ChemicalBook > CAS DataBase List > 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
- Product Name
- 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
- CAS No.
- 1124329-14-1
- Chemical Name
- 9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one
- Synonyms
- CS-511;AZ 3146;AZ 3146; AZ-3146;AZ3146 >=98% (HPLC);AZ3146, 10 mM in DMSO;AZ3146; AZ 3146; AZ-3146;AZ3146 Mps1 Inhibitor III AZ-3146;9-Cyclopentyl-2-({2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]phenyl}amino)-7-methylpurin-8-one;9-Cyclopentyl-2-((2-methoxy-4-((1-methylpiperidin-4-yl)oxy)phenyl)amino)-7-methyl-7H-purin-8(9;9-cyclopentyl-2-(2-Methoxy-4-(1-Methylpiperidin-4-yloxy)phenylaMino)-7-Methyl-7H-purin-8(9H)-one
- CBNumber
- CB52518786
- Molecular Formula
- C24H32N6O3
- Formula Weight
- 452.55
- MOL File
- 1124329-14-1.mol
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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Property
- Boiling point:
- 621.0±65.0 °C(Predicted)
- Density
- 1.279
- storage temp.
- Store at +4°C
- solubility
- Soluble in DMSO (up to 10 mg/ml) or in Ethanol (up to at least 25 mg/ml)
- form
- solid
- pka
- 8.29±0.10(Predicted)
- color
- Off-white
- Stability:
- Stable for 1 year as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 1 month.
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N-Bromosuccinimide Price
Cayman Chemical
- Product number
- 19991
- Product name
- AZ 3146
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $106
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19991
- Product name
- AZ 3146
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $178
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19991
- Product name
- AZ 3146
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $414
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 19991
- Product name
- AZ 3146
- Purity
- ≥98%
- Packaging
- 50mg
- Price
- $547
- Updated
- 2024/03/01
Tocris
- Product number
- 3994
- Product name
- AZ3146
- Purity
- ≥99%(HPLC)
- Packaging
- 50
- Price
- $1040
- Updated
- 2021/12/16
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9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Chemical Properties,Usage,Production
Description
AZ3146 (1124329-14-1) is a potent (IC50?= 35 nM) and selective monopolar spindle 1 (Mps1/TTK) kinase inhibitor.1?Mps1 has an essential role in the spindle assembly checkpoint, an inhibitory network that restrains anaphase until all kinetochores are stably attached to spindle microtubules during mitosis. AZ3146 decreased hepatocellular carcinoma growth in vitro (SMMC-7721 and BEL-7404 cells).2
Uses
AZ 3146 is a protein kinase Mps1 inhibitor.
storage
Store at +4°C
References
1) Hewitt?et al. (2010)?Sustained Mps1 activity is required in mitosis to recruit O-Mad2 to the Mad1-C-Mad2 core complex; J. Cell Biol.?190?25 2) Liu?et al.?(2015)?TTK activates Akt and promotes proliferation and migration of hepatocellular carcinoma cells; Oncotarget?6?34309
9-Cyclopentyl-2-[[2-methoxy-4-[(1-methylpiperidin-4-yl)oxy]-phenyl]amino]-7-methyl-7,9-dihydro-8H-purin-8-one Preparation Products And Raw materials
Raw materials
Preparation Products
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