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Tyrphostin AG1433

Product Name
Tyrphostin AG1433
CAS No.
168835-90-3
Chemical Name
Tyrphostin AG1433
Synonyms
1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-;cytotoxicity,PDGFRβ,Tyrphostin AG 1433,AG-1433,Tyrphostin AG1433,VEGFR,AG 1433,kinases,Vascular endothelial growth factor receptor,SU 1433,Tyrphostin AG-1433,Platelet-derived growth factor receptor,angiogenesis,tyrosine,inhibit,VEGFR-2,Inhibitor,ATM,PDGFR,SU-1433
CBNumber
CB15854618
Molecular Formula
C16H14N2O2
Formula Weight
266.29
MOL File
168835-90-3.mol
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Tyrphostin AG1433 Property

Melting point:
280-282 °C
Boiling point:
490.9±45.0 °C(Predicted)
Density 
1.300±0.06 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 62.5 mg/mL (234.71 mM)
pka
8.32±0.20(Predicted)
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H332Harmful if inhaled

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P330Rinse mouth.

P363Wash contaminated clothing before reuse.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

ChemScene
Product number
CS-0077937
Product name
TyrphostinAG1433
Purity
99.20%
Packaging
5mg
Price
$150
Updated
2021/12/16
ChemScene
Product number
CS-0077937
Product name
TyrphostinAG1433
Purity
99.20%
Packaging
10mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0077937
Product name
TyrphostinAG1433
Purity
99.20%
Packaging
50mg
Price
$650
Updated
2021/12/16
ChemScene
Product number
CS-0077937
Product name
TyrphostinAG1433
Purity
99.20%
Packaging
100mg
Price
$1050
Updated
2021/12/16
DC Chemicals
Product number
012455
Product name
TyrphostinAG1433
Packaging
003
Price
$1800
Updated
2021/12/16
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Tyrphostin AG1433 Chemical Properties,Usage,Production

Biological Activity

Tyrphostin AG1433 (SU1433) is a tyrosine kinase inhibitor. It is also a selective PDGFRβ and VEGFR-2 (Flk-1/KDR) inhibitor with IC50 of 5.0 μM and 9.3 μM, respectively. It prevents blood vessel formation.

in vivo

Chorion allantoic membrane (CAM) assays are used to determine the effects of the Flk-i inhibitors on angiogenesis. Tyrphostin AG1433 (SU1433) is prepared in methylcellulose pellets and applies to the CAMs of 4-6-day- old chicken embryos. Tyrphostin AG1433 prevents the formation of new yessels under the pellets.

target

Flk-1

< span> 9.3 μM (IC 50 )

PDGFRβ

5 μM (IC 50 )

Tyrphostin AG1433 Preparation Products And Raw materials

Raw materials

Preparation Products

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Tyrphostin AG1433 Suppliers

Tianjin Kailiqi Biotechnology Co., Ltd.
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Shanghai Jieshikai Biotechnology Co. , Ltd.
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168835-90-3, Tyrphostin AG1433Related Search:


  • 1,2-Benzenediol, 4-(6,7-dimethyl-2-quinoxalinyl)-
  • cytotoxicity,PDGFRβ,Tyrphostin AG 1433,AG-1433,Tyrphostin AG1433,VEGFR,AG 1433,kinases,Vascular endothelial growth factor receptor,SU 1433,Tyrphostin AG-1433,Platelet-derived growth factor receptor,angiogenesis,tyrosine,inhibit,VEGFR-2,Inhibitor,ATM,PDGFR,SU-1433
  • 168835-90-3