Isoacteoside

Product Name: Isoacteoside
CAS No.: 61303-13-7
Chemical Name: Isoacteoside
Synonyms: Isoacteosid;Isokusaginin;ISOACTEOSIDE;ISOVERBASCOSIDE;Isoacteoside, >=98%;Isoacteoside，HPLC≥98%;Isoacteoside, 10 mM in DMSO;Isoacteoside (Isoverbascoside);3,4-Dihydroxyphenethyl 3-O-α-L-rhamnopyranosyl-6-O-(3,4-dihydroxycinnamoyl)-β-D-glucopyranoside;[(2R,3R,4S,5R,6R)-5-(3,4-Dihydroxyphenyl)-6-ethoxy-Chemicalbook3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3
CBNumber: CB8450300
Molecular Formula: C29H36O15
Formula Weight: 624.59
MOL File: 61303-13-7.mol

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Isoacteoside Property

Melting point:: 220～230℃
Boiling point:: 942.9±65.0 °C(Predicted)
Density: 1.60±0.1 g/cm3(Predicted)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
solubility: DMSO : ≥ 48 mg/mL (76.85 mM)
form: Powder
pka: 9.32±0.10(Predicted)
color: White to yellow
biological source: plant
InChIKey: FNMHEHXNBNCPCI-RRYJURSWNA-N

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Safety

HS Code: 29389090

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: PHL89232
Product name: Isoverbascoside
Purity: phyproof? Reference Substance
Packaging: 10MG
Price: $341
Updated: 2025/07/31

Cayman Chemical

Product number: 29216
Product name: Isoverbascoside
Packaging: 25mg
Price: $684
Updated: 2024/03/01

Cayman Chemical

Product number: 29216
Product name: Isoverbascoside
Packaging: 50mg
Price: $1139
Updated: 2024/03/01

Cayman Chemical

Product number: 29216
Product name: Isoverbascoside
Packaging: 5mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 29216
Product name: Isoverbascoside
Packaging: 10mg
Price: $290
Updated: 2024/03/01

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Isoacteoside Chemical Properties,Usage,Production

Description

Isoverbascoside is a phenylethanoid glycoside that has been found in C. trichotomum and has diverse biological activities. It scavenges 2,2-diphenyl-1-picrylhydrazyl (DPPH; ) radicals in a cell-free assay and inhibits hydrogen peroxide-induced lipid peroxidation in V79-4 cells when used at a concentration of 10 μg/ml. Isoverbascoside (7.5-30 μM) induces apoptosis and production of reactive oxygen species (ROS) in, and reduces viability of, OVCAR-3 cells. It inhibits tumor growth in an OVCAR-3 mouse xenograft model when administered at a dose of 30 mg/kg. Isoverbascoside (2.5 and 5 mg/kg) decreases brain amyloid deposition and increases exploratory behavior in rats when infused into the cerebral ventricles with amyloid-β (1-42) (Aβ42; ). It also decreases xylene-induced ear edema in mice and increases survival in a mouse model of LPS-induced endotoxic shock.

Chemical Properties

White crystalline powder, soluble in organic solvents such as methanol, ethanol, and DMSO, derived from Cistanche deserticola and Rehmannia glutinosa.

Uses

Isoacteoside is a possible food antioxidant.

Definition

ChEBI: Isoacteoside is a hydroxycinnamic acid.

in vivo

Isoacteoside (25-100 mg/kg, ip, single dose) exhibits anti-inflammatory efficacy in mouse xylene-induced ear edema models, LPS (HY-D1056)-induced endotoxin shock models, and LPS (HY-D1056)-induced acute kidney injury (AKI) models^[2].
Isoacteoside (30 mg/kg, ip, three times a week for 5 weeks) exhibits antitumor efficacy in mouse OVCAR-3 xenograft models^[3].
Isoacteoside (2.5-5 mg/kg, icv for 15 days) exhibits neuroprotective effect against Aβ 1-42-induced neurotoxicity and cognitive impairment in SD rats models^[5].

Animal Model:	Acute kidney injury (AKI) model^[2]
Dosage:	25-100 mg/kg
Administration:	ip, single dose
Result:	Ameliorated LPS induced acute kidney injury.

Animal Model:	Mouse OVCAR-3 xenograft model^[3]
Dosage:	30 mg/kg
Administration:	ip, three times a week for 5 weeks
Result:	Reduced the tumor weight and volume.

Animal Model:	Aβ 1-42 induced neurotoxicity in Sprague-Dawley rats models^[5]
Dosage:	2.5-5 mg/kg
Administration:	icv for 15 days
Result:	Increased the exploratory behavior, shortened the escape latency.

