Description References
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Isorhamnetin

Description References
Product Name
Isorhamnetin
CAS No.
480-19-3
Chemical Name
Isorhamnetin
Synonyms
c.i.75680;ISOHAMNETIN;sorhamnetin;Isorhanetin;ISORHAMNETIN;isorhamnetol;3-METHYLQUERCETIN;ISORHAMNETIN hplc;3’-methoxyquercetin;Isorhamnetin (15 mg)
CBNumber
CB0472359
Molecular Formula
C16H12O7
Formula Weight
316.26
MOL File
480-19-3.mol
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Isorhamnetin Property

Melting point:
307°C
Boiling point:
599.4±50.0 °C(Predicted)
Density 
1.634±0.06 g/cm3(Predicted)
storage temp. 
2-8°C
pka
6.31±0.40(Predicted)
form 
neat
BRN 
44723
InChIKey
IZQSVPBOUDKVDZ-UHFFFAOYSA-N
CAS DataBase Reference
480-19-3(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi,Xn
Risk Statements 
36/37/38-40
Safety Statements 
22-36-26-36/37
WGK Germany 
3
RTECS 
LK9275450
HS Code 
29329990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H351Suspected of causing cancer

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

P281Use personal protective equipment as required.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
17794
Product name
Isorhamnetin
Purity
≥95.0% (HPLC)
Packaging
5mg
Price
$146
Updated
2021/12/16
Sigma-Aldrich
Product number
PHL89314
Product name
Isorhamnetin
Purity
phyproof? Reference Substance
Packaging
20 mg
Price
$410
Updated
2021/12/16
Sigma-Aldrich
Product number
04290585
Product name
Isorhamnetin
Purity
primary pharmaceutical reference standard
Packaging
10mg
Price
$626
Updated
2021/12/16
Sigma-Aldrich
Product number
38907
Product name
Isorhamnetin
Purity
analytical standard
Packaging
10mg
Price
$434
Updated
2021/03/22
Sigma-Aldrich
Product number
1351800
Product name
Isorhamnetin
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
30mg
Price
$356
Updated
2021/03/22
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Isorhamnetin Chemical Properties,Usage,Production

Description

Isorhamnetin is a flavonoid, which occurs naturally in plants and it is also a metabolite of quercetin.
Isorhamnetin has anti-inflammatory effect as it can reduce the formation of large amounts of nitric oxide by the inhibition the activation of nuclear factor-κB (NF-κB), which is a significant transcription factor for inducible nitric oxide synthase.  Isorhamnetin is also reported to have effect in inducing the expression of neurofilaments, and it potentiated the NGF-induced neurite outgrowth and neurofilament expression, which could be a new direction in searching potential candidates as new drugs or food supplements for neurodegenerative diseases.

References

[1] Mari Hämäläinen, Riina Nieminen, Pia Vuorela, Marina Heinonen and Eeva Moilanen, Anti-Inflammatory Effects of Flavonoids: Genistein, Kaempferol, Quercetin, and Daidzein Inhibit STAT-1 and NF-κB Activations, Whereas Flavone, Isorhamnetin, Naringenin, and Pelargonidin Inhibit only NF-κB Activation along with Their Inhibitory Effect on iNOS Expression and NO Production in Activated Macrophages, Mediators of Inflammation, 2007, vol. 2007, Article ID 45673
[2] Sherry L. Xu, Roy C. Y. Choi, Kevin Y. Zhu, Ka-Wing Leung, Ava J. Y. Guo, Dan Bi, Hong Xu, David T. W. Lau, Tina T. X. Dong and Karl W. K. Tsim, Isorhamnetin, A Flavonol Aglycone from Ginkgo biloba L., Induces Neuronal Differentiation of Cultured PC12 Cells: Potentiating the Effect of Nerve Growth Factor, Evidence-Based Complementary and Alternative Medicine, 2012, vol. 2012, Article ID 278273

Chemical Properties

Beige to lighet yellow powder

Uses

A metabolite of the flavanoid Quercetin (Q509500) with antioxidant properties. It helps to protect H9c2 cardiomyoblasts against H2O2-induced oxidative stress via the modulation of PI3K/Akt and ERK1/2 signaling pathways.

