Tyrphostin AG1433
- Product Name
- Tyrphostin AG1433
- CAS No.
- 168835-90-3
- Chemical Name
- Tyrphostin AG1433
- Synonyms
- Tyrphostin A 1433;Tyrphostin AG1433, 10 mM in DMSO;1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-;cytotoxicity,PDGFRβ,Tyrphostin AG 1433,AG-1433,Tyrphostin AG1433,VEGFR,AG 1433,kinases,Vascular endothelial growth factor receptor,SU 1433,Tyrphostin AG-1433,Platelet-derived growth factor receptor,angiogenesis,tyrosine,inhibit,VEGFR-2,Inhibitor,ATM,PDGFR,SU-1433
- CBNumber
- CB15854618
- Molecular Formula
- C16H14N2O2
- Formula Weight
- 266.29
- MOL File
- 168835-90-3.mol
Tyrphostin AG1433 Property
- Melting point:
- 280-282 °C
- Boiling point:
- 490.9±45.0 °C(Predicted)
- Density
- 1.300±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 62.5 mg/mL (234.71 mM)
- pka
- 8.32±0.20(Predicted)
- form
- Solid
- color
- Light yellow to khaki
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P330Rinse mouth.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- CS-0077937
- Product name
- TyrphostinAG1433
- Purity
- 99.20%
- Packaging
- 5mg
- Price
- $150
- Updated
- 2021/12/16
- Product number
- CS-0077937
- Product name
- TyrphostinAG1433
- Purity
- 99.20%
- Packaging
- 10mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0077937
- Product name
- TyrphostinAG1433
- Purity
- 99.20%
- Packaging
- 50mg
- Price
- $650
- Updated
- 2021/12/16
- Product number
- CS-0077937
- Product name
- TyrphostinAG1433
- Purity
- 99.20%
- Packaging
- 100mg
- Price
- $1050
- Updated
- 2021/12/16
- Product number
- 012455
- Product name
- TyrphostinAG1433
- Packaging
- 003
- Price
- $1800
- Updated
- 2021/12/16
Tyrphostin AG1433 Chemical Properties,Usage,Production
Biological Activity
Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation.
in vivo
Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.
target
| Flk-1 < span> 9.3 μM (IC 50 ) | PDGFRβ 5 μM (IC 50 ) |
Tyrphostin AG1433 Preparation Products And Raw materials
Raw materials
Preparation Products
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