References

[1] SUNGWOOK CHAE. Antioxidant activity of isoacteoside from Clerodendron trichotomum.[J]. Journal of Toxicology and Environmental Health-Part A-Current Issues, 2005, 68 5: 389-400. DOI: 10.1080/15287390590900750
[2] XILI YANG. Suppression of in vitro and in vivo human ovarian cancer growth by isoacteoside is mediated via sub-G1 cell cycle arrest, ROS generation, and modulation of AKT/PI3K/m-TOR signalling pathway.[J]. Journal of Buon, 2019, 24 1: 285-290.
[3] YOUNG-JI SHIAO. Acteoside and Isoacteoside Protect Amyloid β Peptide Induced Cytotoxicity, Cognitive Deficit and Neurochemical Disturbances In Vitro and In Vivo.[J]. International Journal of Molecular Sciences, 2017, 18 4. DOI: 10.3390/ijms18040895
[4] HONGWEI GAO. Isoacteoside, a dihydroxyphenylethyl glycoside, exhibits anti-inflammatory effects through blocking toll-like receptor 4 dimerization[J]. British Journal of Pharmacology, 2017, 174 17: 2880-2896. DOI: 10.1111/bph.13912

Isoacteoside Preparation Products And Raw materials

Raw materials

Preparation Products

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Isoacteoside Suppliers

China 228 France 1 Germany 2 India 2 United Kingdom 3 United States 17 Global 253

Wuhan ChemFaces Biochemical Co., Ltd.

Tel: 18607101326 15172504745
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Hubei Danding Pharmaceutical Technology Co., Ltd

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Country: China
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Chembest Research Laboratories Limited

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Country: China
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Adamas Reagent, Ltd.

Tel: 400-6009262 16621234537
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Email: chenyj@titansci.com
Country: China
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Sichuan Kulinan Technology Co., Ltd

Tel: 400-1166-196 18981987031
Fax: 028-84555506 800101999
Email: cdhxsj@163.com
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Shenzhen Sungening Bio-Tech Co., Ltd

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Dalian Meilun Biotech Co., Ltd.

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BioBioPha Co., Ltd.

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Chengdu Ai Keda Chemical Technology Co., Ltd.

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Fax: 028-86757656
Email: 800078821@qq.com
Country: China
ProdList: 9718
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View Lastest Price from Isoacteoside manufacturers

Shanghai Standard Technology Co., Ltd.

Product: Isoacteoside 61303-13-7
Price: US $0.00/mg
Min. Order: 5mg
Purity: ≥98%(HPLC)
Supply Ability: 10 g
Release date: 2019-09-19

Career Henan Chemical Co

Product: Isoacteoside 61303-13-7
Price: US $1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: Customized
Release date: 2019-05-25

61303-13-7, IsoacteosideRelated Search:

ISOVITEXIN Isosilybin isomangiferin Isocorynoxeine Isorhamnetin FORSYTHOSIDE A ISOVITEXIN Diosgenin Rhamnosylvitexin No No 4-β-D-Glucopyranosyloxybenzeneethanol ISOQUERCETIN(P) Nicergoline Verbascoside Cabergoline Isoimperatorin isoMogroside V

Isokusaginin

Isoacteoside, >=98%

β-D-Glucopyranoside, 2-(3,4-dihydroxyphenyl)ethyl 3-O-(6-deoxy-α-L-mannopyranosyl)-, 6-[(2E)-3-(3,4-dihydroxyphenyl)-2-propenoate]

ISOVERBASCOSIDE

ISOACTEOSIDE

Isoacteosid

[(2R,3R,4S,5R,6R)-5-(3,4-Dihydroxyphenyl)-6-ethoxy-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

2-(3,4-Dihydroxyphenyl)ethyl 3-O-(α-L-rhamnopyranosyl)-6-O-[(E)-3-(3,4-dihydroxyphenyl)-1-oxo-2-propenyl]-β-D-glucopyranoside

2-(3,4-Dihydroxyphenyl)ethyl 3-O-(α-L-rhamnopyranosyl)-6-O-[(E)-3-(3,4-dihydroxyphenyl)acryloyl]-β-D-glucopyranoside

2-(3,4-Dihydroxyphenyl)ethyl 3-O-α-L-rhamnopyranosyl-6-O-(3,4-dihydroxycinnamoyl)-β-D-glucopyranoside

3,4-Dihydroxyphenethyl 3-O-α-L-rhamnopyranosyl-6-O-(3,4-dihydroxycinnamoyl)-β-D-glucopyranoside

Isoacteoside，HPLC≥98%

Isoacteoside (Isoverbascoside)

[(2R,3R,4S,5R,6R)-6-[2-(3,4-dihydroxyphenyl)ethoxy]-3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyloxan-2-yl]oxyoxan-2-yl]methyl (E)-3-(3,4-dihydroxyphenyl)prop-2-enoate

((2R,3R,4S,5R,6R)-6-(3,4-Dihydroxyphenethoxy)-3,5-dihydroxy-4-(((2S,3R,4R,5R,6S)-3,4,5-trihydroxy-6-methyltetrahydro-2H-pyran-2-yl)oxy)tetrahydro-2H-pyran-2-yl)methyl (E)-3-(3,4-dihydroxyphenyl)acrylate

[(2R,3R,4S,5R,6R)-5-(3,4-Dihydroxyphenyl)-6-ethoxy-Chemicalbook3,5-dihydroxy-4-[(2S,3R,4R,5R,6S)-3

Isoacteoside, 10 mM in DMSO

61303-13-7

chemical reagent

pharmaceutical intermediate

phytochemical

reference standards from Chinese medicinal herbs (TCM).

standardized herbal extract