Uses

Isorhamnetin is a natural flavonol aglycone that is the 3-methyl metabolite of quercetin . It has antioxidant activity and inhibits xanthine oxidase (IC50 = 0.40 μM). Isorhamnetin also competitively inhibits the human multidrug and toxic compounds extrusion transporter 1 (Ki = 0.32 μM), which has an important role in the excretion of xenobiotics at the kidney and liver. It has also been reported to potentiate the neurological actions of nerve growth factor, diminish the cardiotoxic impact of doxorubicin, and have beneficial anti-cancer effects.

Uses

Reference Standard in the analysis of herbal medicinal products

Definition

ChEBI: A monomethoxyflavone that is quercetin in which the hydroxy group at position 3' is replaced by a methoxy group.

General Description

Produced and qualified by HWI pharma services GmbH.
Exact content by quantitative NMR can be found on the certificate.

Biochem/physiol Actions

Isorhamnetin inhibits adipogenesis by interfering with differentiation of adipose stem cells, by a mechanism involving stabilization of β-catenin and up-regulating the Wnt signaling pathway.

Isorhamnetin Preparation Products And Raw materials

Raw materials

Preparation Products

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Isorhamnetin Suppliers

Chengdu Biopurify Phytochemicals Ltd.
Tel
028-82633397-
Fax
+86-28-82633165
Email
daisy@biopurify.cn
Country
China
ProdList
2040
Advantage
60
Chengdu Peter-like Biotechnology Co., Ltd.
Tel
028-81700200-
Email
2850505130@qq.com
Country
China
ProdList
2715
Advantage
58
MedBio?Pharmaceutical Technology Inc
Tel
021-69568360-
Email
order@med-bio.cn
Country
China
ProdList
8143
Advantage
58
Guizhou Dida Technology Co., Ltd
Tel
0851-84752296- ;
Fax
0851-84752205
Email
646585516@qq.com;1813593468@qq.com
Country
China
ProdList
2777
Advantage
58
Shanghai Boyle Chemical Co., Ltd.
Fax
86-21-57758967
Email
sales@boylechem.com
Country
China
ProdList
2926
Advantage
55
J & K SCIENTIFIC LTD.
Tel
010-82848833- ;010-82848833-
Fax
86-10-82849933
Email
jkinfo@jkchemical.com;market6@jkchemical.com
Country
China
ProdList
96815
Advantage
76
3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Chembest Research Laboratories Limited
Tel
021-20908456-
Fax
021-58180499
Email
sales@BioChemBest.com
Country
China
ProdList
5947
Advantage
61
Chemsky (shanghai) International Co.,Ltd
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
15424
Advantage
60
China DongFan Chemical Co.,LTD
Tel
86-0571-85151182
Fax
86-0571-85151182
Email
sales@dongfan-chem.com
Country
China
ProdList
5702
Advantage
66
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View Lastest Price from Isorhamnetin manufacturers

ZhenYiBio Technology Inc
Product
Isorhamnetin 480-19-3
Price
US $1100.00-1000.00/KG
Min. Order
1KG
Purity
24%
Supply Ability
800KGs
Release date
2022-01-02
NanJing Spring & Autumn Biological Engineering CO., LTD.
Product
Isorhamnetin 480-19-3 480-19-3
Price
US $20.00/mg
Min. Order
20mg
Purity
≥98%
Supply Ability
1000.00 kgs
Release date
2019-07-16
Zhuozhou Wenxi import and Export Co., Ltd
Product
Isorhamnetin 480-19-3
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-08-11

480-19-3, IsorhamnetinRelated Search:


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  • 3'-Methoxy-3,4',5,7-tetrahydroxyflavone 3,5,7-Trihydroxy-2-(4-hydroxy-3-metoxyphenyl)benzopyran-4-on 3,5,7-Trihydroxy-2-(4-hydroxy-3-methoxyphenyl)-4H-1-benzopyran-4-one
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  • 480-19-3
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  • Natural Dyes
  • Biochemicals and Reagents
  • BioChemical
  • Penta-substituted Flavones
  • Flavanols
  • Aromatics
  • Heterocycles
  • Intermediates & Fine Chemicals
  • Metabolites & Impurities
  • Pharmaceuticals
  • chemical reagent
  • pharmaceutical intermediate
  • phytochemical
  • reference standards from Chinese medicinal herbs (TCM).
  • standardized herbal extract
  • Inhibitors