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Isocorynoxeine

Product Name
Isocorynoxeine
CAS No.
51014-29-0
Chemical Name
Isocorynoxeine
Synonyms
Isocorynoxeine;Isocorynoxeine, BR;Isocorynoxeine USP/EP/BP;Isocorynoxeine, 10 mM in DMSO;Isocorynoxeine (7-Isocorynoxeine);(16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester;Methyl (E)-3-methoxy-2-((3S,6'R,7'S,8a'S)-2-oxo-6'-vinyl-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)acrylate;methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate;Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-;(alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester
CBNumber
CB41483206
Molecular Formula
C22H26N2O4
Formula Weight
382.46
MOL File
51014-29-0.mol
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Isocorynoxeine Property

Boiling point:
562.7±50.0 °C(Predicted)
Density 
1.25
solubility 
DMSO : 50 mg/mL (130.74 mM; Need ultrasonic)
form 
Powder
pka
13.54±0.60(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

TRC
Product number
I797200
Product name
7-Isocorynoxeine
Packaging
1mg
Price
$115
Updated
2021/12/16
TRC
Product number
I797200
Product name
7-Isocorynoxeine
Packaging
2.5mg
Price
$235
Updated
2021/12/16
Usbiological
Product number
300475
Product name
Isocorynoxeine
Packaging
10mg
Price
$433
Updated
2021/12/16
ApexBio Technology
Product number
N2468
Product name
Isocorynoxeine
Packaging
20mg
Price
$450
Updated
2021/12/16
Biorbyt Ltd
Product number
orb105685
Product name
Isocorynoxeine
Purity
>98%,Standard References Grade
Packaging
20mg
Price
$569.5
Updated
2021/12/16
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Isocorynoxeine Chemical Properties,Usage,Production

Description

The leaves of Mitragyna rotundlfolia grown in Burma have recently been found to contain this alkaloid. This is the first reported occurrence of the base in nature. The structure has been established from spectroscopic investigations.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Uncaria rhynchophylla.

Uses

7-Isocorynoxeine is a bioactive oxindole alkaloid in the Uncaria species. Displays wide array of beneficial cardiovascular and cardiocerebral vascular system effects.

in vivo

The effects of Rhynchophylline, Corynoxeine, and Isocorynoxeine, isorhynchophylline-related alkaloids present are tested in Uncaria species, on 5-MeO-DMT-induced head-twitch behaviour in reserpinized mice. Neither Rhynchophylline [H=1.369, P=0.504] nor Corynoxeine [H=0.242, P=0.886] affects the behaviour, while Isocorynoxeine significantly attenuates it at 30 mg/kg (i.p.) [H=7.582, P<0.01][1].

target

5-HT2A receptor | NO

IC 50

5-HT2A Receptor: 72.4 μM (IC50)

References

Houghton, Shellard, Planta Med., 26, 104 (1974)

Isocorynoxeine Preparation Products And Raw materials

Raw materials

Preparation Products

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Isocorynoxeine Suppliers

China 158 United States 15 Global 173
Sichuan Kulinan Technology Co., Ltd
Tel
400-1166-196 18981987031
Fax
028-84555506 800101999
Email
cdhxsj@163.com
Country
China
ProdList
11705
Advantage
57
Shenzhen Sungening Bio-Tech Co., Ltd
Tel
+86-0755-89668383
Fax
+86-0755-89594066/4038
Email
sales@sungening.com
Country
China
ProdList
1319
Advantage
65
BioBioPha Co., Ltd.
Tel
0871-65217109 13211707573;
Fax
0871-65215563
Email
y.liu@mail.biobiopha.com
Country
China
ProdList
5653
Advantage
65
Chengdu Ai Keda Chemical Technology Co., Ltd.
Tel
4008-755-333 18080918076
Fax
028-86757656
Email
800078821@qq.com
Country
China
ProdList
9718
Advantage
55
Chengdu Biopurify Phytochemicals Ltd.
Tel
+86-028-82633397 18982077548
Fax
+86-28-82633165
Email
cwb1@biopurify.cn
Country
China
ProdList
2376
Advantage
60
Chengdu Climax Biotech Co., Ltd.
Tel
028-83311324 1278112614
Fax
028-83311324
Email
climaxbiotech@gmail.com
Country
China
ProdList
925
Advantage
58
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12335
Advantage
58
Haoyuan Chemexpress Co., Ltd.
Tel
021-58950125
Fax
(86) 21-58955996
Email
info@chemexpress.com
Country
China
ProdList
7552
Advantage
61
Shanghai Ruji Biology Technology Co., Ltd.
Tel
+86-21-65211385-8001 36031160
Fax
+86-21-65211385-8004
Email
sales@shruji.com
Country
China
ProdList
3224
Advantage
55
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
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View Lastest Price from Isocorynoxeine manufacturers

Shanghai Standard Technology Co., Ltd.
Product
Isocorynoxeine 51014-29-0
Price
US $0.00/mg
Min. Order
5mg
Purity
≥98%(HPLC)
Supply Ability
10 g
Release date
2020-01-02
Career Henan Chemical Co
Product
Isocorynoxeine 51014-29-0
Price
US $1.00/kg
Min. Order
1 mg
Purity
99%
Supply Ability
100KG
Release date
2018-12-25

51014-29-0, IsocorynoxeineRelated Search:

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  • Isocorynoxeine
  • (16E,20α)-16,17,18,19-Tetradehydro-17-methoxy-2-oxocorynoxan-16-carboxylic acid methyl ester
  • (alphaE,1'S,6'R,7'S,8'aS)-6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-alpha-(methoxymethylene)-2-oxospiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid methyl ester
  • Isocorynoxeine, BR
  • Isocorynoxeine (7-Isocorynoxeine)
  • Spiro[3H-indole-3,1'(5'H)-indolizine]-7'-acetic acid, 6'-ethenyl-1,2,2',3',6',7',8',8'a-octahydro-α-(methoxymethylene)-2-oxo-, methyl ester, (αE,1'S,6'R,7'S,8'aS)-
  • Isocorynoxeine USP/EP/BP
  • methyl (E)-2-[(3S,6'R,7'S,8'aS)-6'-ethenyl-2-oxospiro[1H-indole-3,1'-3,5,6,7,8,8a-hexahydro-2H-indolizine]-7'-yl]-3-methoxyprop-2-enoate
  • Methyl (E)-3-methoxy-2-((3S,6'R,7'S,8a'S)-2-oxo-6'-vinyl-2',3',6',7',8',8a'-hexahydro-5'H-spiro[indoline-3,1'-indolizin]-7'-yl)acrylate
  • Isocorynoxeine, 10 mM in DMSO
  • 51014-29-0
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract