Dihydromyricetin

ChemicalBook > CAS DataBase List > Dihydromyricetin

Product Name: Dihydromyricetin
CAS No.: 27200-12-0
Chemical Name: Dihydromyricetin
Synonyms: ampeloptin;AMPELOPSIN;Two hydrogenMyricetin;vine tea extract dihydromyricetin;DihydroMyricetin, froM Myrica rubra;3,3’,4’,5,5’,7-hexahydroxy-flavanon;3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol;2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on;3,3',4',5,5;,(2r-trans)-
CBNumber: CB1670507
Molecular Formula: C15H12O8
Formula Weight: 320.25
MOL File: 27200-12-0.mol

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Dihydromyricetin Property

storage temp.: -20°C
solubility: DMSO: ≥5mg/mL (warmed)
form: powder
Boiling point:: 780.7±60.0 °C(Predicted)
Density: 1.808±0.06 g/cm3(Predicted)
Melting point:: 239-241 °C
pka: 7.38±0.60(Predicted)
color: white to beige
Stability:: Hygroscopic
InChI: InChI=1S/C15H12O8/c16-6-3-7(17)11-10(4-6)23-15(14(22)13(11)21)5-1-8(18)12(20)9(19)2-5/h1-4,14-20,22H/t14-,15+/m0/s1
InChIKey: KJXSIXMJHKAJOD-LSDHHAIUSA-N
SMILES: [C@H]1(C2=CC(O)=C(O)C(O)=C2)OC2=CC(O)=CC(O)=C2C(=O)[C@@H]1O
LogP: 1.230 (est)
CAS DataBase Reference: 27200-12-0

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Safety

Safety Statements: 24/25
WGK Germany: 3
HS Code: 29329990

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 42866
Product name: Dihydromyricetin
Purity: analytical standard
Packaging: 10mg
Price: $176
Updated: 2022/05/15

TCI Chemical

Product number: D5464
Product name: Dihydromyricetin
Purity: >97.0%(HPLC)
Packaging: 200mg
Price: $186
Updated: 2024/03/01

TCI Chemical

Product number: D5464
Product name: Dihydromyricetin
Purity: >97.0%(HPLC)
Packaging: 1g
Price: $511
Updated: 2024/03/01

Cayman Chemical

Product number: 23549
Product name: Dihydromyricetin
Purity: ≥98%
Packaging: 5mg
Price: $81
Updated: 2024/03/01

Cayman Chemical

Product number: 23549
Product name: Dihydromyricetin
Purity: ≥98%
Packaging: 10mg
Price: $129
Updated: 2024/03/01

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Dihydromyricetin Chemical Properties,Usage,Production

Description

Dihydromyricetin (DHM), also known as ampelopsin, is a natural flavonoid compound, which is found in large quantities in Asian plant species. One of them – Hovenia dulcis – is known for centuries in traditional Chinese medicine as a cure for alcohol poisoning and hangover (Liang et al. 2014). DHM is sold as a supplement and is commonly marketed as a treatment for hangovers due to its ability to reduce blood alcohol levels and projected hepatoprotective properties.
Dihydromyricetin had beneficial effects on health such as antimicrobial, anti-inflammatory,antioxidative, anticancer, lipid and glucose metabolism-regulatory activities，and cell death-mediating without or with minimum adverse effects on normal cells. And most importantly, DHM has been shown to provide significant hepatoprotective effects. Its positive influence on alcohol-induced and other liver diseases was suggested in the study of acute liver failure (Liu et al. 2017).

Uses

Dihydromyricetin has been used to study its effect on adipogenesis and glucose uptake in differentiated 3T3-L1 pre-adipocytes. It has also been used to study its antitumor activity against liver cancer cells.

Definition

ChEBI: (+)-dihydromyricetin is an optically active form of dihydromyricetin having (2R,3R)-configuration. It has a role as a metabolite, an antioxidant and an antineoplastic agent. It is a secondary alpha-hydroxy ketone and a dihydromyricetin. It is an enantiomer of a (-)-dihydromyricetin.

benefits

Dihydromyricetin (DHM) relieves alcohol toxicity and prevents intoxication by limiting the absorption of alcohol in the gastrointestinal tract and promoting the metabolisation of alcohol in the liver. DHM is a promising compound for kidney protection, liver protection, and neurological protection when drinking alcohol.
DHM benefits can include things like:
relieve hangover
relieve anxiety
cardioprotective properties
protect the liver

Biochem/physiol Actions

Dihydromyricetin (Ampelopsin) is a flavanonol with antioxidant and anti-cancer activity, found to have anti-alcohol intoxication effects. Its anti-alcohol effects appear to be by its actions as a positive modulator of GABA-A receptors at the benzodiazepine site.

