2-a]pyridin-2-yl}phenyl)methyl]ethyl}-4-[(1-methylethyl)oxy]benzamide Fedratinib

AZ 3146; AZ-3146

CS-511

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one

AZ 3146

9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one

9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one

9-Cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-8H-purin-8-one AZ3146

9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9

AZ3146; AZ 3146; AZ-3146

8H-Purin-8-one, 9-cyclopentyl-7,9-dihydro-2-[[2-methoxy-4-[(1-methyl-4-piperidinyl)oxy]phenyl]amino]-7-methyl-

AZ3146 >=98% (HPLC)

9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one

9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one USP/EP/BP

AZ3146 Mps1 Inhibitor III AZ-3146

1124329-14-1

Inhibitors