ChemicalBook > CAS DataBase List > Isosilybin

Isosilybin

Product Name
Isosilybin
CAS No.
72581-71-6
Chemical Name
Isosilybin
Synonyms
Q-100795;Isosilybin;Isosilybinin;ISOSILIBININ;indissolubly;Isosilybin,ISB;ISOSILYBIN hplc;Isosilybin USP/EP/BP;Isosilybin (A+B) mixture;Isosilybin (Isosilybinin)
CBNumber
CB5359479
Molecular Formula
C25H22O10
Formula Weight
482.44
MOL File
72581-71-6.mol
More
Less

Isosilybin Property

Boiling point:
793.0±60.0 °C(Predicted)
Density 
1.527±0.06 g/cm3(Predicted)
pka
7.39±0.60(Predicted)
More
Less

Hazard and Precautionary Statements (GHS)

More
Less

N-Bromosuccinimide Price

Cayman Chemical
Product number
24913
Product name
Isosilybin
Purity
≥95%
Packaging
1mg
Price
$199
Updated
2021/12/16
Cayman Chemical
Product number
24913
Product name
Isosilybin
Purity
≥95%
Packaging
5mg
Price
$896
Updated
2021/12/16
Cayman Chemical
Product number
24913
Product name
Isosilybin
Purity
≥95%
Packaging
10mg
Price
$1692
Updated
2021/03/22
TRC
Product number
I901000
Product name
Isosilybin
Packaging
1mg
Price
$235
Updated
2021/12/16
Usbiological
Product number
300505
Product name
Isosilybin
Packaging
10mg
Price
$448
Updated
2021/12/16
More
Less

Isosilybin Chemical Properties,Usage,Production

Description

Isosilybin is a flavanolignan found in the extract of S. marianum fruits with antioxidant and anticancer activities. It inhibits lipid peroxidation in rat liver microsomes (IC50 = 32 μM) and reduces ADP/Fe3+-induced malondialdehyde (MDA) production and lactate dehydrogenase (LDH) release in rat hepatocytes. Isosilybin inhibits the production of reactive oxygen species (ROS), MDA and LDH release, and reduction in total antioxidant capacity induced by amyloid-β (25-35) (Aβ25-35) in HT-22 hippocampal cells. It also increases protein and mRNA expression of heme oxygenase-1 (HO-1), glutathione S-transferase (GST), and the aldo-keto reductases (AKCR) 1C1 and AKCR1C2 in HT-22 cells. In vivo, isosilybin (50 and 100 mg/kg) reduces tumor volume and increases tumor cell apoptosis in a DU145 prostate cancer mouse xenograft model. It also reduces expression of the tumor angiogenesis markers CD31, nestin, VEGF, VEGFR1, VEGFR2, phospho-Akt, and HIF-1α in tumor tissue without reducing blood vessel count in non-cancerous liver, lung, and kidney tissue in DU145 tumor-bearing mice.

Uses

Useful in the treatment of liver disease.

Uses

Isosilybin is useful in the treatment of liver disease

Definition

ChEBI: A flavonolignan isolated from Silybum marianum.

Isosilybin Preparation Products And Raw materials

Raw materials

Preparation Products

More
Less

Isosilybin Suppliers

J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
BOC Sciences
Email
info@bocsci.com
Country
United States
ProdList
21113
Advantage
65
ShangHai YuanYe Biotechnology Co., Ltd.
Tel
021-61312847-
Fax
021-55068248
Email
3008007399@qq.com
Country
China
ProdList
4995
Advantage
60
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
028-85911938-
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9750
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
028-82633397-
Fax
+86-28-82633165
Email
daisy@biopurify.cn
Country
China
ProdList
2040
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 QQ:1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
Cheng Du Micxy Chemical Co.,Ltd
Tel
028-85632863-
Fax
028-85632863
Email
sales@micxy.com;
Country
China
ProdList
13065
Advantage
58
More
Less

View Lastest Price from Isosilybin manufacturers

Zhuozhou Wenxi import and Export Co., Ltd
Product
Isosilybin 72581-71-6
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-06-27
Shanghai Standard Technology Co., Ltd.
Product
Isosilybin 72581-71-6
Price
US $0.00/mg
Min. Order
20mg
Purity
≥98%(HPLC)
Supply Ability
100 g
Release date
2020-08-12
Career Henan Chemical Co
Product
Isosilybin 72581-71-6
Price
US $1.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200kg
Release date
2019-12-31

72581-71-6, IsosilybinRelated Search:


  • ISOSILIBININ
  • ISOSILYBIN(PRIMARY STANDARD)
  • Isosilybinin
  • Isosilybin (Isosilybinin)
  • (2R,3R)-2-[2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • ISOSILYBIN hplc
  • Isosilybin (A+B) mixture
  • -(2,3-Dihydro-2-(4-hydroxy-3-Methoxyphenyl)-3-(hydroxyMethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • 2-(2,3-Dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl)-2,3-dihydro-3,5,7-trihydroxy-4H-1-benzopyran-4-one
  • Isosilybin
  • 4H-1-Benzopyran-4-one,2-[2,3-dihydro-2-(4-hydroxy-3-methoxyphenyl)-3-(hydroxymethyl)-1,4-benzodioxin-6-yl]-2,3-dihydro-3,5,7-trihydroxy-,(2R,3R)-
  • Q-100795
  • Isosilybin (Mixture of Diastereomers)
  • Isosilybin,ISB
  • Isosilybin USP/EP/BP
  • indissolubly
  • 72581-71-6
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Miscellaneous Natural Products
  • Intermediates & Fine Chemicals
  • Pharmaceuticals