ChemicalBook > CAS DataBase List > Dihydromyricetin

Dihydromyricetin

Product Name
Dihydromyricetin
CAS No.
27200-12-0
Chemical Name
Dihydromyricetin
Synonyms
ampeloptin;AMPELOPSIN;Two hydrogenMyricetin;vine tea extract dihydromyricetin;DihydroMyricetin, froM Myrica rubra;3,3’,4’,5,5’,7-hexahydroxy-flavanon;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3',4',5,5;,(2r-trans)-
CBNumber
CB1670507
Molecular Formula
C15H12O8
Formula Weight
320.25
MOL File
27200-12-0.mol
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Dihydromyricetin Property

storage temp. 
-20°C
solubility 
DMSO: ≥5mg/mL (warmed)
form 
powder
Boiling point:
780.7±60.0 °C(Predicted)
Density 
1.808±0.06 g/cm3(Predicted)
Melting point:
239-241 °C
pka
7.38±0.60(Predicted)
color 
white to beige
Stability:
Hygroscopic
InChI
InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
InChIKey
KJXSIXMJHKAJOD-LSDHHAIUSA-N
SMILES
[C@H]1(C2=CC(O)=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP
1.230 (est)
CAS DataBase Reference
27200-12-0
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Safety

Safety Statements 
24/25
WGK Germany 
3
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
42866
Product name
Dihydromyricetin
Purity
analytical standard
Packaging
10mg
Price
$176
Updated
2022/05/15
TCI Chemical
Product number
D5464
Product name
Dihydromyricetin
Purity
>97.0%(HPLC)
Packaging
200mg
Price
$186
Updated
2024/03/01
TCI Chemical
Product number
D5464
Product name
Dihydromyricetin
Purity
>97.0%(HPLC)
Packaging
1g
Price
$511
Updated
2024/03/01
Cayman Chemical
Product number
23549
Product name
Dihydromyricetin
Purity
≥98%
Packaging
5mg
Price
$81
Updated
2024/03/01
Cayman Chemical
Product number
23549
Product name
Dihydromyricetin
Purity
≥98%
Packaging
10mg
Price
$129
Updated
2024/03/01
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Dihydromyricetin Chemical Properties,Usage,Production

Description

Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound, which is found in large quantities in Asian plant species. One of them – Hovenia dulcis – is known for centuries in traditional Chinese medicine as a cure for alcohol poisoning and hangover (Liang et al. 2014). DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties.
Dihydromyricetin had beneficial effects on health such as antimicrobial, anti-inflammatory,antioxidative, anticancer, lipid and glucose metabolism-regulatory activities，and cell death-mediating without or with minimum adverse effects on normal cells. And most importantly, DHM has been shown to provide significant hepatoprotective effects. Its positive influence on alcohol-induced and other liver diseases was suggested in the study of acute liver failure (Liu et al. 2017).

Uses

Dihydromyricetin has been used to study its effect on adipogenesis and glucose uptake in differentiated 3T3-L1 pre-adipocytes. It has also been used to study its antitumor activity against liver cancer cells.

Definition

ChEBI: (+)-dihydromyricetin is an optically active form of dihydromyricetin having (2R,3R)-configuration. It has a role as a metabolite, an antioxidant and an antineoplastic agent. It is a secondary alpha-hydroxy ketone and a dihydromyricetin. It is an enantiomer of a (-)-dihydromyricetin.

benefits

Dihydromyricetin (DHM) relieves alcohol toxicity and prevents intoxication by limiting the absorption of alcohol in the gastrointestinal tract and promoting the metabolisation of alcohol in the liver. DHM is a promising compound for kidney protection, liver protection, and neurological protection when drinking alcohol.
DHM benefits can include things like:
relieve hangover
relieve anxiety
cardioprotective properties
protect the liver

Biochem/physiol Actions

Dihydromyricetin (Ampelopsin) is a flavanonol with antioxidant and anti-cancer activity, found to have anti-alcohol intoxication effects. Its anti-alcohol effects appear to be by its actions as a positive modulator of GABA-A receptors at the benzodiazepine site.