Side effects

Dihydromyricetin has been used in Asia for thousands of years as a hangover cure and anti-intoxication medicine and is considered safe for humans even in massive doses.
In a DHM toxicity study, researchers failed to find any side-effects while giving mice massive doses of up to 22g/kg body weight.
Acute toxicity tests showed that a single dose of oral SHE up to 22 g/kg did not result in any death or toxic side effects in mice during 14 days'observation.
Conversions from rat to human pharmacology can be estimated using the HED ratio of 16%, giving DHM a safe upper limit dosage of 15.68g for a 70kg person.

Dihydromyricetin Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Dihydromyricetin manufacturers

Wuhan Haorong Biotechnology Co.,Ltd

Product: Dihydromyricetin 27200-12-0
Price: US $0.00-0.00/kg
Min. Order: 20kg
Purity: 99%
Supply Ability: 200000
Release date: 2023-08-15

Hebei Kingfiner Technology Development Co.Ltd

Product: Dihydromyricetin 27200-12-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 0.99
Supply Ability: 500000kg
Release date: 2024-05-07

Changsha Staherb Natural Ingredients Co., Ltd.

Product: vine tea extract dihydromyricetin 27200-12-0
Price: US $0.00-0.00/kg
Min. Order: 1kg
Purity: 1%-98% HPLC
Supply Ability: 1000kg
Release date: 2022-11-15

27200-12-0, DihydromyricetinRelated Search:

alpha-Dihydroartemisinin Myricetin Tetrahydropyran Centchroman 3'-HYDROXYFLAVANONE (+)-GALLOCATECHIN DIHYDROFISETIN 2,3-DIHYDROROBINETIN PINOBANKSIN (+/-)-Catechin hydrate Cianidanol Phloretin ERIODICTYOL Butin (+/-)-TAXIFOLIN DIHYDROKAEMPFEROL (+)-TAXIFOLIN ERIODICTYOL DIHYDROCHALCONE

2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benzopyran-4-on

3,3’,4’,5,5’,7-hexahydroxy-2,3-dihydroflavanonol

3,3’,4’,5,5’,7-hexahydroxy-flavanon

DihydroMyricetin, froM Myrica rubra

Two hydrogenMyricetin

(2R,3R)-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-2,3-dihydrochromen-4-one

Dihydromyricetin (+)-Dihydromyricetin

Ampelopsin (2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one

Ampelopsin(AMP)

Dihydromyricetin (DHM)

Dihydromyricetin, 98%, from Myrica rubra

3,3',4',5,5

Nano Liposomal Dihydromyricetin

3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-3,4-dihydro-2H-1-benzopyran-4-one

Dihydromyricetin 27200-12-0

4H-1-Benzopyran-4-one, 2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-, (2R,3R)-

ampelopsin(flavanol)

ampeloptin

DIHYDROMYRICETIN(RG)

3,3’,4’,5,5’,7-hexahydroxyflavanone

(2R)-2,3-Dihydro-3β,5,7-trihydroxy-2α-(3,4,5-trihydroxyphenyl)-4H-1-benzopyran-4-one

(2R)-2α-(3,4,5-Trihydroxyphenyl)-3β,5,7-trihydroxy-2,3-dihydro-4H-1-benzopyran-4-one

DihydroMyricetin(AMpeloptin)

DihydroMyricetin, AMpelopsin

(+)-Dihydromyricetin

(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroman-4-one

AMPELOPSIN

(2r-trans)-2,3-dihydro-3,5,7-trihydroxy-2-(3,4,5-trihydroxyphenyl)-4h-1-benz

,(2r-trans)-

aMpeloptin,(2R,3R)-3,5,7-Trihydroxy-2-(3,4,5-trihydroxyphenyl)chroMan-4-one

Dihydromyricetin 25%-98%

Dihydromyricetin,HPLC≥98%

Dihydromyricetin Powder 27200-12-0 Dihydromyricetin

vine tea extract dihydromyricetin

DIHYDROMYRICETIN

Water-soluble DihydroMyricetin, Liposomal DihydroMyricetin

Vine Tea. Dihydromyricetin

Hovenia Dulcis Extract. Dihydromyricetin

dihydrromyricetin

Pea Protein 222400-29-5

Dihydrosalicylate

27200-12-0

C21H12O8

natural product

Inhibitors

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract

chemical reagent

pharmaceutical intermediate

Flavanones

27200-12-0