DIHYDROFISETIN

Product Name: DIHYDROFISETIN
CAS No.: 20725-03-5
Chemical Name: DIHYDROFISETIN
Synonyms: FUSTIN;FUSTIN(SH);FUSTIN 97%;DIHYDROFISETIN;2,3-DIHYDROFISETH;2,3-DIHYDROFISETIN;5-Deoxydihydrouercetin;3',4',7-TRIHYDROXYFLAVANONOL;3,3',4',7-TETRAHYDROXYFLAVANONE;3,7,3',4'-TETRAHYDROXYFLAVANONE
CBNumber: CB0256494
Molecular Formula: C15H12O6
Formula Weight: 288.25
MOL File: 20725-03-5.mol

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DIHYDROFISETIN Property

Melting point:: 216-217°C
storage temp.: -20°C
solubility: Acetone: soluble,Chloroform: soluble,Dichloromethane: soluble,DMSO: soluble,Ethyl Acetate: soluble
form: A solid
Boiling point:: 644.2±55.0 °C(Predicted)
Density: 1.599±0.06 g/cm3(Predicted)
pka: 7.59±0.60(Predicted)
color: White to off-white
LogP: 0.870

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Safety

Risk Statements: 36/37/38
Safety Statements: 26-36

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC

Product number: T795753
Product name: 3,3'',4'',7-Tetrahydroxyflavanone
Packaging: 10mg
Price: $130
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT66081
Product name: 3,3',4',7-Tetrahydroxyflavanone
Packaging: 25mg
Price: $200
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT66081
Product name: 3,3',4',7-Tetrahydroxyflavanone
Packaging: 50mg
Price: $300
Updated: 2021/12/16

AK Scientific

Product number: W1554
Product name: Fustin
Packaging: 25mg
Price: $320
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FT66081
Product name: 3,3',4',7-Tetrahydroxyflavanone
Packaging: 100mg
Price: $400
Updated: 2021/12/16

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DIHYDROFISETIN Chemical Properties,Usage,Production

Uses

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) is a potent amyloid β (Aβ) inhibitor. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases the expression of acetylcholine (ACh) levels, choline acetyltransferase (ChAT) activity, and ChAT gene induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) decreases in acetyl cholinesterase (AChE) activity and AChE gene expression induced by Aβ (1-42). Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) increases muscarinic M1 receptor gene expression and muscarinic M1 receptor binding activity. Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) can be used for Alzheimer's disease research[1].

Definition

ChEBI: A dihydroflavonol that is the 2,3-dihydro derivative of fisetin.

in vivo

Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) attenuates Aβ (1-42)-induced impairments in conditioned fear learning and passive avoidance behavior^[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) alters Aβ (1-42)-induced changes in ACh level and AChE and ChAT activity and gene expression^[1].
Fustinis ((±)-Fustin; 3,7,3',4'-Tetrahydroxyflavanone) (50-100 mg/kg; p.o.; daily, for 11days; Aβ-treated C57BL/6 mice) increases Aβ (1-42)-induced reduction in M1 receptor mRNA and protein expression in Aβ-treated C57BL/6 mice. Fustin increases p-ERK and p-CREB expression in Aβ-treated C57BL/6 mice^[1].

Animal Model:	Aβ-treated C57BL/6 mice^[1]
Dosage:	50 and 100 mg/kg
Administration:	Oral administration;daily, for 11days
Result:	Decreased freezing response in Aβ-treated C57BL/6 mice.

Animal Model:	Aβ-treated C57BL/6 mice^[1]
Dosage:	50 and 100 mg/kg
Administration:	Oral administration;daily, for 11days
Result:	Increased the expression of Ach, ChAT gene and ChAT activity. Decreased the expression of AChE gene and AChE activity.

Animal Model:	Aβ-treated C57BL/6 mice^[1]
Dosage:	50 and 100 mg/kg
Administration:	Oral administration;daily, for 11days
Result:	Increased gene expression of M2- , M3- ,M4-, M5-, α4β, α7-receptor, p-ERK and p-CREB.

References

[1] Jin CH, et, al. Fustin flavonoid attenuates beta-amyloid (1-42)-induced learning impairment. J Neurosci Res. 2009 Dec;87(16):3658-70. DOI:10.1002/jnr.22159

DIHYDROFISETIN Preparation Products And Raw materials

Raw materials

Preparation Products

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DIHYDROFISETIN Suppliers

China 77 Germany 2 India 1 Japan 1 South Korea 1 United Kingdom 5 United States 11 USA 1 Global 99

Meryer (Shanghai) Chemical Technology Co., Ltd.

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3B Pharmachem (Wuhan) International Co.,Ltd.

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BioBioPha Co., Ltd.

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ALB Technology Limited

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View Lastest Price from DIHYDROFISETIN manufacturers

Career Henan Chemical Co

Product: DIHYDROFISETIN 20725-03-5
Price: US $29.00/KG
Min. Order: 10KG
Purity: 99%
Supply Ability: 10000kg
Release date: 2018-07-27

20725-03-5, DIHYDROFISETINRelated Search:

2-(3,4-Dihydroxyphenyl)-8-(2-O-beta-L-galactopyranosyl-beta-D-glucopyranosyl)-5,7-dihydroxy-4H-1-Benzopyran-4-one Hydroxyecdysone (4E,6E)-1,7-Diphenyl-4,6-heptadien-3-one Fisetin (3R)-Vestitol Taxifolin Aloin Silibinin Isosilybin Dihydromyricetin DIHYDROFISETIN Silicristin (+/-)-TAXIFOLIN (+)-TAXIFOLIN SILYBIN A/B ISOSILYBIN A AND B TAXIFOLIN 7-O-ALPHA-L RHAMNOSIDE AKOS NCG1-0054

DIHYDROFISETIN

3,3',4',7-TETRAHYDROXYFLAVANONE

3',4',7-TRIHYDROXYFLAVANONOL

2,3-DIHYDROFISETH

2,3-DIHYDROFISETIN

3,3,4,7-TETRAHYDROXYFLAVANONE 97%

3,7,3'',4''-TETRAHYDROXYFLAVANONE WITH HPLC

5-Deoxydihydrouercetin

rel-(2R*)-2α*-(3,4-Dihydroxyphenyl)-3β*,7-dihydroxy-2,3-dihydro-4H-1-benzopyran-4-one

rel-(2α*)-3β*,3',4',7-Tetrahydroxyflavanone

FUSTIN(SH)

trans-2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-4-benzopyrone

FUSTIN 97%

3,7,3',4'-TETRAHYDROXYFLAVANONE

FUSTIN

4H-1-Benzopyran-4-one, 2-(3,4-dihydroxyphenyl)-2,3-dihydro-3,7-dihydroxy-, (2R,3R)-rel-

3,7,3',4'-Tetrahydroxyflavanone (Fustin)

20725-03-5

Dihydro-Flavanols