Side effects

Dihydromyricetin has been used in Asia for thousands of years as a hangover cure and anti-intoxication medicine and is considered safe for humans even in massive doses.
In a DHM toxicity study, researchers failed to find any side-effects while giving mice massive doses of up to 22g/kg body weight.
Acute toxicity tests showed that a single dose of oral SHE up to 22 g/kg did not result in any death or toxic side effects in mice during 14 days'observation.
Conversions from rat to human pharmacology can be estimated using the HED ratio of 16%, giving DHM a safe upper limit dosage of 15.68g for a 70kg person.

Dihydromyricetin Preparation Products And Raw materials

Raw materials

Preparation Products

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Dihydromyricetin Suppliers

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View Lastest Price from Dihydromyricetin manufacturers

Hebei Zhuanglai Chemical Trading Co.,Ltd
Product
Dihydromyricetin Powder 27200-12-0
Price
US $120.00/kg
Min. Order
1kg
Purity
99%
Supply Ability
20ton
Release date
2024-05-17
Changsha Staherb Natural Ingredients Co., Ltd.
Product
vine tea extract dihydromyricetin 27200-12-0
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
1%-98% HPLC
Supply Ability
1000kg
Release date
2022-11-15
Changsha Staherb Natural Ingredients Co., Ltd.
Product
Dihydromyricetin 27200-12-0
Price
US $80.00-2000.00/kg
Min. Order
1kg
Purity
1%-98% HPLC
Supply Ability
1000kg
Release date
2022-11-15

27200-12-0, DihydromyricetinRelated Search:

alpha-Dihydroartemisinin Myricetin Tetrahydropyran Centchroman 3'-HYDROXYFLAVANONE (+)-GALLOCATECHIN DIHYDROFISETIN 2,3-DIHYDROROBINETIN PINOBANKSIN (+/-)-Catechin hydrate Cianidanol Phloretin ERIODICTYOL Butin (+/-)-TAXIFOLIN DIHYDROKAEMPFEROL (+)-TAXIFOLIN ERIODICTYOL DIHYDROCHALCONE

  • 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on
  • 3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol
  • 3,3’,4’,5,5’,7-hexahydroxy-flavanon
  • DihydroMyricetin, froM Myrica rubra
  • Two hydrogenMyricetin
  • (2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one
  • Dihydromyricetin (+)-Dihydromyricetin
  • Ampelopsin (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
  • Ampelopsin(AMP)
  • Dihydromyricetin (DHM)
  • Dihydromyricetin, 98%, from Myrica rubra
  • 3,3',4',5,5
  • Nano Liposomal Dihydromyricetin
  • 3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one
  • Dihydromyricetin 27200-12-0
  • 4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-
  • ampelopsin(flavanol)
  • ampeloptin
  • DIHYDROMYRICETIN(RG)
  • 3,3’,4’,5,5’,7-hexahydroxyflavanone
  • (2R)-2,3-Dihydro-3β,5,7-trihydroxy-2α-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one
  • (2R)-2α-(3,4,5-Trihydroxyphenyl)-3β,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one
  • DihydroMyricetin(AMpeloptin)
  • DihydroMyricetin, AMpelopsin
  • (+)-Dihydromyricetin
  • (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one
  • AMPELOPSIN
  • (2r-trans)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benz
  • ,(2r-trans)-
  • aMpeloptin,(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroMan-4-one
  • Dihydromyricetin 25%-98%
  • Dihydromyricetin,HPLC≥98%
  • Dihydromyricetin Powder 27200-12-0 Dihydromyricetin
  • vine tea extract dihydromyricetin
  • DIHYDROMYRICETIN
  • Water-soluble DihydroMyricetin, Liposomal DihydroMyricetin
  • Vine Tea. Dihydromyricetin
  • Hovenia Dulcis Extract. Dihydromyricetin
  • dihydrromyricetin
  • Pea Protein 222400-29-5
  • Dihydrosalicylate
  • Dihydromyricetin Powder
  • DIHYDROMYRICETIN HCL
  • Dihydromyricetin-RM
  • 27200-12-0
  • C21H12O8
  • natural product
  • Inhibitors
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • chemical reagent
  • pharmaceutical intermediate
  • Flavanones
  • 27200-12-0